Type of reaction | Signs and symptoms | Time of Occurrence |
Allergic Reaction | Mild rash, urticarial, flushing, pruritus | 2-3 hours from start of transfusion |
Febrile Non-hemolytic | Increase in temperature ≥ 38OC or ≥ 1OC from pre-transfusion value, chills, malaise, rigors, nausea, vomiting | During transfusion |
Transfusion Associated Circulatory Overload (TACO) | Productive cough with frothy sputum, cyanosis, tachycardia, hypertension, dyspnea | Within hours of transfusion |
Acute hemolytic transfusion reaction (AHTR) | Chills, temperature to ≥ 39 OC, fever, hemoglobinuria, hypotension, renal failure, pain at site of infusion | Within first few minutes |
Anaphylactic | Respiratory distress, erythema, urticarial, bronchospasm, dyspnea, tachycardia, nausea, vomiting | Within 2-3 hours of start of transfusion |
Transfusion related acute lung injury (TRALI) | Hypoxemia, chills, fever, bilateral pulmonary edema, tachycardia, hypotension | Within 2 hours during transfusion sometimes 6 hours post transfusion |
Bacterial contamination | Shock, fever, DIC, nausea, vomiting, chills, rigors etc. Yersinia enterocolitica: common cause of post transfusion bacterial sepsis | Within hours of transfusion |
