Hematology Question Bank -

0 votes, 0 avg

GOOD LUCK

WELL DONE

Created by

quizshell

Hematology Question Bank

1 / 209

Category: Hematology

1. Which of the following is a lipid storage disorder caused by deficiency in glucocerebrosidase

A. Niemann-Pick disease

B. Gaucher disease

C. Alder normally

D. Chronic granulomatous disease (CGD)

2 / 209

Category: Hematology

2. The presence of the chromosomal abnormality t(15;17) with disseminated intravascular coagulation (DIC) is diagnostic of?

A. Acute myeloblastic leukemia without maturation (FAB type Ml)

B. Acute myeloblastic leukemia with maturation (FAB type M2)

C. Acute promyelocytic leukemia (FAB type M3)

D. Acute myelomonocytic leukemia (FAB type M4)

3 / 209

Category: Hematology

3. Which of the following stain is used to visualize iron granules in RBCs ?

A. Wright’s stain

B. Supravital stain

C. New methylene Blue

D. Prussian blue

4 / 209

Category: Hematology

4. Howell-Jolly bodies are composed of

A. Vitamin K

B. RNA

C. Iron granules

D. DNA

5 / 209

Category: Hematology

5. Burkitt lymphoma is associated with which of the following virus?

A. Polio Virus

B. Rotavirus

C. Coxcakie Virus

D. Epstein Barr Virus

6 / 209

Category: Hematology

6. Which type of anemia is associated with hypersegmented neutrophils?

A. Sideroblastic anemia

B. Megaloblastic anemia

C. Microcytic anemia

D. Thalassemia

7 / 209

Category: Hematology

7. Defective nuclear maturation commonly results in the production of red cells that are ?

A. Normocytic

B. Hypochromic

C. Macrocytic

D. Microcytic

8 / 209

Category: Hematology

8. World Health Organization (WHO) defines acute leukemia as?

A. >20% bone marrow blasts.

B. >30% bone marrow blasts.

C. >70% bone marrow blasts.

D. >50% bone marrow blasts.

9 / 209

Category: Hematology

9. Pancytopenia is seen in which type of anemia?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Aplastic anemia

D. Anemia of chronic inflammation

10 / 209

Category: Hematology

10. Which disorder occurs when glutamic acid is replaced by valine at position 6 on both beta chains.?

A. Hgb E

B. Hgb SC

C. Sickle Cell Disease (Hgb SS)

D. Hgb C

11 / 209

Category: Hematology

11. Which stain is useful in the diagnosis of erythroleukemia (FAB M6) and acute lymphoblastic leukemia?

A. Myeloperoxidase (MPO)

B. Periodic acid-Schiff (PAS)

C. Nonspecific esterase stains

D. Sudan Black

12 / 209

Category: Hematology

12. Which type of anemia will cause iron overload?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

13 / 209

Category: Hematology

13. Which of the following inclusions is only visible with supravital stain?

A. Dohle bodies

B. Pappenheimer bodies

C. Basophilic stippling

D. Heinz bodies

14 / 209

Category: Hematology

14. This rod is associated with acute promyelocytic leukemia(AML). Identify the cell?

A. Howell Jolly Bodies

B. Auer rods

C. Plasma cell

D. Reactive Lymphocytes

15 / 209

Category: Hematology

15. Identify the cell

A. Microcytic normochromic red blood cells

B. Microcytic hypochromic red blood cells

C. Macrocytic red blood cells

D. Normochromic red blood cells

16 / 209

Category: Hematology

16. Basophilia is associated with?

A. Type I hypersensitivity reactions

B. Leukemoid reaction (NLR)

C. Chronic myelogenous leukemia

D. Type I hypersensitivity reactions and chronic myelogenous leukemia

17 / 209

Category: Hematology

17. What is this cell?

A. Dacrocytes

B. Reticulocyte

C. Target cells

D. Elliptocytes

18 / 209

Category: Hematology

18. Hgb D Disease is caused by substitution of glutamic acid with.

A. Lysine

B. Valine

C. Leucine

D. Glycine

19 / 209

Category: Hematology

19. Which of the following stains are used to differentiate blasts of acute myelogenous leukemias (AMLs) from acute lymphoblastic leukemia (ALLs)?

A. Myeloperoxidase (MPO) and Sudan black B

B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS)

C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains

20 / 209

Category: Hematology

20. Neutrophils with 5 or more lobes are called ?

A. Multisegmented neutrophils

B. Hypersegmented neutrophils

C. Hyposegmented neutrophils

D. Monosegmented neutrophils

21 / 209

Category: Hematology

21. What is this cell?

A. Dacrocytes

B. Reticulocyte

C. Codocytes

D. Elliptocytes

22 / 209

Category: Hematology

22. Which of the following is associated with a “shift to the right” in the oxygen dissociation curve of hemoglobin ?

A. Decreased oxygen release

B. Increased pH, high 2,3-bisphosphoglycerate and increased body temperature

C. Decreased pH, high 2, 3-bisphosphoglycerate and elevated temperature

D. Decreased carbon release

23 / 209

Category: Hematology

23. What term describes a mature red blood cell that contains iron granules ?

A. Basophillic stippling

B. Siderocyte

C. Howell Jolly

D. Ringed sideroblast

24 / 209

Category: Hematology

24. Hemoglobinopathies are inherited disorders caused by

A. Amino acid substitutions

B. Block in NADPH

C. Abnormal Hemoglobin structure

D. Peptide mutation

25 / 209

Category: Hematology

25. What is the primary site for pre-B cell differentiation ?

A. Liver

B. Spleen

C. Thymus

D. Bone marrow

26 / 209

Category: Hematology

26. What is the MCHC?


Hemoglobin	11.1 g/dL
RBC	3.65 x 10^12/L
Hematocrit	32.5%

A. 32.2g/dL

B. 24.2g/dL

C. 34.2g/dL

D. 36.2g/dL

27 / 209

Category: Hematology

27. Basophilia is associated with ?

A. Type I hypersensitivity reactions

B. Leukemoid reaction (NLR)

C. Type I hypersensitivity reactions and chronic myelogenous leukemia

D. Chronic myelogenous leukemia

28 / 209

Category: Hematology

28. Di Guglielmo syndrome is also classified as?

A. Acute megakaryocytic leukemia (AMegL; FAB M7)

B. Acute erythroleukemia; FAB M6

C. Acute myelomonocytic leukemia ;AMML; FAB M4

D. Acute promyelocytic leukemia (APL); FAB M3

29 / 209

Category: Hematology

29. Which macrocytic anemia affects the Central Nervous System?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Folate deficiency

D. Vitamin B12 deficiency

30 / 209

Category: Hematology

30. Which of the following test is used to measure bone marrow erythropoiesis?

A. Hams Sugar test

B. Erythrocyte Sedimentation Rate

C. Reticulocyte count

D. Cell count

31 / 209

Category: Hematology

31. What is the MCV?


Hemoglobin	11.1 g/dL
RBC	3.65 x 10^12/L
Hematocrit	32.5%

A. 84fL

B. 79fL

C. 89fL

D. 92fL

32 / 209

Category: Hematology

32. A block in the protoporphyrin pathway resulting in defective hemoglobin synthesis is characteristic of which type of anemia?

A. Thalassemia

B. Porphyrias

C. Iron-deficiency anemia

D. Megaloblastic anemia

33 / 209

Category: Hematology

33. What is the genetic translocation in chronic myelogenous leukemia (CML)?

A. t(15;17)

B. t(9;22)

C. t(8;14); with a rearrangement of the MYC oncogene

D. t(11;17)

34 / 209

Category: Hematology

34. Impaired DNA metabolism is characteristic of which type of anemia?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

35 / 209

Category: Hematology

35. What does the term “poikilocytosis” mean?

A. Variations in size

B. Variations in shape

C. Variation of central palor

D. Variations in color

36 / 209

Category: Hematology

36. What is the primary site of hematopoiesis in the third month of gestation?

A. Spleen

B. Marrow of long bones

C. Liver

D. Yolk sac

37 / 209

Category: Hematology

37. A sudden loss of blood from traumatic injuries is..

A. Chronic blood loss

B. Reticulocytosis

C. Acute blood loss

38 / 209

Category: Hematology

38. Which of the following is the most commonly used routine stain for blood smear ?

A. Prussian blue

B. Supravital stain

C. Wright’s stain

D. New methylene Blue

39 / 209

Category: Hematology

39. What is the MCHC?


Hemoglobin	14.1 g/dL
RBC	4.12 x 10^12/L
Hematocrit	41.3%

A. 34.2g/dL

B. 34.1g/dL

C. 32.2g/dL

D. 27.2g/dL

40 / 209

Category: Hematology

40. Chronic myeloproliferative disorders terminate in?

A. Acute leukemia

B. Chronic leukemia

41 / 209

Category: Hematology

41. The most common cause of aplastic anemia is?

A. Idiopathic

B. Diamond-Blackfan anemia

C. Fanconi anemia

D. Sideroblastic anemia

42 / 209

Category: Hematology

42. What is this cell?

A. Hgb SS Crystals

B. Hgb SC Crystals

C. Hgb C Crystals

D. Hgb E Crystals

43 / 209

Category: Hematology

43. Which test is used to differentiate chronic myelogenous leukemia (CML) from a neutrophilic leukemoid reaction (NLR)?

A. Periodic acid-Schiff (PAS)

B. Nonspecific esterase stains

C. Sudan Black

D. Leukocyte alkaline phosphatase (LAP)

44 / 209

Category: Hematology

44. Hemoglobin A2 consists of ?

A. Two alpha- and two beta-globin chains

B. Two alpha- and four beta-globin chains

C. Two alpha- and two delta-globin chains

D. Four alpha- and two beta-globin chains

45 / 209

Category: Hematology

45. What is this cell?

A. Basophilic stipplings

B. Reticulocyte

C. Washed red blood cells

D. Artifact

46 / 209

Category: Hematology

46. Decrease in absolute number of neutrophils is called ?

A. Eosinophilia

B. Leukopenia

C. Neutropenia

D. Leukocytosis

47 / 209

Category: Hematology

47. An aggressive form of cutaneous T-cell lymphoma is?

A. Sezary syndrome

B. Mycosis fungoides

C. Reed-Sternberg syndrome

D. Chronic myelogenous leukemia (CML)

48 / 209

Category: Hematology

48. Which erythrocyte metabolic pathway generates 2,3-bisphosphoglycerate ?

A. Embden-Meyerhof

B. Hexose monophosphate

C. Rapoport-Luebering

D. Methemoglobin reductase

49 / 209

Category: Hematology

49. Adult hemoglobin consists of ?

A. Hgb F contains two alpha- and four beta-globin chains

B. Hgb A contains four alpha- and two beta-globin chains

C. Hgb A contains two alpha- and two beta-globin chains

D. Hgb F contains three alpha- and four beta-globin chains

50 / 209

Category: Hematology

50. What is this cell?

A. Macrophages

B. Monocytes

C. Plasma cell

D. Reactive Lymphocytes

51 / 209

Category: Hematology

51. What are the stages of granulocyte development ?

A. Myeloblast, Promyelocyte, Myelocyte, Metamyelocyte, band neutrophils

B. Myeloblast, Myelocyte, Promyelocyte, Metamyelocyte, band neutrophils

C. Myeloblast, Myelocyte, Metamyelocyte, Promyelocyte, band neutrophils

D. Myeloblast, Myelocyte, Metamyelocyte, band neutrophils

52 / 209

Category: Hematology

52. Which of the following anemia is associated with dwarfism and mental retardation?

A. Diamond-Blackfan anemia

B. Fanconi anemia

C. Sideroblastic anemia

D. Aplasia

53 / 209

Category: Hematology

53. Hemoglobin F consists of ?

A. Two alpha- and two beta-globin chains

B. Two alpha- and two gamma-globin chains

C. Two alpha- and two delta-globin chains

D. Four alpha- and two beta-globin chains

54 / 209

Category: Hematology

54. What is the MCV?


Hemoglobin	14.1 g/dL
RBC	4.12 x 10^12/L
Hematocrit	41.3%

A. 104fL

B. 79fL

C. 100.2fL

D. 99fL

55 / 209

Category: Hematology

55. What is the MCH?


Hemoglobin	11.1 g/dL
RBC	3.65 x 10^12/L
Hematocrit	32.5%

A. 31pg

B. 33 pg

C. 30.9pg

D. 30.4pg

56 / 209

Category: Hematology

56. What is this cell multi-lobed cells called?

A. Lymphocytes

B. Segmented Neutrophils

C. Monocytes

D. Eosinophils

57 / 209

Category: Hematology

57. In Waldenstrom macroglobulinemia which immunoglobin is increasingly produced?

A. IgM

B. IgG

C. IgA

D. IgS

58 / 209

Category: Hematology

58. What substance has a greater affinity for hemoglobin than oxygen ?

A. Carbon

B. Carbon dioxide

C. Carbonmonoxide

D. Oxide

59 / 209

Category: Hematology

59. What is the structure of the hemoglobin molecule ?

A. Two heme groups, two globin chains

B. Four heme groups, two globin chains

C. Four heme groups, four globin chains

D. Two heme groups, four globin chains

60 / 209

Category: Hematology

60. Which type of anemia would you see ringed sideroblasts?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

61 / 209

Category: Hematology

61. What does the term “anisocytosis” mean?

A. Variations in size

B. Variations in shape

C. Variation of central palor

D. Variations in color

62 / 209

Category: Hematology

62. What is the first type of blood cell produced by the developing embryo?

A. Thrombocyte

B. Granulocyte

C. Lymphocytes

D. Erythrocytes

63 / 209

Category: Hematology

63. What is a true increase in the number of lymphocytes called?

A. Absolute lymphopenia

B. Absolute lymphocytosis

C. Relative lymphocytosis

D. Absolute polycythemia

64 / 209

Category: Hematology

64. Which lymphoma has Reed-Sternberg cells?

A. Hodgkin lymphoma

B. Non-Hodgkin lymphoma

C. Acute lymphocytic leukemia (CLL)

D. Chronic myelogenous leukemia (CML)

65 / 209

Category: Hematology

65. Which classification for hematopoietic malignancy is the accepted standard for diagnosis?

A. French-American-British (FAB)

B. World Health Organization (WHO)

C. Cancer Association Method

66 / 209

Category: Hematology

66. What is an excessive accumulation of iron in body tissues called?

A. Hematoma

B. Heme toxicity

C. Hematopenia

D. Hemochromatosis

67 / 209

Category: Hematology

67. Which of the following test is used to measure bone marrow erythropoiesis?

A. Hams Sugar test

B. Reticulocyte count

C. Erythrocyte Sedimentation Rate

D. Cell count

68 / 209

Category: Hematology

68. The majority of iron found in an adult is a constituent of

A. Haptoglobin

B. Myoglobin

C. Hemoglobin

D. Propyria

69 / 209

Category: Hematology

69. What is an increase in the percentage of lymphocytes called ?

A. Absolute lymphopenia

B. Relative lymphocytosis

C. Absolute lymphocytosis

D. Absolute polycythemia

70 / 209

Category: Hematology

70. What is the primary site of hematopoiesis in the first month of gestation?

A. Spleen

B. Marrow of long bones

C. Liver

D. Yolk sac

71 / 209

Category: Hematology

71. What is the process of blood cell formation called?

A. Hemochromatosis

B. Apotosis

C. Hematopoiesis

D. Mitosis

72 / 209

Category: Hematology

72. Which of the following disorders is associated with left shift, toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score ?

A. Basophilic stipplings

B. Chronic myelogenous leukemia

C. Neutrophilic leukemoid reaction (NLR)

D. Acute myelogenous leukemia

73 / 209

Category: Hematology

73. Which stain is used for reticulocyte count ?

A. Wright’s stain

B. Supravital stain

C. New methylene Blue

D. Prussian blue

74 / 209

Category: Hematology

74. What is the oxidation state of iron in Hemoglobin ?

A. Oxide state

B. Ferrous state

C. Peroxide state

D. Ferric state

75 / 209

Category: Hematology

75. What red cell morphologic abnormality have unevenly pointed projections and associated with abetalipoproteinemia

A. Spherocytes

B. Echinocytes

C. Dacrocytes

D. Acanthocytes

76 / 209

Category: Hematology

76. Which gene mutation is implicated in polycythemia?

A. JAK2 oncogene

B. t(8;11)

C. BCR/ABL oncogene

D. t(11;17)

77 / 209

Category: Hematology

77. Which of the following is diagnostic of Multiple myeloma?

A. "M"-spike in the gamma-globulin region in serum electrophoresis

B. Bence Jones proteins in the urine

C. Excessive production IgM (macroglobulin)

D. production of excessive IgG (macroglobulin)

E. A ,B and D

78 / 209

Category: Hematology

78. Which stain is used for reticulocyte count?

A. Prussian blue

B. Wright’s stain

C. Supravital stain

D. New methylene Blue

79 / 209

Category: Hematology

79. What is the expected result of a solubility test for patients with Hgb SS disease?

A. Negative

B. Positive

80 / 209

Category: Hematology

80. What is this cell?

A. Dacrocytes

B. Reticulocyte

C. Sickle Cells

D. Elliptocytes

81 / 209

Category: Hematology

81. Which of the following red blood cell morphology abnormalities is associated hemoglobinopathies?

A. Ovalocytes

B. Target cells

C. Echinocytes

D. Acanthocytes

82 / 209

Category: Hematology

82. Which of the following disorder is associated with left shift with toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score?

A. Basophilic stipplings

B. Neutrophilic leukemoid reaction (NLR)

C. Chronic myelogenous leukemia

D. Acute myelogenous leukemia

83 / 209

Category: Hematology

83. Senescent RBCs are phagocytized by macrophages in the liver or spleen and removed through

A. Extravascular hemolysis

B. Intravascular hemolysis

C. Necrosis

D. Cell degeneration

84 / 209

Category: Hematology

84. Which of the following protein stimulates red blood cell production?

A. Erythropoietin

B. Transferrin

C. Hemopexin

D. Prealbumin

85 / 209

Category: Hematology

85. Which chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

A. t(15;17)

B. t(8;11)

C. t(8;14)

D. t(11;17)

86 / 209

Category: Hematology

86. Which gene mutation is associated with chronic myelogenous leukemia?

A. JAK2 oncogene

B. t(8;11)

C. t(8;14)

D. BCR/ABL oncogene

87 / 209

Category: Hematology

87. Which hemoglobin forms are incapable of oxygen transport ?

A. Deoxyhemoglobin and carboxyhemoglobin

B. Methemoglobin and deoxyhemoglobin

C. Oxyhemoglobin and deoxyhemoglobin

D. Carboxyhemoglobin and methemoglobin

88 / 209

Category: Hematology

88. Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

A. Reed-Sternberg cells

B. Mycosis fungoides

C. Sezary syndrome

D. Smudge cells

89 / 209

Category: Hematology

89. Pappenheimer bodies are composed of ?

A. Vitamin K

B. RNA

C. Iron granules

D. DNA

90 / 209

Category: Hematology

90. Impaired DNA metabolism is characteristic of which type of anemia ?

A. Thalassemia

B. Sideroblastic anemia

C. Megaloblastic anemia

D. Iron-deficiency anemia

91 / 209

Category: Hematology

91. Which of the following stain is used to visualize iron granules in RBCs?

A. Prussian blue

B. Wright’s stain

C. Supravital stain

D. New methylene Blue

92 / 209

Category: Hematology

92. What red cell morphologic abnormality has evenly spaced round projections and is associated with pyruvate kinase deficiency

A. Spherocytes

B. Echinocytes

C. Dacrocytes

D. Acanthocytes

93 / 209

Category: Hematology

93. Which malignant disorder is associated with left shift with myelocytes the predominate cell?

A. Acute myelogeneous leukemia

B. Chronic myelogenous leukemia

C. Acute promyelocytic leukemia (APL); FAB M3

D. Acute megakaryocytic leukemia (AMegL; FAB M7)

94 / 209

Category: Hematology

94. Thalassemias are the result of a?

A. Structural defect in the globin portion of hemoglobin

B. Quantitative defect in globin-chain synthesis

C. Qualitative defect in globin-chain structure

D. Qualitative defect in heme structure

95 / 209

Category: Hematology

95. Which of the following conditions is most commonly associated with pica?

A. Anemia of chronic inflammation

B. Alpha thalassemia

C. Iron deficiency

D. Lead poisoning

96 / 209

Category: Hematology

96. French-American-British (FAB) defines acute leukemia as?

A. >20% bone marrow blasts.

B. >30% bone marrow blasts.

C. >70% bone marrow blasts.

D. >50% bone marrow blasts.

97 / 209

Category: Hematology

97. What does Wright’s stain consist of ?

A. Methylene blue and cresyl green

B. Methylene blue and neutral red

C. Methylene blue and eosin

D. Methylene blue and Giemsa stain

98 / 209

Category: Hematology

98. An increased number of immature cell types in the peripheral blood is

A. Cell apoptosis

B. Cell degeneration

C. Right shift

D. Left shift

99 / 209

Category: Hematology

99. Diphyllobothrium latum is associated with the development of?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Lead poisoning

D. Vitamin B12 deficiency

100 / 209

Category: Hematology

100. Which protein regulates iron homeostasis ?

A. Hemosiderin

B. Transferrin

C. Hepcidin

D. Hemopexin

101 / 209

Category: Hematology

101. Microcytic, hypochromic red cells are most often associated with impaired

A. DNA synthesis

B. Hemoglobin synthesis

C. RNA metabolism

D. Enzyme metabolism

102 / 209

Category: Hematology

102. Which of the following factors will result in an immediate increase in oxygen delivery to the tissues ?

A. decreased body temperature

B. low 2,3-bisphosphoglycerate (2,3-BPG) level

C. Decreased pH

D. Decreased carbon release

103 / 209

Category: Hematology

103. What is the pH of blood ?

A. 7.35-7.45

B. 7.25-7.45

C. 7.30-7.45

D. 7.32-7.49

104 / 209

Category: Hematology

104. Which of the following is the major transport protein of iron ?

A. Transferrin

B. Ferritin

C. Hemosiderin

D. Haptoglobin

105 / 209

Category: Hematology

105. Which of the following red blood cell precursors is the last stage to undergo mitosis?

A. Band neutrophils

B. Promyelocyte

C. Myelocyte

D. Segmented neutrophils

106 / 209

Category: Hematology

106. Which of the following is the most commonly used routine stain for blood smear?

A. Prussian blue

B. Wright’s stain

C. Supravital stain

D. New methylene Blue

107 / 209

Category: Hematology

107. Which term describes a decrease in all blood cell lines?

A. Pancytopenia

B. Cellopenia

C. Reticulocytosis

D. Nucleopenia

108 / 209

Category: Hematology

108. What is the major storage form of iron?

A. Transferrin

B. Hemosiderin

C. Ferritin

D. Hemachromatin

109 / 209

Category: Hematology

109. Which cell type is predominant in acute lymphoblastic leukemia?

A. lymphoblasts

B. myeloblasts

C. granulocytes

110 / 209

Category: Hematology

110. Decreased haptoglobin is indicative of

A. Extravascular hemolysis

B. Intravascular hemolysis

C. Intramedullary hematopoiesis

D. Intermedullary hematopoiesis

111 / 209

Category: Hematology

111. Which of the following differentiates non-megaloblastic macrocytic anemias from megaloblastic anemias?

A. Oval erythrocytes in non-megaloblastic macrocytic

B. Round erythrocytes in megaloblastic anemias

C. Hypersegmented neutrophil in non-megaloblastic macrocytic

D. Round erythrocytes in non-megaloblastic macrocytic

112 / 209

Category: Hematology

112. Which hemoglobin migrates with Hgb S and Hgb G on alkaline hemoglobin electrophoresis?

A. Hgb F

B. Hgb C

C. Hgb D

D. Hgb SC

113 / 209

Category: Hematology

113. A cutaneous lymphoma that causes skin itching and ulcerative tumor are called?

A. Mycosis fungoides

B. Reed-Sternberg syndrome

C. Waldenstrom macroglobulinemia

114 / 209

Category: Hematology

114. What are the three stages of hematopoiesis?

A. Meroblastic phase, hepatic phase, and medullary phase

B. Mesoblastic phase, primitive phase, and medullary phase

C. Primitive phase, definitive phase and hepatic phase

D. Mesoblastic phase, hepatic phase, and medullary phase

CD13, CD33 positive (myeloid) and CD14 positive (monocytes)

115 / 209

Category: Hematology

115. Which of the following cell markers is positive in acute myelomonocytic leukemia (AMML; FAB M4)?

A. CD13, CD15, and CD33

B. CD13, CD33 positive and CD14 positive

C. CD45 and CD71

116 / 209

Category: Hematology

116. What is an increase in the percentage of lymphocytes called?

A. Absolute lymphopenia

B. Absolute lymphocytosis

C. Relative lymphocytosis

D. Absolute polycythemia

117 / 209

Category: Hematology

117. Impaired release of storage iron due to increased hepcidin levels will result in ?

A. Thalassemia

B. Sideroblastic anemia

C. Anemia of Chronic Inflammation

D. Iron-deficiency anemia

118 / 209

Category: Hematology

118. Defective hemoglobin synthesis due to a block in the protoporphyrin pathway will result in which type of anemia?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

119 / 209

Category: Hematology

119. Which of the following is a true red cell aplasia?

A. Diamond-Blackfan anemia

B. Fanconi anemia

C. Sideroblastic anemia

D. Aplasia

120 / 209

Category: Hematology

120. What is the primary site of hematopoiesis in the fifth month of gestation?

A. Spleen

B. Marrow of long bones

C. Liver

D. Yolk sac

121 / 209

Category: Hematology

121. Which abnormal red blood cell is seen in abetalipoproteinemia?

A. Spherocytes

B. Acanthocytes

C. Echinocytes

D. Codocytes

122 / 209

Category: Hematology

122. Which of the following is a lipid storage disorder caused by deficiency in sphingomyelinase, associated with foamy bone marrow appearance ?

A. Niemann-Pick disease

B. Gaucher disease

C. Alder normally

D. Chronic granulomatous disease (CGD)

123 / 209

Category: Hematology

123. Impaired DNA metabolism is characteristic of which type of anemia?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Lead poisoning

D. Vitamin B12 deficiency

124 / 209

Category: Hematology

124. What is this cell?

A. Dacrocytes

B. Schistocytes

C. Echinocytes

D. Acanthocytes

125 / 209

Category: Hematology

125. Which of the following acquired hemolytic disorder causes intravascular hemolysis, presents with thrombocytopenia and schistocytes in peripheral blood smear?

A. Microangiopathic hemolytic anemias (MAHAs)

B. Paroxysmal nocturnal hemoglobinuria (PNH)

C. Hemolytic uremic syndrome (HUS)

D. Thrombotic thrombocytopenic purpura (TTP)

E. All of the above

126 / 209

Category: Hematology

126. In normocytic/normochromic anemia reticulocyte is

A. Increased

B. Decreased

C. Normal

127 / 209

Category: Hematology

127. Which cell type is predominant in acute myelogeneous leukemia?

A. lymphoblasts

B. myeloblasts

C. lymphocytes

128 / 209

Category: Hematology

128. Which of the following stains is used in distinguishing acute leukemias of myeloid origin from the monocytic origin?

A. Myeloperoxidase (MPO)

B. Periodic acid-Schiff (PAS)

C. Nonspecific esterase stains

129 / 209

Category: Hematology

129. What is the primary site for pre-T cell differentiation?

A. Liver

B. Spleen

C. Thymus

D. Bone marrow

130 / 209

Category: Hematology

130. Granulocytic cells will stain positive in which of the following stains?

A. Myeloperoxidase (MPO), Sudan black B, and Specific esterase stain

B. Myeloperoxidase (MPO), Periodic acid-Schiff (PAS), and non- specific esterase stain

C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains

131 / 209

Category: Hematology

131. Which of the following cell type will stain negative in Myeloperoxidase (MPO) stains?

A. Granulocytic cells

B. Auer rods stain

C. Lymphocytic cells

132 / 209

Category: Hematology

132. Which test is used to differentiate Warm autoimmune hemolytic anemia (WAIHA) from hereditary spherocytosis?

A. MCHC may be >37 g/dL

B. Increased osmotic fragility

C. Increased Bilirubin

D. Positive direct antiglobulin test (DAT)

133 / 209

Category: Hematology

133. Blood loss caused by gastrointestinal bleeding is classified as

A. Chronic blood loss

B. Reticulocytosis

C. Acute blood loss

134 / 209

Category: Hematology

134. What is the average lifespan of a normal red blood cell ?

A. 90 days

B. 180 days

C. 120 days

D. 60 days

135 / 209

Category: Hematology

135. Which gene mutation is implicated in Essential thrombocythemia (ET)?

A. JAK2 oncogene

B. t(8;11)

C. t(8;14)

D. BCR/ABL oncogene

136 / 209

Category: Hematology

136. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia?

A. Low Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

B. High Leukocyte Alkaline Phosphatase (LAP) score in chronic myelogenous leukemia

C. High Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

D. Philadelphia chromosome, t (9; 22) score in leukemoid reaction

137 / 209

Category: Hematology

137. A 25-year-old woman complains to his physician of extreme fatigue. Her CBC results are as follows:


WBC	6.8 x 10^9/L
RBC	3.9 x 10^12/L
Hemoglobin	9.2 g/dL
Hematocrit	30%
MCV	77fl
MCH	24 pg
MCHC	31 g/dL

Serum Iron	Ferritin	RDW	TIBC	Prussian blue stain
Decreased	Decreased	Decreased	Increased	Absent iron stores

The results of the CBC and iron studies, in this case, are most characteristic of?

A. Iron deficiency

B. Megaloblastic anemia

C. Sideroblastic anemia

D. Anemia of chronic disease

138 / 209

Category: Hematology

138. Hgb C Disease/Hgb CC is caused by substitution of glutamic acid with..

A. Lysine

B. Valine

C. Leucine

D. Glycine

139 / 209

Category: Hematology

139. What is the MCV?


Hemoglobin	14.9 g/dL
RBC	4.84 x 10^12/L
Hematocrit	44.4%

A. 104fL

B. 79fL

C. 91.7fl

D. 99fL

140 / 209

Category: Hematology

140. A 27-year-old woman complains to his physician of pain and fatigue. Her results are as follows:

WBC 5.4 x 10^9/L

RBC 3.9 x 10^12/L

Hemoglobin 8.2 g/dL

Hematocrit 28%

MCV 72 fL

MCHC 29.3 g/dL

ESR increased

Serum iron and total iron-binding capacity (TIBC) both decreased

Serum ferritin slightly elevated.

Presence of Prussian-blue-stainable iron in bone marrow was also noted.

Based her laboratory result, what is the cause of anemia?

A. Sideroblastic anemia

B. Anemia of Chronic Inflammation

C. Iron-deficiency anemia

D. Megaloblastic anemia

141 / 209

Category: Hematology

141. Which of the following stain is used in the diagnosis of Hairy cell leukemia?

A. Periodic acid-Schiff (PAS)

B. Nonspecific esterase stains

C. Sudan Black

D. Tartrate-resistant acid phosphatase stain (TRAP)

142 / 209

Category: Hematology

142. What is this cell?

A. Macrophages

B. Monocytes

C. Plasma cell

D. Reactive Lymphocytes

143 / 209

Category: Hematology

143. Which of the following characterizes iron deficiency anemia?

A. Decreased serum iron, increased transferrin saturation, normal ferritin

B. Increased serum iron, decreased transferrin saturation, decreased ferritin

C. Decreased serum iron, decreased ferritin and Increased TIBC

D. Increased serum transferrin, increased ferritin, and decreased Total iron binding capacity (TIBC)

144 / 209

Category: Hematology

144. Which classification is based on cellular morphology and cytochemical stain results?

A. French-American-British (FAB)

B. World Health Organization (WHO)

C. Cancer Association Method

145 / 209

Category: Hematology

145. What is the genetic translocation for FAB M2 (AML with maturation)?

A. t(15;17)

B. t(8;21)

C. t(8;14)

D. t(11;17)

146 / 209

Category: Hematology

146. A neutrophil disorder caused by mutations in the LYST gene and associated oculocutaneous albinism is ?

A. Pelger Huet Anomaly

B. Chediak-Higashi syndrome

C. May-Hegglin anomaly

D. Chronic granulomatous disease (CGD)

147 / 209

Category: Hematology

147. Programmed cell death is called ?

A. Cell biopsy

B. Necrosis

C. Gangrene

D. Apoptosis

148 / 209

Category: Hematology

148. What is the normal ratio of myeloid to erythroid precursors in the bone marrow (M:E ratio)?

A. 2:1

B. 3:1

C. 5:1

D. 1:1

149 / 209

Category: Hematology

149. What is the MCH?


Hemoglobin	14.1 g/dL
RBC	4.12 x 10^12/L
Hematocrit	41.3%

A. 34.2pg

B. 29.2pg

C. 32.2pg

D. 27.2pg

150 / 209

Category: Hematology

150. What is this cell?

A. Elliptocytes

B. Dacrocytes

C. Red blood cells

D. Spherocytes

151 / 209

Category: Hematology

151. Which of the following is the most common cause of iron deficiency?

A. Bleeding

B. Increased need

C. Inadequate diet

D. Pregnancy

152 / 209

Category: Hematology

152. What structure do methylene blue stain?

A. DNA

B. RNA

C. Hemoglobin

D. DNA and RNA

153 / 209

Category: Hematology

153. What are the two primary lymphoid tissues ?

A. Spleen and liver

B. Thymus and liver

C. Bone marrow and spleen

D. Bone marrow and thymus

154 / 209

Category: Hematology

154. In what condition would an LAP score of 180 most likely be found?

A. Bacterial septicemia

B. paroxysmal nocturnal hemoglobinuria

C. Polycythemia vera

D. Polycythemia vera and Bacterial septicemia

155 / 209

Category: Hematology

155. Which stain is used to enumerate reticulocytes ?

A. New methylene blue

B. Wright stain

C. Grams stain

D. Eosin stain

156 / 209

Category: Hematology

156. Which neutrophil abnormality is caused by mutation in Lamin B receptor and characterized by the presence of bilobed neutrophils ?

A. Pelger Huet Anomaly

B. Chediak-Higashi syndrome

C. May-Hegglin anomaly

D. Chronic granulomatous disease (CGD)

157 / 209

Category: Hematology

157. Which hemoglobin migrates with hemoglobins A2, C, and O on alkaline hemoglobin electropheroseis?

A. Hgb F

B. Hgb C

C. Hgb SC

D. Hgb E

158 / 209

Category: Hematology

158. Which of the following characterizes Vitamin B12 deficiency Anemia?

A. Decreased methylmalonic acid (MMA), Increased homocysteine

B. Increased methylmalonic acid (MMA), Increased homocysteine

C. Decreased methylmalonic acid (MMA), Decreased homocysteine

D. Decreased methylmalonic acid (MMA), Increased homocysteine

159 / 209

Category: Hematology

159. What is the pH of blood?

A. 7.25-7.45

B. 7.30-7.45

C. 7.32-7.49

D. 7.35-7.45

160 / 209

Category: Hematology

160. Which of the following cell markers are seen in B cell malignancy?

A. CD19, and CD20 positive

B. CD2, and CD4 positive

C. CD2, CD19, and CD20 positive

D. CD4, CD19, and CD20 positive

161 / 209

Category: Hematology

161. Which hemolytic anemia is caused due to a deficiency of the enzyme ADAMTS 13?

A. Paroxysmal nocturnal hemoglobinuria (PNH)

B. Hemolytic uremic syndrome (HUS)

C. Microangiopathic hemolytic anemias (MAHAs)

D. Thrombotic thrombocytopenic purpura (TTP)uremic syndrome (HUS)

162 / 209

Category: Hematology

162. Total iron binding capacity (TIBC) measures

A. Amount of transferrin

B. Amount of iron that transferrin can bind

C. Hepcidin

D. Ferritin

163 / 209

Category: Hematology

163. Which hemolytic anemia occurs most often in children following E. coli infection?

A. Paroxysmal nocturnal hemoglobinuria (PNH)

B. Hemolytic uremic syndrome (HUS)

C. Microangiopathic hemolytic anemias (MAHAs)

D. Thrombotic thrombocytopenic purpura (TTP)

164 / 209

Category: Hematology

164. Which erythrocyte metabolic pathway generates NADPH ?

A. Embden-Meyerhof

B. Hexose monophosphate

C. Rapoport-Luebering

D. Methemoglobin reductase

165 / 209

Category: Hematology

165. Which stain is useful in the diagnosis of acute monocytic leukemia (FAB M5)?

A. Myeloperoxidase (MPO)

B. Periodic acid-Schiff (PAS)

C. Nonspecific esterase stains

D. Sudan Black

166 / 209

Category: Hematology

166. Which of the following is an acquired membrane defect in which the red cell membrane has increased sensitivity for complement binding?

A. Pyruvate kinase (PK) deficiency

B. G6PD (glucose-6-phosphate dehydrogenase) deficiency

C. Hereditary spherocytosis

D. Paroxysmal nocturnal hemoglobinuria (PNH)

167 / 209

Category: Hematology

167. In what condition would an LAP score of 10 most likely be found?

A. Bacterial septicemia

B. Late pregnancy

C. Polycythemia vera

D. Chronic myelogenous leukemia

168 / 209

Category: Hematology

168. Calculate percent transferrin

Serum iron is 22 μg/dL

TIBC is 180 μg/dL

A. 17%

B. 25%

C. 12%

D. 15%

169 / 209

Category: Hematology

169. What is a true increase in the number of lymphocytes called ?

A. Absolute lymphocytosis

B. Absolute lymphopenia

C. Relative lymphocytosis

D. Absolute polycythemia

170 / 209

Category: Hematology

170. Antigen-dependent lymphopoiesis occurs in secondary lymphoid tissue located in

A. Liver and spleen

B. Spleen and kidney

C. Peyer’s patches and spleen

D. Thymus and bone marrow

171 / 209

Category: Hematology

171. Deficiency of intrinsic factors causes?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Lead poisoning

D. Pernicious anemia

172 / 209

Category: Hematology

172. This abnormality is caused by mutation in LYST gene, what is this cell?

A. Gaucher Disease

B. May Hegglin Anomally

C. Alder Anomaly

D. Chediak Higashi

173 / 209

Category: Hematology

173. Which erythrocyte metabolic pathway generates adenosine triphosphate (ATP) through glycolysis?

A. Methemoglobin reductase

B. Rapoport-Luebering

C. Hexose monophosphate

D. Embden-Meyerhof

174 / 209

Category: Hematology

174. Which of the following is not classified as a myeloproliferative disorder?

A. Polycythemia vera

B. Essential thrombocythemia

C. Seizary Syndrome

D. Chronic myelogenous leukemia