Hematology Question Bank

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Hematology Question Bank

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Category: Hematology

1. Which of the following is a lipid storage disorder caused by deficiency in glucocerebrosidase

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2. The presence of the chromosomal abnormality t(15;17) with disseminated intravascular coagulation (DIC) is diagnostic of?

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3. Which of the following stain is used to visualize iron granules in RBCs ?

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4. Howell-Jolly bodies are composed of 

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5.  Burkitt lymphoma is associated with which of the following virus?

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6. Which type of anemia is associated with hypersegmented neutrophils?

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7. Defective nuclear maturation commonly results in the production of red cells that are ?

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8. World Health Organization (WHO) defines acute leukemia as?

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9. Pancytopenia is seen in which type of anemia?

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10. Which disorder occurs when glutamic acid is replaced by valine at position 6 on both beta chains.?

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11. Which stain is useful in the diagnosis of erythroleukemia (FAB M6) and acute lymphoblastic leukemia?

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12. Which type of anemia will cause iron overload?

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13. Which of the following inclusions is only visible with supravital stain?

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14. This rod is associated with acute promyelocytic leukemia(AML). Identify the cell?

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15. Identify the cell

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16. Basophilia is associated with?

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17. What is this cell?

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18. Hgb D Disease is caused by substitution of glutamic acid with.

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19. Which of the following stains are used to differentiate blasts of acute myelogenous leukemias (AMLs) from acute lymphoblastic leukemia (ALLs)?

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20. Neutrophils with 5 or more lobes are called ?

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21. What is this cell?

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22. Which of the following is associated with a “shift to the right” in the oxygen dissociation curve of hemoglobin ?

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23. What term describes a mature red blood cell that contains iron granules ?

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24. Hemoglobinopathies are inherited disorders caused by

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25. What is the primary site for pre-B cell differentiation ?

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26. What is the MCHC?

Hemoglobin 11.1 g/dL
RBC 3.65 x 10^12/L
Hematocrit 32.5%

 

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27. Basophilia is associated with ?

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28. Di Guglielmo syndrome is also classified as?

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29. Which macrocytic anemia affects the Central Nervous System?

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30. Which of the following test is used to measure bone marrow erythropoiesis?

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31. What is the MCV?

Hemoglobin 11.1 g/dL
RBC 3.65 x 10^12/L
Hematocrit 32.5%

 

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32. A block in the protoporphyrin pathway resulting in defective hemoglobin synthesis is characteristic of which type of anemia?

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33. What is the genetic translocation in chronic myelogenous leukemia (CML)?

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34. Impaired DNA metabolism is characteristic of which type of anemia?

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35. What does the term “poikilocytosis” mean?

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36. What is the primary site of hematopoiesis in the third month of gestation?

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37. A sudden loss of blood from traumatic injuries is..

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38. Which of the following is the most commonly used routine stain for blood smear ?

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39. What is the MCHC?

Hemoglobin 14.1 g/dL
RBC 4.12 x 10^12/L
Hematocrit 41.3%

 

 

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40. Chronic myeloproliferative disorders terminate in?

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41. The most common cause of aplastic anemia is?

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42. What is this cell?

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43. Which test is used to differentiate chronic myelogenous leukemia (CML) from a neutrophilic leukemoid reaction (NLR)?

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44. Hemoglobin A2 consists of ?

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45. What is this cell?

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46. Decrease in absolute number of neutrophils is called ?

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47. An aggressive form of cutaneous T-cell lymphoma is?

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48.   Which erythrocyte metabolic pathway generates 2,3-bisphosphoglycerate ?

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49. Adult hemoglobin consists of ?

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50. What is this cell?

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51. What are the stages of granulocyte development ?

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52. Which of the following anemia is associated with dwarfism and mental retardation?

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53. Hemoglobin F consists of  ?

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54. What is the MCV?

Hemoglobin 14.1 g/dL
RBC 4.12 x 10^12/L
Hematocrit 41.3%

 

 

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55. What is the MCH?

Hemoglobin 11.1 g/dL
RBC 3.65 x 10^12/L
Hematocrit 32.5%

 

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56. What is this cell multi-lobed cells called?

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57. In Waldenstrom macroglobulinemia which immunoglobin is increasingly produced?

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58. What substance has a greater affinity for hemoglobin than oxygen ?

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59. What is the structure of the hemoglobin molecule ? 

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60. Which type of anemia would you see ringed sideroblasts?

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61. What does the term “anisocytosis” mean?

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62. What is the first type of blood cell produced by the developing embryo?

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63. What is a true increase in the number of lymphocytes called?

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64. Which lymphoma has Reed-Sternberg cells?

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65. Which classification for hematopoietic malignancy is the accepted standard for diagnosis?

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66. What is an excessive accumulation of iron in body tissues called?

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67. Which of the following test is used to measure bone marrow erythropoiesis?

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68. The majority of iron found in an adult is a constituent of

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69. What is an increase in the percentage of lymphocytes called ?

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70. What is the primary site of hematopoiesis in the first month of gestation?

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71. What is the process of blood cell formation called?

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72. Which of the following disorders is associated with left shift, toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score ?

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73. Which stain is used for reticulocyte count ?

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74. What is the oxidation state of iron in Hemoglobin ?

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75. What red cell morphologic abnormality have unevenly pointed projections and associated with abetalipoproteinemia

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76. Which gene mutation is implicated in polycythemia?

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77. Which of the following is diagnostic of Multiple myeloma?

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78. Which stain is used for reticulocyte count?

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79. What is the expected result of a solubility test for patients with Hgb SS disease?

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80. What is this cell?

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81. Which of the following red blood cell morphology abnormalities is associated hemoglobinopathies?

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82. Which of the following disorder is associated with left shift with toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score?

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83. Senescent RBCs are phagocytized by macrophages in the liver or spleen and removed through 

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84. Which of the following protein stimulates red blood cell production?

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85. Which chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

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86. Which gene mutation is associated with chronic myelogenous leukemia?

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87. Which hemoglobin forms are incapable of oxygen transport ?

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88. Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

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89. Pappenheimer bodies are composed of ?

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90. Impaired DNA metabolism is characteristic of which type of anemia ?

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91. Which of the following stain is used to visualize iron granules in RBCs?

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92. What red cell morphologic abnormality has evenly spaced round projections and is associated with pyruvate kinase deficiency 

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93. Which malignant disorder is associated with left shift with myelocytes the predominate cell?

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94. Thalassemias are the result of a?

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95. Which of the following conditions is most commonly associated with pica?

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96. French-American-British (FAB) defines acute leukemia as?

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97. What does Wright’s stain consist of ?

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98. An increased number of immature cell types in the peripheral blood is 

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99. Diphyllobothrium latum is associated with the development of?

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100. Which protein regulates iron homeostasis ?

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101. Microcytic, hypochromic red cells are most often associated with impaired

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102. Which of the following factors will result in an immediate increase in oxygen delivery to the tissues ? 

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103. What is the pH of blood ?

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104. Which of the following is the major transport protein of iron ?

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105. Which of the following red blood cell precursors is the last stage to undergo mitosis?

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106. Which of the following is the most commonly used routine stain for blood smear?

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107. Which term describes a decrease in all blood cell lines?

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108. What is the major storage form of iron?

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109. Which cell type is predominant in acute lymphoblastic leukemia?

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110. Decreased haptoglobin is indicative of 

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111. Which of the following differentiates non-megaloblastic macrocytic anemias from megaloblastic anemias?

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112. Which hemoglobin migrates with Hgb S and Hgb G on alkaline hemoglobin electrophoresis?

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113. A cutaneous lymphoma that causes skin itching and ulcerative tumor are called?

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114. What are the three stages of hematopoiesis?

CD13, CD33 positive (myeloid) and CD14 positive (monocytes)

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115. Which of the following cell markers is positive in acute myelomonocytic leukemia (AMML; FAB M4)?

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116. What is an increase in the percentage of lymphocytes called?

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117. Impaired release of storage iron due to increased hepcidin levels will result in ?

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118. Defective hemoglobin synthesis due to a block in the protoporphyrin pathway will result in which type of anemia?

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119. Which of the following is a true red cell aplasia?

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120. What is the primary site of hematopoiesis in the fifth month of gestation?

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121. Which abnormal red blood cell is seen in abetalipoproteinemia?

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122. Which of the following is a lipid storage disorder caused by deficiency in sphingomyelinase, associated with foamy bone marrow appearance ?

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123. Impaired DNA metabolism is characteristic of which type of anemia?

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124. What is this cell?

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125. Which of the following acquired hemolytic disorder causes intravascular hemolysis, presents with thrombocytopenia and schistocytes in peripheral blood smear?

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126. In normocytic/normochromic anemia reticulocyte is

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127.  Which cell type is predominant in acute myelogeneous leukemia?

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128. Which of the following stains is used in distinguishing acute leukemias of myeloid origin from the monocytic origin?

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129. What is the primary site for pre-T cell differentiation?

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130. Granulocytic cells will stain positive in which of the following stains?

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131. Which of the following cell type will stain negative in Myeloperoxidase (MPO) stains?

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132. Which test is used to differentiate Warm autoimmune hemolytic anemia (WAIHA) from hereditary spherocytosis?

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133. Blood loss caused by gastrointestinal bleeding is classified as

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134. What is the average lifespan of a normal red blood cell ?

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135. Which gene mutation is implicated in Essential thrombocythemia (ET)?

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136. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia?

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137. A 25-year-old woman complains to his physician of extreme fatigue. Her CBC results are as follows: 

WBC 6.8 x 10^9/L  
RBC 3.9 x 10^12/L  
Hemoglobin 9.2 g/dL
Hematocrit 30%
MCV 77fl
MCH 24 pg
MCHC 31 g/dL

 

Serum Iron Ferritin RDW TIBC Prussian blue stain
Decreased Decreased Decreased  Increased Absent iron stores

The results of the CBC and iron studies, in this case, are most characteristic of?

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138. Hgb C Disease/Hgb CC is caused by substitution of glutamic acid with..

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139. What is the MCV?

Hemoglobin 14.9 g/dL
RBC 4.84 x 10^12/L
Hematocrit 44.4%

 

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140. A 27-year-old woman complains to his physician of pain and fatigue. Her results are as follows: 

WBC 5.4 x 10^9/L 

RBC 3.9 x 10^12/L 

Hemoglobin 8.2 g/dL

Hematocrit 28%

MCV 72 fL

MCHC 29.3 g/dL

ESR increased

Serum iron and total iron-binding capacity (TIBC) both decreased

Serum ferritin slightly elevated. 

Presence of Prussian-blue-stainable iron in bone marrow was also noted.

Based her laboratory result, what is the cause of anemia?

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141. Which of the following stain is used in the diagnosis of Hairy cell leukemia?

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142. What is this cell?

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143. Which of the following characterizes iron deficiency anemia?

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144. Which classification is based on cellular morphology and cytochemical stain results?

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145. What is the genetic translocation for FAB M2 (AML with maturation)?

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146. A neutrophil disorder caused by mutations in the LYST gene and associated oculocutaneous albinism is ?

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147. Programmed cell death is called ?

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148. What is the normal ratio of myeloid to erythroid precursors in the bone marrow (M:E ratio)?

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149. What is the MCH?

Hemoglobin 14.1 g/dL
RBC 4.12 x 10^12/L
Hematocrit 41.3%

 

 

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150. What is this cell?

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151. Which of the following is the most common cause of iron deficiency?

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152. What structure do methylene blue stain?

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153. What are the two primary lymphoid tissues ?

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154. In what condition would an LAP score of 180 most likely be found?

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155. Which stain is used to enumerate reticulocytes ?

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156. Which neutrophil abnormality is caused by mutation in Lamin B receptor and characterized by the presence of bilobed neutrophils ?

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157. Which hemoglobin migrates  with hemoglobins A2, C, and O on alkaline hemoglobin electropheroseis?

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158. Which of the following characterizes Vitamin B12 deficiency Anemia?

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159. What is the pH of blood?

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160. Which of the following cell markers are seen in B cell malignancy?

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161. Which hemolytic anemia is caused due to a deficiency of the enzyme ADAMTS 13?

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162. Total iron binding capacity (TIBC) measures 

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163. Which hemolytic anemia occurs most often in children following E. coli infection?

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164. Which erythrocyte metabolic pathway generates NADPH ?

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165. Which stain is useful in the diagnosis of acute monocytic leukemia (FAB M5)?

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166. Which of the following is an acquired membrane defect in which the red cell membrane has increased sensitivity for complement binding?

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167. In what condition would an LAP score of 10 most likely be found?

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168. Calculate percent transferrin 

Serum iron is 22 μg/dL

 TIBC is 180 μg/dL

 

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169. What is a true increase in the number of lymphocytes called ?

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170. Antigen-dependent lymphopoiesis occurs in secondary lymphoid tissue located in 

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171. Deficiency of intrinsic factors causes?

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172. This abnormality is caused by mutation in LYST gene, what is this cell?

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173. Which erythrocyte metabolic pathway generates adenosine triphosphate (ATP) through glycolysis?

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174. Which of the following is not classified as a myeloproliferative disorder?