Hematology Question Bank 123456789101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778798081828384858687888990919293949596979899100101102103104105106107108109110111112113114115116117118119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209 0% 0 votes, 0 avg 9 GOOD LUCK WELL DONE Created by quizshellHematology Question Bank 1 / 209 Category: Hematology 1. Which of the following is a lipid storage disorder caused by deficiency in glucocerebrosidase A. Niemann-Pick disease B. Gaucher disease C. Alder normally D. Chronic granulomatous disease (CGD) 2 / 209 Category: Hematology 2. The presence of the chromosomal abnormality t(15;17) with disseminated intravascular coagulation (DIC) is diagnostic of? A. Acute myeloblastic leukemia without maturation (FAB type Ml) B. Acute myeloblastic leukemia with maturation (FAB type M2) C. Acute promyelocytic leukemia (FAB type M3) D. Acute myelomonocytic leukemia (FAB type M4) 3 / 209 Category: Hematology 3. Which of the following stain is used to visualize iron granules in RBCs ? A. Wright’s stain B. Supravital stain C. New methylene Blue D. Prussian blue 4 / 209 Category: Hematology 4. Howell-Jolly bodies are composed of A. Vitamin K B. RNA C. Iron granules D. DNA 5 / 209 Category: Hematology 5. Burkitt lymphoma is associated with which of the following virus? A. Polio Virus B. Rotavirus C. Coxcakie Virus D. Epstein Barr Virus 6 / 209 Category: Hematology 6. Which type of anemia is associated with hypersegmented neutrophils? A. Sideroblastic anemia B. Megaloblastic anemia C. Microcytic anemia D. Thalassemia 7 / 209 Category: Hematology 7. Defective nuclear maturation commonly results in the production of red cells that are ? A. Normocytic B. Hypochromic C. Macrocytic D. Microcytic 8 / 209 Category: Hematology 8. World Health Organization (WHO) defines acute leukemia as? A. >20% bone marrow blasts. B. >30% bone marrow blasts. C. >70% bone marrow blasts. D. >50% bone marrow blasts. 9 / 209 Category: Hematology 9. Pancytopenia is seen in which type of anemia? A. Iron deficiency anemia B. Sideroblastic anemia C. Aplastic anemia D. Anemia of chronic inflammation 10 / 209 Category: Hematology 10. Which disorder occurs when glutamic acid is replaced by valine at position 6 on both beta chains.? A. Hgb E B. Hgb SC C. Sickle Cell Disease (Hgb SS) D. Hgb C 11 / 209 Category: Hematology 11. Which stain is useful in the diagnosis of erythroleukemia (FAB M6) and acute lymphoblastic leukemia? A. Myeloperoxidase (MPO) B. Periodic acid-Schiff (PAS) C. Nonspecific esterase stains D. Sudan Black 12 / 209 Category: Hematology 12. Which type of anemia will cause iron overload? A. Thalassemia B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 13 / 209 Category: Hematology 13. Which of the following inclusions is only visible with supravital stain? A. Dohle bodies B. Pappenheimer bodies C. Basophilic stippling D. Heinz bodies 14 / 209 Category: Hematology 14. This rod is associated with acute promyelocytic leukemia(AML). Identify the cell? A. Howell Jolly Bodies B. Auer rods C. Plasma cell D. Reactive Lymphocytes 15 / 209 Category: Hematology 15. Identify the cell A. Microcytic normochromic red blood cells B. Microcytic hypochromic red blood cells C. Macrocytic red blood cells D. Normochromic red blood cells 16 / 209 Category: Hematology 16. Basophilia is associated with? A. Type I hypersensitivity reactions B. Leukemoid reaction (NLR) C. Chronic myelogenous leukemia D. Type I hypersensitivity reactions and chronic myelogenous leukemia 17 / 209 Category: Hematology 17. What is this cell? A. Dacrocytes B. Reticulocyte C. Target cells D. Elliptocytes 18 / 209 Category: Hematology 18. Hgb D Disease is caused by substitution of glutamic acid with. A. Lysine B. Valine C. Leucine D. Glycine 19 / 209 Category: Hematology 19. Which of the following stains are used to differentiate blasts of acute myelogenous leukemias (AMLs) from acute lymphoblastic leukemia (ALLs)? A. Myeloperoxidase (MPO) and Sudan black B B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS) C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains 20 / 209 Category: Hematology 20. Neutrophils with 5 or more lobes are called ? A. Multisegmented neutrophils B. Hypersegmented neutrophils C. Hyposegmented neutrophils D. Monosegmented neutrophils 21 / 209 Category: Hematology 21. What is this cell? A. Dacrocytes B. Reticulocyte C. Codocytes D. Elliptocytes 22 / 209 Category: Hematology 22. Which of the following is associated with a “shift to the right” in the oxygen dissociation curve of hemoglobin ? A. Decreased oxygen release B. Increased pH, high 2,3-bisphosphoglycerate and increased body temperature C. Decreased pH, high 2, 3-bisphosphoglycerate and elevated temperature D. Decreased carbon release 23 / 209 Category: Hematology 23. What term describes a mature red blood cell that contains iron granules ? A. Basophillic stippling B. Siderocyte C. Howell Jolly D. Ringed sideroblast 24 / 209 Category: Hematology 24. Hemoglobinopathies are inherited disorders caused by A. Amino acid substitutions B. Block in NADPH C. Abnormal Hemoglobin structure D. Peptide mutation 25 / 209 Category: Hematology 25. What is the primary site for pre-B cell differentiation ? A. Liver B. Spleen C. Thymus D. Bone marrow 26 / 209 Category: Hematology 26. What is the MCHC? Hemoglobin 11.1 g/dL RBC 3.65 x 10^12/L Hematocrit 32.5% A. 32.2g/dL B. 24.2g/dL C. 34.2g/dL D. 36.2g/dL 27 / 209 Category: Hematology 27. Basophilia is associated with ? A. Type I hypersensitivity reactions B. Leukemoid reaction (NLR) C. Type I hypersensitivity reactions and chronic myelogenous leukemia D. Chronic myelogenous leukemia 28 / 209 Category: Hematology 28. Di Guglielmo syndrome is also classified as? A. Acute megakaryocytic leukemia (AMegL; FAB M7) B. Acute erythroleukemia; FAB M6 C. Acute myelomonocytic leukemia ;AMML; FAB M4 D. Acute promyelocytic leukemia (APL); FAB M3 29 / 209 Category: Hematology 29. Which macrocytic anemia affects the Central Nervous System? A. Iron deficiency anemia B. Sideroblastic anemia C. Folate deficiency D. Vitamin B12 deficiency 30 / 209 Category: Hematology 30. Which of the following test is used to measure bone marrow erythropoiesis? A. Hams Sugar test B. Erythrocyte Sedimentation Rate C. Reticulocyte count D. Cell count 31 / 209 Category: Hematology 31. What is the MCV? Hemoglobin 11.1 g/dL RBC 3.65 x 10^12/L Hematocrit 32.5% A. 84fL B. 79fL C. 89fL D. 92fL 32 / 209 Category: Hematology 32. A block in the protoporphyrin pathway resulting in defective hemoglobin synthesis is characteristic of which type of anemia? A. Thalassemia B. Porphyrias C. Iron-deficiency anemia D. Megaloblastic anemia 33 / 209 Category: Hematology 33. What is the genetic translocation in chronic myelogenous leukemia (CML)? A. t(15;17) B. t(9;22) C. t(8;14); with a rearrangement of the MYC oncogene D. t(11;17) 34 / 209 Category: Hematology 34. Impaired DNA metabolism is characteristic of which type of anemia? A. Thalassemia B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 35 / 209 Category: Hematology 35. What does the term “poikilocytosis” mean? A. Variations in size B. Variations in shape C. Variation of central palor D. Variations in color 36 / 209 Category: Hematology 36. What is the primary site of hematopoiesis in the third month of gestation? A. Spleen B. Marrow of long bones C. Liver D. Yolk sac 37 / 209 Category: Hematology 37. A sudden loss of blood from traumatic injuries is.. A. Chronic blood loss B. Reticulocytosis C. Acute blood loss 38 / 209 Category: Hematology 38. Which of the following is the most commonly used routine stain for blood smear ? A. Prussian blue B. Supravital stain C. Wright’s stain D. New methylene Blue 39 / 209 Category: Hematology 39. What is the MCHC? Hemoglobin 14.1 g/dL RBC 4.12 x 10^12/L Hematocrit 41.3% A. 34.2g/dL B. 34.1g/dL C. 32.2g/dL D. 27.2g/dL 40 / 209 Category: Hematology 40. Chronic myeloproliferative disorders terminate in? A. Acute leukemia B. Chronic leukemia 41 / 209 Category: Hematology 41. The most common cause of aplastic anemia is? A. Idiopathic B. Diamond-Blackfan anemia C. Fanconi anemia D. Sideroblastic anemia 42 / 209 Category: Hematology 42. What is this cell? A. Hgb SS Crystals B. Hgb SC Crystals C. Hgb C Crystals D. Hgb E Crystals 43 / 209 Category: Hematology 43. Which test is used to differentiate chronic myelogenous leukemia (CML) from a neutrophilic leukemoid reaction (NLR)? A. Periodic acid-Schiff (PAS) B. Nonspecific esterase stains C. Sudan Black D. Leukocyte alkaline phosphatase (LAP) 44 / 209 Category: Hematology 44. Hemoglobin A2 consists of ? A. Two alpha- and two beta-globin chains B. Two alpha- and four beta-globin chains C. Two alpha- and two delta-globin chains D. Four alpha- and two beta-globin chains 45 / 209 Category: Hematology 45. What is this cell? A. Basophilic stipplings B. Reticulocyte C. Washed red blood cells D. Artifact 46 / 209 Category: Hematology 46. Decrease in absolute number of neutrophils is called ? A. Eosinophilia B. Leukopenia C. Neutropenia D. Leukocytosis 47 / 209 Category: Hematology 47. An aggressive form of cutaneous T-cell lymphoma is? A. Sezary syndrome B. Mycosis fungoides C. Reed-Sternberg syndrome D. Chronic myelogenous leukemia (CML) 48 / 209 Category: Hematology 48. Which erythrocyte metabolic pathway generates 2,3-bisphosphoglycerate ? A. Embden-Meyerhof B. Hexose monophosphate C. Rapoport-Luebering D. Methemoglobin reductase 49 / 209 Category: Hematology 49. Adult hemoglobin consists of ? A. Hgb F contains two alpha- and four beta-globin chains B. Hgb A contains four alpha- and two beta-globin chains C. Hgb A contains two alpha- and two beta-globin chains D. Hgb F contains three alpha- and four beta-globin chains 50 / 209 Category: Hematology 50. What is this cell? A. Macrophages B. Monocytes C. Plasma cell D. Reactive Lymphocytes 51 / 209 Category: Hematology 51. What are the stages of granulocyte development ? A. Myeloblast, Promyelocyte, Myelocyte, Metamyelocyte, band neutrophils B. Myeloblast, Myelocyte, Promyelocyte, Metamyelocyte, band neutrophils C. Myeloblast, Myelocyte, Metamyelocyte, Promyelocyte, band neutrophils D. Myeloblast, Myelocyte, Metamyelocyte, band neutrophils 52 / 209 Category: Hematology 52. Which of the following anemia is associated with dwarfism and mental retardation? A. Diamond-Blackfan anemia B. Fanconi anemia C. Sideroblastic anemia D. Aplasia 53 / 209 Category: Hematology 53. Hemoglobin F consists of ? A. Two alpha- and two beta-globin chains B. Two alpha- and two gamma-globin chains C. Two alpha- and two delta-globin chains D. Four alpha- and two beta-globin chains 54 / 209 Category: Hematology 54. What is the MCV? Hemoglobin 14.1 g/dL RBC 4.12 x 10^12/L Hematocrit 41.3% A. 104fL B. 79fL C. 100.2fL D. 99fL 55 / 209 Category: Hematology 55. What is the MCH? Hemoglobin 11.1 g/dL RBC 3.65 x 10^12/L Hematocrit 32.5% A. 31pg B. 33 pg C. 30.9pg D. 30.4pg 56 / 209 Category: Hematology 56. What is this cell multi-lobed cells called? A. Lymphocytes B. Segmented Neutrophils C. Monocytes D. Eosinophils 57 / 209 Category: Hematology 57. In Waldenstrom macroglobulinemia which immunoglobin is increasingly produced? A. IgM B. IgG C. IgA D. IgS 58 / 209 Category: Hematology 58. What substance has a greater affinity for hemoglobin than oxygen ? A. Carbon B. Carbon dioxide C. Carbonmonoxide D. Oxide 59 / 209 Category: Hematology 59. What is the structure of the hemoglobin molecule ? A. Two heme groups, two globin chains B. Four heme groups, two globin chains C. Four heme groups, four globin chains D. Two heme groups, four globin chains 60 / 209 Category: Hematology 60. Which type of anemia would you see ringed sideroblasts? A. Thalassemia B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 61 / 209 Category: Hematology 61. What does the term “anisocytosis” mean? A. Variations in size B. Variations in shape C. Variation of central palor D. Variations in color 62 / 209 Category: Hematology 62. What is the first type of blood cell produced by the developing embryo? A. Thrombocyte B. Granulocyte C. Lymphocytes D. Erythrocytes 63 / 209 Category: Hematology 63. What is a true increase in the number of lymphocytes called? A. Absolute lymphopenia B. Absolute lymphocytosis C. Relative lymphocytosis D. Absolute polycythemia 64 / 209 Category: Hematology 64. Which lymphoma has Reed-Sternberg cells? A. Hodgkin lymphoma B. Non-Hodgkin lymphoma C. Acute lymphocytic leukemia (CLL) D. Chronic myelogenous leukemia (CML) 65 / 209 Category: Hematology 65. Which classification for hematopoietic malignancy is the accepted standard for diagnosis? A. French-American-British (FAB) B. World Health Organization (WHO) C. Cancer Association Method 66 / 209 Category: Hematology 66. What is an excessive accumulation of iron in body tissues called? A. Hematoma B. Heme toxicity C. Hematopenia D. Hemochromatosis 67 / 209 Category: Hematology 67. Which of the following test is used to measure bone marrow erythropoiesis? A. Hams Sugar test B. Reticulocyte count C. Erythrocyte Sedimentation Rate D. Cell count 68 / 209 Category: Hematology 68. The majority of iron found in an adult is a constituent of A. Haptoglobin B. Myoglobin C. Hemoglobin D. Propyria 69 / 209 Category: Hematology 69. What is an increase in the percentage of lymphocytes called ? A. Absolute lymphopenia B. Relative lymphocytosis C. Absolute lymphocytosis D. Absolute polycythemia 70 / 209 Category: Hematology 70. What is the primary site of hematopoiesis in the first month of gestation? A. Spleen B. Marrow of long bones C. Liver D. Yolk sac 71 / 209 Category: Hematology 71. What is the process of blood cell formation called? A. Hemochromatosis B. Apotosis C. Hematopoiesis D. Mitosis 72 / 209 Category: Hematology 72. Which of the following disorders is associated with left shift, toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score ? A. Basophilic stipplings B. Chronic myelogenous leukemia C. Neutrophilic leukemoid reaction (NLR) D. Acute myelogenous leukemia 73 / 209 Category: Hematology 73. Which stain is used for reticulocyte count ? A. Wright’s stain B. Supravital stain C. New methylene Blue D. Prussian blue 74 / 209 Category: Hematology 74. What is the oxidation state of iron in Hemoglobin ? A. Oxide state B. Ferrous state C. Peroxide state D. Ferric state 75 / 209 Category: Hematology 75. What red cell morphologic abnormality have unevenly pointed projections and associated with abetalipoproteinemia A. Spherocytes B. Echinocytes C. Dacrocytes D. Acanthocytes 76 / 209 Category: Hematology 76. Which gene mutation is implicated in polycythemia? A. JAK2 oncogene B. t(8;11) C. BCR/ABL oncogene D. t(11;17) 77 / 209 Category: Hematology 77. Which of the following is diagnostic of Multiple myeloma? A. "M"-spike in the gamma-globulin region in serum electrophoresis B. Bence Jones proteins in the urine C. Excessive production IgM (macroglobulin) D. production of excessive IgG (macroglobulin) E. A ,B and D 78 / 209 Category: Hematology 78. Which stain is used for reticulocyte count? A. Prussian blue B. Wright’s stain C. Supravital stain D. New methylene Blue 79 / 209 Category: Hematology 79. What is the expected result of a solubility test for patients with Hgb SS disease? A. Negative B. Positive 80 / 209 Category: Hematology 80. What is this cell? A. Dacrocytes B. Reticulocyte C. Sickle Cells D. Elliptocytes 81 / 209 Category: Hematology 81. Which of the following red blood cell morphology abnormalities is associated hemoglobinopathies? A. Ovalocytes B. Target cells C. Echinocytes D. Acanthocytes 82 / 209 Category: Hematology 82. Which of the following disorder is associated with left shift with toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score? A. Basophilic stipplings B. Neutrophilic leukemoid reaction (NLR) C. Chronic myelogenous leukemia D. Acute myelogenous leukemia 83 / 209 Category: Hematology 83. Senescent RBCs are phagocytized by macrophages in the liver or spleen and removed through A. Extravascular hemolysis B. Intravascular hemolysis C. Necrosis D. Cell degeneration 84 / 209 Category: Hematology 84. Which of the following protein stimulates red blood cell production? A. Erythropoietin B. Transferrin C. Hemopexin D. Prealbumin 85 / 209 Category: Hematology 85. Which chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)? A. t(15;17) B. t(8;11) C. t(8;14) D. t(11;17) 86 / 209 Category: Hematology 86. Which gene mutation is associated with chronic myelogenous leukemia? A. JAK2 oncogene B. t(8;11) C. t(8;14) D. BCR/ABL oncogene 87 / 209 Category: Hematology 87. Which hemoglobin forms are incapable of oxygen transport ? A. Deoxyhemoglobin and carboxyhemoglobin B. Methemoglobin and deoxyhemoglobin C. Oxyhemoglobin and deoxyhemoglobin D. Carboxyhemoglobin and methemoglobin 88 / 209 Category: Hematology 88. Which of the following is found in biopsies of individuals with Hodgkin lymphoma? A. Reed-Sternberg cells B. Mycosis fungoides C. Sezary syndrome D. Smudge cells 89 / 209 Category: Hematology 89. Pappenheimer bodies are composed of ? A. Vitamin K B. RNA C. Iron granules D. DNA 90 / 209 Category: Hematology 90. Impaired DNA metabolism is characteristic of which type of anemia ? A. Thalassemia B. Sideroblastic anemia C. Megaloblastic anemia D. Iron-deficiency anemia 91 / 209 Category: Hematology 91. Which of the following stain is used to visualize iron granules in RBCs? A. Prussian blue B. Wright’s stain C. Supravital stain D. New methylene Blue 92 / 209 Category: Hematology 92. What red cell morphologic abnormality has evenly spaced round projections and is associated with pyruvate kinase deficiency A. Spherocytes B. Echinocytes C. Dacrocytes D. Acanthocytes 93 / 209 Category: Hematology 93. Which malignant disorder is associated with left shift with myelocytes the predominate cell? A. Acute myelogeneous leukemia B. Chronic myelogenous leukemia C. Acute promyelocytic leukemia (APL); FAB M3 D. Acute megakaryocytic leukemia (AMegL; FAB M7) 94 / 209 Category: Hematology 94. Thalassemias are the result of a? A. Structural defect in the globin portion of hemoglobin B. Quantitative defect in globin-chain synthesis C. Qualitative defect in globin-chain structure D. Qualitative defect in heme structure 95 / 209 Category: Hematology 95. Which of the following conditions is most commonly associated with pica? A. Anemia of chronic inflammation B. Alpha thalassemia C. Iron deficiency D. Lead poisoning 96 / 209 Category: Hematology 96. French-American-British (FAB) defines acute leukemia as? A. >20% bone marrow blasts. B. >30% bone marrow blasts. C. >70% bone marrow blasts. D. >50% bone marrow blasts. 97 / 209 Category: Hematology 97. What does Wright’s stain consist of ? A. Methylene blue and cresyl green B. Methylene blue and neutral red C. Methylene blue and eosin D. Methylene blue and Giemsa stain 98 / 209 Category: Hematology 98. An increased number of immature cell types in the peripheral blood is A. Cell apoptosis B. Cell degeneration C. Right shift D. Left shift 99 / 209 Category: Hematology 99. Diphyllobothrium latum is associated with the development of? A. Iron deficiency anemia B. Sideroblastic anemia C. Lead poisoning D. Vitamin B12 deficiency 100 / 209 Category: Hematology 100. Which protein regulates iron homeostasis ? A. Hemosiderin B. Transferrin C. Hepcidin D. Hemopexin 101 / 209 Category: Hematology 101. Microcytic, hypochromic red cells are most often associated with impaired A. DNA synthesis B. Hemoglobin synthesis C. RNA metabolism D. Enzyme metabolism 102 / 209 Category: Hematology 102. Which of the following factors will result in an immediate increase in oxygen delivery to the tissues ? A. decreased body temperature B. low 2,3-bisphosphoglycerate (2,3-BPG) level C. Decreased pH D. Decreased carbon release 103 / 209 Category: Hematology 103. What is the pH of blood ? A. 7.35-7.45 B. 7.25-7.45 C. 7.30-7.45 D. 7.32-7.49 104 / 209 Category: Hematology 104. Which of the following is the major transport protein of iron ? A. Transferrin B. Ferritin C. Hemosiderin D. Haptoglobin 105 / 209 Category: Hematology 105. Which of the following red blood cell precursors is the last stage to undergo mitosis? A. Band neutrophils B. Promyelocyte C. Myelocyte D. Segmented neutrophils 106 / 209 Category: Hematology 106. Which of the following is the most commonly used routine stain for blood smear? A. Prussian blue B. Wright’s stain C. Supravital stain D. New methylene Blue 107 / 209 Category: Hematology 107. Which term describes a decrease in all blood cell lines? A. Pancytopenia B. Cellopenia C. Reticulocytosis D. Nucleopenia 108 / 209 Category: Hematology 108. What is the major storage form of iron? A. Transferrin B. Hemosiderin C. Ferritin D. Hemachromatin 109 / 209 Category: Hematology 109. Which cell type is predominant in acute lymphoblastic leukemia? A. lymphoblasts B. myeloblasts C. granulocytes 110 / 209 Category: Hematology 110. Decreased haptoglobin is indicative of A. Extravascular hemolysis B. Intravascular hemolysis C. Intramedullary hematopoiesis D. Intermedullary hematopoiesis 111 / 209 Category: Hematology 111. Which of the following differentiates non-megaloblastic macrocytic anemias from megaloblastic anemias? A. Oval erythrocytes in non-megaloblastic macrocytic B. Round erythrocytes in megaloblastic anemias C. Hypersegmented neutrophil in non-megaloblastic macrocytic D. Round erythrocytes in non-megaloblastic macrocytic 112 / 209 Category: Hematology 112. Which hemoglobin migrates with Hgb S and Hgb G on alkaline hemoglobin electrophoresis? A. Hgb F B. Hgb C C. Hgb D D. Hgb SC 113 / 209 Category: Hematology 113. A cutaneous lymphoma that causes skin itching and ulcerative tumor are called? A. Mycosis fungoides B. Reed-Sternberg syndrome C. Waldenstrom macroglobulinemia 114 / 209 Category: Hematology 114. What are the three stages of hematopoiesis? A. Meroblastic phase, hepatic phase, and medullary phase B. Mesoblastic phase, primitive phase, and medullary phase C. Primitive phase, definitive phase and hepatic phase D. Mesoblastic phase, hepatic phase, and medullary phase CD13, CD33 positive (myeloid) and CD14 positive (monocytes) 115 / 209 Category: Hematology 115. Which of the following cell markers is positive in acute myelomonocytic leukemia (AMML; FAB M4)? A. CD13, CD15, and CD33 B. CD13, CD33 positive and CD14 positive C. CD45 and CD71 116 / 209 Category: Hematology 116. What is an increase in the percentage of lymphocytes called? A. Absolute lymphopenia B. Absolute lymphocytosis C. Relative lymphocytosis D. Absolute polycythemia 117 / 209 Category: Hematology 117. Impaired release of storage iron due to increased hepcidin levels will result in ? A. Thalassemia B. Sideroblastic anemia C. Anemia of Chronic Inflammation D. Iron-deficiency anemia 118 / 209 Category: Hematology 118. Defective hemoglobin synthesis due to a block in the protoporphyrin pathway will result in which type of anemia? A. Thalassemia B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 119 / 209 Category: Hematology 119. Which of the following is a true red cell aplasia? A. Diamond-Blackfan anemia B. Fanconi anemia C. Sideroblastic anemia D. Aplasia 120 / 209 Category: Hematology 120. What is the primary site of hematopoiesis in the fifth month of gestation? A. Spleen B. Marrow of long bones C. Liver D. Yolk sac 121 / 209 Category: Hematology 121. Which abnormal red blood cell is seen in abetalipoproteinemia? A. Spherocytes B. Acanthocytes C. Echinocytes D. Codocytes 122 / 209 Category: Hematology 122. Which of the following is a lipid storage disorder caused by deficiency in sphingomyelinase, associated with foamy bone marrow appearance ? A. Niemann-Pick disease B. Gaucher disease C. Alder normally D. Chronic granulomatous disease (CGD) 123 / 209 Category: Hematology 123. Impaired DNA metabolism is characteristic of which type of anemia? A. Iron deficiency anemia B. Sideroblastic anemia C. Lead poisoning D. Vitamin B12 deficiency 124 / 209 Category: Hematology 124. What is this cell? A. Dacrocytes B. Schistocytes C. Echinocytes D. Acanthocytes 125 / 209 Category: Hematology 125. Which of the following acquired hemolytic disorder causes intravascular hemolysis, presents with thrombocytopenia and schistocytes in peripheral blood smear? A. Microangiopathic hemolytic anemias (MAHAs) B. Paroxysmal nocturnal hemoglobinuria (PNH) C. Hemolytic uremic syndrome (HUS) D. Thrombotic thrombocytopenic purpura (TTP) E. All of the above 126 / 209 Category: Hematology 126. In normocytic/normochromic anemia reticulocyte is A. Increased B. Decreased C. Normal 127 / 209 Category: Hematology 127. Which cell type is predominant in acute myelogeneous leukemia? A. lymphoblasts B. myeloblasts C. lymphocytes 128 / 209 Category: Hematology 128. Which of the following stains is used in distinguishing acute leukemias of myeloid origin from the monocytic origin? A. Myeloperoxidase (MPO) B. Periodic acid-Schiff (PAS) C. Nonspecific esterase stains 129 / 209 Category: Hematology 129. What is the primary site for pre-T cell differentiation? A. Liver B. Spleen C. Thymus D. Bone marrow 130 / 209 Category: Hematology 130. Granulocytic cells will stain positive in which of the following stains? A. Myeloperoxidase (MPO), Sudan black B, and Specific esterase stain B. Myeloperoxidase (MPO), Periodic acid-Schiff (PAS), and non- specific esterase stain C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains 131 / 209 Category: Hematology 131. Which of the following cell type will stain negative in Myeloperoxidase (MPO) stains? A. Granulocytic cells B. Auer rods stain C. Lymphocytic cells 132 / 209 Category: Hematology 132. Which test is used to differentiate Warm autoimmune hemolytic anemia (WAIHA) from hereditary spherocytosis? A. MCHC may be >37 g/dL B. Increased osmotic fragility C. Increased Bilirubin D. Positive direct antiglobulin test (DAT) 133 / 209 Category: Hematology 133. Blood loss caused by gastrointestinal bleeding is classified as A. Chronic blood loss B. Reticulocytosis C. Acute blood loss 134 / 209 Category: Hematology 134. What is the average lifespan of a normal red blood cell ? A. 90 days B. 180 days C. 120 days D. 60 days 135 / 209 Category: Hematology 135. Which gene mutation is implicated in Essential thrombocythemia (ET)? A. JAK2 oncogene B. t(8;11) C. t(8;14) D. BCR/ABL oncogene 136 / 209 Category: Hematology 136. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia? A. Low Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction B. High Leukocyte Alkaline Phosphatase (LAP) score in chronic myelogenous leukemia C. High Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction D. Philadelphia chromosome, t (9; 22) score in leukemoid reaction 137 / 209 Category: Hematology 137. A 25-year-old woman complains to his physician of extreme fatigue. Her CBC results are as follows: WBC 6.8 x 10^9/L RBC 3.9 x 10^12/L Hemoglobin 9.2 g/dL Hematocrit 30% MCV 77fl MCH 24 pg MCHC 31 g/dL Serum Iron Ferritin RDW TIBC Prussian blue stain Decreased Decreased Decreased Increased Absent iron stores The results of the CBC and iron studies, in this case, are most characteristic of? A. Iron deficiency B. Megaloblastic anemia C. Sideroblastic anemia D. Anemia of chronic disease 138 / 209 Category: Hematology 138. Hgb C Disease/Hgb CC is caused by substitution of glutamic acid with.. A. Lysine B. Valine C. Leucine D. Glycine 139 / 209 Category: Hematology 139. What is the MCV? Hemoglobin 14.9 g/dL RBC 4.84 x 10^12/L Hematocrit 44.4% A. 104fL B. 79fL C. 91.7fl D. 99fL 140 / 209 Category: Hematology 140. A 27-year-old woman complains to his physician of pain and fatigue. Her results are as follows: WBC 5.4 x 10^9/L RBC 3.9 x 10^12/L Hemoglobin 8.2 g/dL Hematocrit 28% MCV 72 fL MCHC 29.3 g/dL ESR increased Serum iron and total iron-binding capacity (TIBC) both decreased Serum ferritin slightly elevated. Presence of Prussian-blue-stainable iron in bone marrow was also noted. Based her laboratory result, what is the cause of anemia? A. Sideroblastic anemia B. Anemia of Chronic Inflammation C. Iron-deficiency anemia D. Megaloblastic anemia 141 / 209 Category: Hematology 141. Which of the following stain is used in the diagnosis of Hairy cell leukemia? A. Periodic acid-Schiff (PAS) B. Nonspecific esterase stains C. Sudan Black D. Tartrate-resistant acid phosphatase stain (TRAP) 142 / 209 Category: Hematology 142. What is this cell? A. Macrophages B. Monocytes C. Plasma cell D. Reactive Lymphocytes 143 / 209 Category: Hematology 143. Which of the following characterizes iron deficiency anemia? A. Decreased serum iron, increased transferrin saturation, normal ferritin B. Increased serum iron, decreased transferrin saturation, decreased ferritin C. Decreased serum iron, decreased ferritin and Increased TIBC D. Increased serum transferrin, increased ferritin, and decreased Total iron binding capacity (TIBC) 144 / 209 Category: Hematology 144. Which classification is based on cellular morphology and cytochemical stain results? A. French-American-British (FAB) B. World Health Organization (WHO) C. Cancer Association Method 145 / 209 Category: Hematology 145. What is the genetic translocation for FAB M2 (AML with maturation)? A. t(15;17) B. t(8;21) C. t(8;14) D. t(11;17) 146 / 209 Category: Hematology 146. A neutrophil disorder caused by mutations in the LYST gene and associated oculocutaneous albinism is ? A. Pelger Huet Anomaly B. Chediak-Higashi syndrome C. May-Hegglin anomaly D. Chronic granulomatous disease (CGD) 147 / 209 Category: Hematology 147. Programmed cell death is called ? A. Cell biopsy B. Necrosis C. Gangrene D. Apoptosis 148 / 209 Category: Hematology 148. What is the normal ratio of myeloid to erythroid precursors in the bone marrow (M:E ratio)? A. 2:1 B. 3:1 C. 5:1 D. 1:1 149 / 209 Category: Hematology 149. What is the MCH? Hemoglobin 14.1 g/dL RBC 4.12 x 10^12/L Hematocrit 41.3% A. 34.2pg B. 29.2pg C. 32.2pg D. 27.2pg 150 / 209 Category: Hematology 150. What is this cell? A. Elliptocytes B. Dacrocytes C. Red blood cells D. Spherocytes 151 / 209 Category: Hematology 151. Which of the following is the most common cause of iron deficiency? A. Bleeding B. Increased need C. Inadequate diet D. Pregnancy 152 / 209 Category: Hematology 152. What structure do methylene blue stain? A. DNA B. RNA C. Hemoglobin D. DNA and RNA 153 / 209 Category: Hematology 153. What are the two primary lymphoid tissues ? A. Spleen and liver B. Thymus and liver C. Bone marrow and spleen D. Bone marrow and thymus 154 / 209 Category: Hematology 154. In what condition would an LAP score of 180 most likely be found? A. Bacterial septicemia B. paroxysmal nocturnal hemoglobinuria C. Polycythemia vera D. Polycythemia vera and Bacterial septicemia 155 / 209 Category: Hematology 155. Which stain is used to enumerate reticulocytes ? A. New methylene blue B. Wright stain C. Grams stain D. Eosin stain 156 / 209 Category: Hematology 156. Which neutrophil abnormality is caused by mutation in Lamin B receptor and characterized by the presence of bilobed neutrophils ? A. Pelger Huet Anomaly B. Chediak-Higashi syndrome C. May-Hegglin anomaly D. Chronic granulomatous disease (CGD) 157 / 209 Category: Hematology 157. Which hemoglobin migrates with hemoglobins A2, C, and O on alkaline hemoglobin electropheroseis? A. Hgb F B. Hgb C C. Hgb SC D. Hgb E 158 / 209 Category: Hematology 158. Which of the following characterizes Vitamin B12 deficiency Anemia? A. Decreased methylmalonic acid (MMA), Increased homocysteine B. Increased methylmalonic acid (MMA), Increased homocysteine C. Decreased methylmalonic acid (MMA), Decreased homocysteine D. Decreased methylmalonic acid (MMA), Increased homocysteine 159 / 209 Category: Hematology 159. What is the pH of blood? A. 7.25-7.45 B. 7.30-7.45 C. 7.32-7.49 D. 7.35-7.45 160 / 209 Category: Hematology 160. Which of the following cell markers are seen in B cell malignancy? A. CD19, and CD20 positive B. CD2, and CD4 positive C. CD2, CD19, and CD20 positive D. CD4, CD19, and CD20 positive 161 / 209 Category: Hematology 161. Which hemolytic anemia is caused due to a deficiency of the enzyme ADAMTS 13? A. Paroxysmal nocturnal hemoglobinuria (PNH) B. Hemolytic uremic syndrome (HUS) C. Microangiopathic hemolytic anemias (MAHAs) D. Thrombotic thrombocytopenic purpura (TTP)uremic syndrome (HUS) 162 / 209 Category: Hematology 162. Total iron binding capacity (TIBC) measures A. Amount of transferrin B. Amount of iron that transferrin can bind C. Hepcidin D. Ferritin 163 / 209 Category: Hematology 163. Which hemolytic anemia occurs most often in children following E. coli infection? A. Paroxysmal nocturnal hemoglobinuria (PNH) B. Hemolytic uremic syndrome (HUS) C. Microangiopathic hemolytic anemias (MAHAs) D. Thrombotic thrombocytopenic purpura (TTP) 164 / 209 Category: Hematology 164. Which erythrocyte metabolic pathway generates NADPH ? A. Embden-Meyerhof B. Hexose monophosphate C. Rapoport-Luebering D. Methemoglobin reductase 165 / 209 Category: Hematology 165. Which stain is useful in the diagnosis of acute monocytic leukemia (FAB M5)? A. Myeloperoxidase (MPO) B. Periodic acid-Schiff (PAS) C. Nonspecific esterase stains D. Sudan Black 166 / 209 Category: Hematology 166. Which of the following is an acquired membrane defect in which the red cell membrane has increased sensitivity for complement binding? A. Pyruvate kinase (PK) deficiency B. G6PD (glucose-6-phosphate dehydrogenase) deficiency C. Hereditary spherocytosis D. Paroxysmal nocturnal hemoglobinuria (PNH) 167 / 209 Category: Hematology 167. In what condition would an LAP score of 10 most likely be found? A. Bacterial septicemia B. Late pregnancy C. Polycythemia vera D. Chronic myelogenous leukemia 168 / 209 Category: Hematology 168. Calculate percent transferrin Serum iron is 22 μg/dL TIBC is 180 μg/dL A. 17% B. 25% C. 12% D. 15% Transferrin Saturation %= Serum iron x 100 / TIBC 22 X 100 / 180 169 / 209 Category: Hematology 169. What is a true increase in the number of lymphocytes called ? A. Absolute lymphocytosis B. Absolute lymphopenia C. Relative lymphocytosis D. Absolute polycythemia 170 / 209 Category: Hematology 170. Antigen-dependent lymphopoiesis occurs in secondary lymphoid tissue located in A. Liver and spleen B. Spleen and kidney C. Peyer’s patches and spleen D. Thymus and bone marrow 171 / 209 Category: Hematology 171. Deficiency of intrinsic factors causes? A. Iron deficiency anemia B. Sideroblastic anemia C. Lead poisoning D. Pernicious anemia 172 / 209 Category: Hematology 172. This abnormality is caused by mutation in LYST gene, what is this cell? A. Gaucher Disease B. May Hegglin Anomally C. Alder Anomaly D. Chediak Higashi 173 / 209 Category: Hematology 173. Which erythrocyte metabolic pathway generates adenosine triphosphate (ATP) through glycolysis? A. Methemoglobin reductase B. Rapoport-Luebering C. Hexose monophosphate D. Embden-Meyerhof 174 / 209 Category: Hematology 174. Which of the following is not classified as a myeloproliferative disorder? A. Polycythemia vera B. Essential thrombocythemia C. Seizary Syndrome D. Chronic myelogenous leukemia