Hematology Test Bank Leave a Comment / By quizshell / July 27, 2022 123456789101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778798081828384858687888990919293949596979899100101102103104105106107108109110111112113114115116117118119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210 0% 0 votes, 0 avg 6 Good Luck WELL DONE Created by quizshellHematology Question Bank CD13, CD33 positive (myeloid) and CD14 positive (monocytes) 1 / 210 Category: Hematology 1. Which of the following cell markers is positive in acute myelomonocytic leukemia (AMML; FAB M4)? A. CD13, CD15, and CD33 B. CD13, CD33 positive and CD14 positive C. CD45 and CD71 2 / 210 Category: Hematology 2. What is this cell? A. Dacrocytes B. Schistocytes C. Echinocytes D. Acanthocytes 3 / 210 Category: Hematology 3. Which of the following is not classified as a myeloproliferative disorder? A. Polycythemia vera B. Essential thrombocythemia C. Seizary Syndrome D. Chronic myelogenous leukemia 4 / 210 Category: Hematology 4. What is the MCH? Hemoglobin 14.9 g/dL RBC 4.84 x 10^12/L Hematocrit 44.4% A. 30.8pg B. 34pg C. 36pg D. 29pg 5 / 210 Category: Hematology 5. Which of the following red blood cell precursors is the last stage to undergo mitosis? A. Band neutrophils B. Promyelocyte C. Myelocyte D. Segmented neutrophils 6 / 210 Category: Hematology 6. Which of the following stains are used to differentiate blasts of acute myelogenous leukemias (AMLs) from acute lymphoblastic leukemia (ALLs)? A. Myeloperoxidase (MPO) and Sudan black B B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS) C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains 7 / 210 Category: Hematology 7. Granulocytic cells will stain positive in which of the following stains? A. Myeloperoxidase (MPO), Sudan black B, and Specific esterase stain B. Myeloperoxidase (MPO), Periodic acid-Schiff (PAS), and non- specific esterase stain C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains 8 / 210 Category: Hematology 8. Chronic myeloproliferative disorders terminate in? A. Acute leukemia B. Chronic leukemia 9 / 210 Category: Hematology 9. Hemoglobin A2 consists of ? A. Two alpha- and two beta-globin chains B. Two alpha- and four beta-globin chains C. Two alpha- and two delta-globin chains D. Four alpha- and two beta-globin chains 10 / 210 Category: Hematology 10. What are the stages of erythrocyte maturation from the earliest recognizable stage? A. Pronormoblast, normoblast, Polychromatophilic normoblast Orthochromic normoblast, Reticulocyte B. Pronormoblast, Basophilic normoblast, Polychromatophilic normoblast normoblast, Reticulocyte C. Pronormoblast, Basophilic normoblast, Polychromatophilic normoblast, Orthochromic normoblast, Reticulocyte D. Rubriblast, metarubricyte, reticulocyte, Basophilic normoblast 11 / 210 Category: Hematology 11. Which hemoglobin migrates with with hemoglobins A2, E, and O on alkaline hemoglobin electropheroseis? A. Hgb F B. Hgb C C. Hgb SC D. Hgb E 12 / 210 Category: Hematology 12. What is a true increase in the number of lymphocytes called ? A. Absolute lymphocytosis B. Absolute lymphopenia C. Relative lymphocytosis D. Absolute polycythemia 13 / 210 Category: Hematology 13. A 21-year-old woman complains to his physician of fatigue, dizziness, and craving for ice. Her results are as follows: Based on her laboratory result, what is the cause of anemia? WBC 4.8 x 10^9/L RBC 3.75 x 10^12/L Hemoglobin 9.8 g/dL Hematocrit 29% MCV 77.3 fL MCHC 33.8 g/dL Serum iron and ferritin is decreased Elevated total iron-binding capacity (TIBC) Blood smear shows microcytic hypochromic red blood cells A. Anemia of Chronic Inflammation B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 14 / 210 Category: Hematology 14. Which of the following test is used to measure bone marrow erythropoiesis? A. Hams Sugar test B. Reticulocyte count C. Erythrocyte Sedimentation Rate D. Cell count 15 / 210 Category: Hematology 15. What is the average lifespan of a normal red blood cell ? A. 90 days B. 180 days C. 120 days D. 60 days 16 / 210 Category: Hematology 16. Hemoglobin F consists of ? A. Two alpha- and two beta-globin chains B. Two alpha- and two gamma-globin chains C. Two alpha- and two delta-globin chains D. Four alpha- and two beta-globin chains 17 / 210 Category: Hematology 17. Basophilic stippling is composed of A. Vitamin K B. RNA C. Iron granules D. DNA 18 / 210 Category: Hematology 18. Howell-Jolly bodies are composed of A. Vitamin K B. RNA C. Iron granules D. DNA 19 / 210 Category: Hematology 19. Impaired DNA metabolism is characteristic of which type of anemia? A. Iron deficiency anemia B. Sideroblastic anemia C. Lead poisoning D. Vitamin B12 deficiency 20 / 210 Category: Hematology 20. What term describes a mature red blood cell that contains iron granules ? A. Basophillic stippling B. Siderocyte C. Howell Jolly D. Ringed sideroblast 21 / 210 Category: Hematology 21. Hgb D Disease is caused by substitution of glutamic acid with. A. Lysine B. Valine C. Leucine D. Glycine 22 / 210 Category: Hematology 22. Which classification is based on cellular morphology and cytochemical stain results? A. French-American-British (FAB) B. World Health Organization (WHO) C. Cancer Association Method 23 / 210 Category: Hematology 23. Diphyllobothrium latum is associated with the development of? A. Iron deficiency anemia B. Sideroblastic anemia C. Lead poisoning D. Vitamin B12 deficiency 24 / 210 Category: Hematology 24. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia? A. Low Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction B. High Leukocyte Alkaline Phosphatase (LAP) score in chronic myelogenous leukemia C. High Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction D. Philadelphia chromosome, t (9; 22) score in leukemoid reaction 25 / 210 Category: Hematology 25. A 25-year-old woman complains to his physician of extreme fatigue. Her CBC results are as follows: WBC 6.8 x 10^9/L RBC 3.9 x 10^12/L Hemoglobin 9.2 g/dL Hematocrit 30% MCV 77fl MCH 24 pg MCHC 31 g/dL Serum Iron Ferritin RDW TIBC Prussian blue stain Decreased Decreased Decreased Increased Absent iron stores The results of the CBC and iron studies, in this case, are most characteristic of? A. Iron deficiency B. Megaloblastic anemia C. Sideroblastic anemia D. Anemia of chronic disease 26 / 210 Category: Hematology 26. Which of the following is found in biopsies of individuals with Hodgkin lymphoma? A. Reed-Sternberg cells B. Mycosis fungoides C. Sezary syndrome D. Smudge cells 27 / 210 Category: Hematology 27. Which of the following is the most commonly used routine stain for blood smear ? A. Prussian blue B. Supravital stain C. Wright's stain D. New methylene Blue 28 / 210 Category: Hematology 28. Which test is used to differentiate chronic myelogenous leukemia (CML) from a neutrophilic leukemoid reaction (NLR)? A. Periodic acid-Schiff (PAS) B. Nonspecific esterase stains C. Sudan Black D. Leukocyte alkaline phosphatase (LAP) 29 / 210 Category: Hematology 29. What is the primary site of hematopoiesis in the fifth month of gestation? A. Spleen B. Marrow of long bones C. Liver D. Yolk sac 30 / 210 Category: Hematology 30. In normocytic/normochromic anemia reticulocyte is A. Increased B. Decreased C. Normal 31 / 210 Category: Hematology 31. Increased LAP score is seen in? A. Chronic myelogenous leukemia (CML) B. Paroxysmal nocturnal hemoglobinuria C. Neutrophilic leukemoid reaction 32 / 210 Category: Hematology 32. What is the primary site of hematopoiesis in the third month of gestation? A. Spleen B. Marrow of long bones C. Liver D. Yolk sac 33 / 210 Category: Hematology 33. What is the most common enzyme deficiency in Embden Meyerhof Pathway? A. G6PD (glucose-6-phosphate dehydrogenase) deficiency B. Hereditary spherocytosis C. Pyruvate kinase (PK) deficiency D. Paroxysmal nocturnal hemoglobinuria (PNH) 34 / 210 Category: Hematology 34. What is the primary site for pre-T cell differentiation? A. Liver B. Spleen C. Thymus D. Bone marrow 35 / 210 Category: Hematology 35. What is the normal ratio of myeloid to erythroid precursors in the bone marrow (M:E ratio)? A. 2:1 B. 3:1 C. 5:1 D. 1:1 36 / 210 Category: Hematology 36. Which test is used to differentiate Warm autoimmune hemolytic anemia (WAIHA) from hereditary spherocytosis? A. MCHC may be >37 g/dL B. Increased osmotic fragility C. Increased Bilirubin D. Positive direct antiglobulin test (DAT) 37 / 210 Category: Hematology 37. What is the pH of blood ? A. 7.35-7.45 B. 7.25-7.45 C. 7.30-7.45 D. 7.32-7.49 38 / 210 Category: Hematology 38. Which cell type is predominant in acute lymphoblastic leukemia? A. lymphoblasts B. myeloblasts C. granulocytes 39 / 210 Category: Hematology 39. What is the structure of the hemoglobin molecule ? A. Two heme groups, two globin chains B. Four heme groups, two globin chains C. Four heme groups, four globin chains D. Two heme groups, four globin chains 40 / 210 Category: Hematology 40. Which type of hemoglobin is produced in the mesoblastic phase? A. Portland B. Hgb F C. Hgb A D. Portland, Gower I and Gower II 41 / 210 Category: Hematology 41. Antigen-dependent lymphopoiesis occurs in secondary lymphoid tissue located in A. Liver and spleen B. Spleen and kidney C. Peyer's patches and spleen D. Thymus and bone marrow 42 / 210 Category: Hematology 42. What is the genetic translocation for FAB M2 (AML with maturation)? A. t(15;17) B. t(8;21) C. t(8;14) D. t(11;17) 43 / 210 Category: Hematology 43. Which stain is used to enumerate reticulocytes ? A. New methylene blue B. Wright stain C. Grams stain D. Eosin stain 44 / 210 Category: Hematology 44. Which of the following conditions is most commonly associated with pica? A. Anemia of chronic inflammation B. Alpha thalassemia C. Iron deficiency D. Lead poisoning 45 / 210 Category: Hematology 45. What is the MCV? Hemoglobin 14.9 g/dL RBC 4.84 x 10^12/L Hematocrit 44.4% A. 104fL B. 79fL C. 91.7fl D. 99fL 46 / 210 Category: Hematology 46. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia ? A. Low Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction B. High Leukocyte Alkaline Phosphatase (LAP) score in chronic myelogenous leukemia C. High Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction D. Philadelphia chromosome, t (9; 22) score in leukemoid reaction 47 / 210 Category: Hematology 47. Which of the following acquired hemolytic disorder causes intravascular hemolysis, presents with thrombocytopenia and schistocytes in peripheral blood smear? A. Microangiopathic hemolytic anemias (MAHAs) B. Paroxysmal nocturnal hemoglobinuria (PNH) C. Hemolytic uremic syndrome (HUS) D. Thrombotic thrombocytopenic purpura (TTP) E. All of the above 48 / 210 Category: Hematology 48. Impaired DNA metabolism is characteristic of which type of anemia ? A. Thalassemia B. Sideroblastic anemia C. Megaloblastic anemia D. Iron-deficiency anemia 49 / 210 Category: Hematology 49. Basophilia is associated with? A. Type I hypersensitivity reactions B. Leukemoid reaction (NLR) C. Chronic myelogenous leukemia D. Type I hypersensitivity reactions and chronic myelogenous leukemia 50 / 210 Category: Hematology 50. Which hemolytic anemia is caused due to a deficiency of the enzyme ADAMTS 13? A. Paroxysmal nocturnal hemoglobinuria (PNH) B. Hemolytic uremic syndrome (HUS) C. Microangiopathic hemolytic anemias (MAHAs) D. Thrombotic thrombocytopenic purpura (TTP)uremic syndrome (HUS) 51 / 210 Category: Hematology 51. What is the MCH? Hemoglobin 14.1 g/dL RBC 4.12 x 10^12/L Hematocrit 41.3% A. 34.2pg B. 29.2pg C. 32.2pg D. 27.2pg 52 / 210 Category: Hematology 52. Auer rods will stain positive in which of the following stains? A. Myeloperoxidase (MPO) and Sudan black B B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS) C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains 53 / 210 Category: Hematology 53. Senescent RBCs are phagocytized by macrophages in the liver or spleen and removed through A. Extravascular hemolysis B. Intravascular hemolysis C. Necrosis D. Cell degeneration 54 / 210 Category: Hematology 54. Which protein regulates iron homeostasis ? A. Hemosiderin B. Transferrin C. Hepcidin D. Hemopexin 55 / 210 Category: Hematology 55. Which of the following clinical finding is associated with Hgb SS disease? A. Bone marrow erythroid hyperplasia B. Decreased haptoglobin C. Positive hemoglobin solubility D. All of the above 56 / 210 Category: Hematology 56. What is the MCHC? Hemoglobin 11.1 g/dL RBC 3.65 x 10^12/L Hematocrit 32.5% A. 32.2g/dL B. 24.2g/dL C. 34.2g/dL D. 36.2g/dL 57 / 210 Category: Hematology 57. Neutrophils with 5 or more lobes are called ? A. Multisegmented neutrophils B. Hypersegmented neutrophils C. Hyposegmented neutrophils D. Monosegmented neutrophils 58 / 210 Category: Hematology 58. Which stain is used for reticulocyte count ? A. Wright's stain B. Supravital stain C. New methylene Blue D. Prussian blue 59 / 210 Category: Hematology 59. Which of the following inclusions is only visible with supravital stain? A. Dohle bodies B. Pappenheimer bodies C. Basophilic stippling D. Heinz bodies 60 / 210 Category: Hematology 60. Which classification for hematopoietic malignancy is the accepted standard for diagnosis? A. French-American-British (FAB) B. World Health Organization (WHO) C. Cancer Association Method 61 / 210 Category: Hematology 61. Which of the following is the most commonly used routine stain for blood smear? A. Prussian blue B. Wright's stain C. Supravital stain D. New methylene Blue 62 / 210 Category: Hematology 62. What is the pH of blood? A. 7.25-7.45 B. 7.30-7.45 C. 7.32-7.49 D. 7.35-7.45 63 / 210 Category: Hematology 63. What is this cell? A. Macrophages B. Monocytes C. Plasma cell D. Reactive Lymphocytes 64 / 210 Category: Hematology 64. What is the primary site of hematopoiesis in the first month of gestation? A. Spleen B. Marrow of long bones C. Liver D. Yolk sac 65 / 210 Category: Hematology 65. Decrease in absolute number of neutrophils is called ? A. Eosinophilia B. Leukopenia C. Neutropenia D. Leukocytosis 66 / 210 Category: Hematology 66. What is the first type of blood cell produced by the developing embryo? A. Thrombocyte B. Granulocyte C. Lymphocytes D. Erythrocytes 67 / 210 Category: Hematology 67. What is the genetic translocation in chronic myelogenous leukemia (CML)? A. t(15;17) B. t(9;22) C. t(8;14); with a rearrangement of the MYC oncogene D. t(11;17) 68 / 210 Category: Hematology 68. What does Wright's stain consist of? A. Methylene blue and cresyl green B. Methylene blue and eosin C. Methylene blue and neutral red D. Methylene blue and Giemsa stain 69 / 210 Category: Hematology 69. Which neutrophil abnormality is caused by mutation in Lamin B receptor and characterized by the presence of bilobed neutrophils ? A. Pelger Huet Anomaly B. Chediak-Higashi syndrome C. May-Hegglin anomaly D. Chronic granulomatous disease (CGD) 70 / 210 Category: Hematology 70. Which of the following differentiates non-megaloblastic macrocytic anemias from megaloblastic anemias? A. Oval erythrocytes in non-megaloblastic macrocytic B. Round erythrocytes in megaloblastic anemias C. Hypersegmented neutrophil in non-megaloblastic macrocytic D. Round erythrocytes in non-megaloblastic macrocytic 71 / 210 Category: Hematology 71. Which gene mutation is implicated in polycythemia? A. JAK2 oncogene B. t(8;11) C. BCR/ABL oncogene D. t(11;17) 72 / 210 Category: Hematology 72. In Waldenstrom macroglobulinemia which immunoglobin is increasingly produced? A. IgM B. IgG C. IgA D. IgS 73 / 210 Category: Hematology 73. The majority of iron found in an adult is a constituent of A. Haptoglobin B. Myoglobin C. Hemoglobin D. Propyria 74 / 210 Category: Hematology 74. Blood loss caused by gastrointestinal bleeding is classified as A. Chronic blood loss B. Reticulocytosis C. Acute blood loss 75 / 210 Category: Hematology 75. What is an excessive accumulation of iron in body tissues called? A. Hematoma B. Heme toxicity C. Hematopenia D. Hemochromatosis 76 / 210 Category: Hematology 76. Impaired DNA metabolism is characteristic of which type of anemia? A. Thalassemia B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 77 / 210 Category: Hematology 77. Which cell transports oxygen and removes metabolic waste from the body ? A. White blood cells B. Platelets C. Red blood cells D. Plasma 78 / 210 Category: Hematology 78. French-American-British (FAB) defines acute leukemia as? A. >20% bone marrow blasts. B. >30% bone marrow blasts. C. >70% bone marrow blasts. D. >50% bone marrow blasts. 79 / 210 Category: Hematology 79. What substance has a greater affinity for hemoglobin than oxygen ? A. Carbon B. Carbon dioxide C. Carbonmonoxide D. Oxide 80 / 210 Category: Hematology 80. Programmed cell death is called ? A. Cell biopsy B. Necrosis C. Gangrene D. Apoptosis 81 / 210 Category: Hematology 81. A cutaneous lymphoma that causes skin itching and ulcerative tumor are called? A. Mycosis fungoides B. Reed-Sternberg syndrome C. Waldenstrom macroglobulinemia 82 / 210 Category: Hematology 82. An increased number of immature cell types in the peripheral blood is A. Cell apoptosis B. Cell degeneration C. Right shift D. Left shift 83 / 210 Category: Hematology 83. What does the term "poikilocytosis" mean? A. Variations in size B. Variations in shape C. Variation of central palor D. Variations in color 84 / 210 Category: Hematology 84. Which type of anemia is associated with hypersegmented neutrophils? A. Sideroblastic anemia B. Megaloblastic anemia C. Microcytic anemia D. Thalassemia 85 / 210 Category: Hematology 85. What structures do methylene blue stain? A. DNA B. RNA C. Hemoglobin D. DNA and RNA 86 / 210 Category: Hematology 86. Which of the following is the most common cause of iron deficiency? A. Bleeding B. Increased need C. Inadequate diet D. Pregnancy 87 / 210 Category: Hematology 87. The presence of the chromosomal abnormality t(15;17) with disseminated intravascular coagulation (DIC) is diagnostic of? A. Acute myeloblastic leukemia without maturation (FAB type Ml) B. Acute myeloblastic leukemia with maturation (FAB type M2) C. Acute promyelocytic leukemia (FAB type M3) D. Acute myelomonocytic leukemia (FAB type M4) 88 / 210 Category: Hematology 88. Which of the following characterizes sideroblastic anemia? A. Serum iron decreased, transferrin decreased B. Serum iron decreased, transferrin increased C. Serum iron normal, transferrin normal D. TIBC decreased, increased ferritin and serum iron 89 / 210 Category: Hematology 89. Which of the following protein stimulates red blood cell production? A. Erythropoietin B. Transferrin C. Hemopexin D. Prealbumin 90 / 210 Category: Hematology 90. Hemoglobinopathies are inherited disorders caused by A. Amino acid substitutions B. Block in NADPH C. Abnormal Hemoglobin structure D. Peptide mutation 91 / 210 Category: Hematology 91. Which of the following stain is used to visualize iron granules in RBCs? A. Prussian blue B. Wright's stain C. Supravital stain D. New methylene Blue 92 / 210 Category: Hematology 92. Defective hemoglobin synthesis due to a block in the protoporphyrin pathway will result in which type of anemia? A. Thalassemia B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 93 / 210 Category: Hematology 93. Which of the following stains is used in distinguishing acute leukemias of myeloid origin from the monocytic origin? A. Myeloperoxidase (MPO) B. Periodic acid-Schiff (PAS) C. Nonspecific esterase stains 94 / 210 Category: Hematology 94. Which of the following stain is used to visualize iron granules in RBCs ? A. Wright's stain B. Supravital stain C. New methylene Blue D. Prussian blue 95 / 210 Category: Hematology 95. Which hemoglobin migrates with hemoglobins A2, C, and O on alkaline hemoglobin electropheroseis? A. Hgb F B. Hgb C C. Hgb SC D. Hgb E 96 / 210 Category: Hematology 96. Microcytic, hypochromic red cells are most often associated with impaired A. DNA synthesis B. Hemoglobin synthesis C. RNA metabolism D. Enzyme metabolism 97 / 210 Category: Hematology 97. Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia? A. Chronic lymphocytic leukemia (CLL) B. Hairy cell leukemia (HCL) C. Acute lymphocytic leukemia (CLL) D. Chronic myelogenous leukemia (CML) 98 / 210 Category: Hematology 98. A 27-year-old woman complains to his physician of pain and fatigue. Her results are as follows: WBC 5.4 x 10^9/L RBC 3.9 x 10^12/L Hemoglobin 8.2 g/dL Hematocrit 28% MCV 72 fL MCHC 29.3 g/dL ESR increased Serum iron and total iron-binding capacity (TIBC) both decreased Serum ferritin slightly elevated. Presence of Prussian-blue-stainable iron in bone marrow was also noted. Based her laboratory result, what is the cause of anemia? A. Sideroblastic anemia B. Anemia of Chronic Inflammation C. Iron-deficiency anemia D. Megaloblastic anemia 99 / 210 Category: Hematology 99. A neutrophil disorder caused by mutations in the LYST gene and associated oculocutaneous albinism is ? A. Pelger Huet Anomaly B. Chediak-Higashi syndrome C. May-Hegglin anomaly D. Chronic granulomatous disease (CGD) 100 / 210 Category: Hematology 100. What are the three stages of hematopoiesis? A. Meroblastic phase, hepatic phase, and medullary phase B. Mesoblastic phase, primitive phase, and medullary phase C. Primitive phase, definitive phase and hepatic phase D. Mesoblastic phase, hepatic phase, and medullary phase 101 / 210 Category: Hematology 101. Which of the following disorder is associated with left shift with toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score? A. Basophilic stipplings B. Neutrophilic leukemoid reaction (NLR) C. Chronic myelogenous leukemia D. Acute myelogenous leukemia 102 / 210 Category: Hematology 102. What is the MCV? Hemoglobin 14.1 g/dL RBC 4.12 x 10^12/L Hematocrit 41.3% A. 104fL B. 79fL C. 100.2fL D. 99fL 103 / 210 Category: Hematology 103. Which of the following anemia is associated with dwarfism and mental retardation? A. Diamond-Blackfan anemia B. Fanconi anemia C. Sideroblastic anemia D. Aplasia 104 / 210 Category: Hematology 104. Impaired release of storage iron due to increased hepcidin levels will result in ? A. Thalassemia B. Sideroblastic anemia C. Anemia of Chronic Inflammation D. Iron-deficiency anemia 105 / 210 Category: Hematology 105. Which protein transports hemoglobin dimers resulting from intravascular hemolysis ? A. Hemopexin B. Albumin C. Haptoglobin D. Hemosiderin 106 / 210 Category: Hematology 106. Which of the following characterizes Vitamin B12 deficiency Anemia? A. Decreased methylmalonic acid (MMA), Increased homocysteine B. Increased methylmalonic acid (MMA), Increased homocysteine C. Decreased methylmalonic acid (MMA), Decreased homocysteine D. Decreased methylmalonic acid (MMA), Increased homocysteine 107 / 210 Category: Hematology 107. Which of the following is a lipid storage disorder caused by deficiency in glucocerebrosidase A. Niemann-Pick disease B. Gaucher disease C. Alder normally D. Chronic granulomatous disease (CGD) 108 / 210 Category: Hematology 108. Which of the following is diagnostic of Multiple myeloma? A. "M"-spike in the gamma-globulin region in serum electrophoresis B. Bence Jones proteins in the urine C. Excessive production IgM (macroglobulin) D. production of excessive IgG (macroglobulin) E. A ,B and D 109 / 210 Category: Hematology 109. What red cell morphologic abnormality has evenly spaced round projections and is associated with pyruvate kinase deficiency A. Spherocytes B. Echinocytes C. Dacrocytes D. Acanthocytes 110 / 210 Category: Hematology 110. Di Guglielmo syndrome is also classified as? A. Acute megakaryocytic leukemia (AMegL; FAB M7) B. Acute erythroleukemia; FAB M6 C. Acute myelomonocytic leukemia ;AMML; FAB M4 D. Acute promyelocytic leukemia (APL); FAB M3 111 / 210 Category: Hematology 111. This rod is associated with acute promyelocytic leukemia(AML). Identify the cell? A. Howell Jolly Bodies B. Auer rods C. Plasma cell D. Reactive Lymphocytes 112 / 210 Category: Hematology 112. Adult hemoglobin consists of ? A. Hgb F contains two alpha- and four beta-globin chains B. Hgb A contains four alpha- and two beta-globin chains C. Hgb A contains two alpha- and two beta-globin chains D. Hgb F contains three alpha- and four beta-globin chains 113 / 210 Category: Hematology 113. What is this cell? A. Dacrocytes B. Reticulocyte C. Target cells D. Elliptocytes 114 / 210 Category: Hematology 114. What is this cell multi-lobed cells called? A. Lymphocytes B. Segmented Neutrophils C. Monocytes D. Eosinophils 115 / 210 Category: Hematology 115. World Health Organization (WHO) defines acute leukemia as? A. >20% bone marrow blasts. B. >30% bone marrow blasts. C. >70% bone marrow blasts. D. >50% bone marrow blasts. 116 / 210 Category: Hematology 116. Which gene mutation is associated with chronic myelogenous leukemia? A. JAK2 oncogene B. t(8;11) C. t(8;14) D. BCR/ABL oncogene 117 / 210 Category: Hematology 117. Thalassemias are the result of a? A. Structural defect in the globin portion of hemoglobin B. Quantitative defect in globin-chain synthesis C. Qualitative defect in globin-chain structure D. Qualitative defect in heme structure 118 / 210 Category: Hematology 118. What is the MCV? Hemoglobin 11.1 g/dL RBC 3.65 x 10^12/L Hematocrit 32.5% A. 84fL B. 79fL C. 89fL D. 92fL 119 / 210 Category: Hematology 119. What hemoglobin is predominant at birth ? A. Portland B. Hgb F C. Gower I D. Gower II 120 / 210 Category: Hematology 120. What are the stages of granulocyte development ? A. Myeloblast, Promyelocyte, Myelocyte, Metamyelocyte, band neutrophils B. Myeloblast, Myelocyte, Promyelocyte, Metamyelocyte, band neutrophils C. Myeloblast, Myelocyte, Metamyelocyte, Promyelocyte, band neutrophils D. Myeloblast, Myelocyte, Metamyelocyte, band neutrophils 121 / 210 Category: Hematology 121. A sudden loss of blood from traumatic injuries is.. A. Chronic blood loss B. Reticulocytosis C. Acute blood loss 122 / 210 Category: Hematology 122. Which of the following cell type will stain negative in Myeloperoxidase (MPO) stains? A. Granulocytic cells B. Auer rods stain C. Lymphocytic cells 123 / 210 Category: Hematology 123. Which cell type is predominant in acute myelogeneous leukemia? A. lymphoblasts B. myeloblasts C. lymphocytes 124 / 210 Category: Hematology 124. A block in the protoporphyrin pathway resulting in defective hemoglobin synthesis is characteristic of which type of anemia? A. Thalassemia B. Porphyrias C. Iron-deficiency anemia D. Megaloblastic anemia 125 / 210 Category: Hematology 125. Which leukemia is characterized by a proliferation of megakaryoblasts and positivity for CD41, CD42, and CD61 by flow cytometry? A. Acute erythroleukemia; FAB M6 B. Acute myelomonocytic leukemia ;AMML; FAB M4 C. Acute promyelocytic leukemia (APL); FAB M3 D. Acute megakaryocytic leukemia (AMegL; FAB M7) 126 / 210 Category: Hematology 126. Which type of anemia would you see ringed sideroblasts? A. Thalassemia B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 127 / 210 Category: Hematology 127. Which of the following factors will result in an immediate increase in oxygen delivery to the tissues ? A. decreased body temperature B. low 2,3-bisphosphoglycerate (2,3-BPG) level C. Decreased pH D. Decreased carbon release 128 / 210 Category: Hematology 128. Which of the following cell markers are seen in B cell malignancy? A. CD19, and CD20 positive B. CD2, and CD4 positive C. CD2, CD19, and CD20 positive D. CD4, CD19, and CD20 positive 129 / 210 Category: Hematology 129. What is this cell? A. Basophilic stipplings B. Reticulocyte C. Washed red blood cells D. Artifact 130 / 210 Category: Hematology 130. Antigen-independent lymphopoiesis occurs in A. Liver and spleen B. Spleen and kidney C. Peyer's patches and spleen D. Thymus and bone marrow 131 / 210 Category: Hematology 131. What is the oxidation state of iron in Hemoglobin ? A. Oxide state B. Ferrous state C. Peroxide state D. Ferric state 132 / 210 Category: Hematology 132. What are the two primary lymphoid tissues ? A. Spleen and liver B. Thymus and liver C. Bone marrow and spleen D. Bone marrow and thymus 133 / 210 Category: Hematology 133. This abnormality is caused by mutation in LYST gene, what is this cell? A. Gaucher Disease B. May Hegglin Anomally C. Alder Anomaly D. Chediak Higashi 134 / 210 Category: Hematology 134. Which of the following is the major transport protein of iron ? A. Transferrin B. Ferritin C. Hemosiderin D. Haptoglobin 135 / 210 Category: Hematology 135. In what condition would an LAP score of 180 most likely be found? A. Bacterial septicemia B. paroxysmal nocturnal hemoglobinuria C. Polycythemia vera D. Polycythemia vera and Bacterial septicemia 136 / 210 Category: Hematology 136. Which inclusion is seen in G6PD (glucose-6-phosphate dehydrogenase) deficiency? A. Heinz bodies B. Ringed sideroblasts C. Howell jolly D. Pappenheimer bodies 137 / 210 Category: Hematology 137. Which of the following test is used to measure bone marrow erythropoiesis? A. Hams Sugar test B. Erythrocyte Sedimentation Rate C. Reticulocyte count D. Cell count 138 / 210 Category: Hematology 138. The most common cause of aplastic anemia is? A. Idiopathic B. Diamond-Blackfan anemia C. Fanconi anemia D. Sideroblastic anemia 139 / 210 Category: Hematology 139. Which term describes a decrease in all blood cell lines? A. Pancytopenia B. Cellopenia C. Reticulocytosis D. Nucleopenia 140 / 210 Category: Hematology 140. What is an increase in the percentage of lymphocytes called ? A. Absolute lymphopenia B. Relative lymphocytosis C. Absolute lymphocytosis D. Absolute polycythemia 141 / 210 Category: Hematology 141. Which macrocytic anemia affects the Central Nervous System? A. Iron deficiency anemia B. Sideroblastic anemia C. Folate deficiency D. Vitamin B12 deficiency 142 / 210 Category: Hematology 142. Which of the following red blood cell morphology abnormalities is associated hemoglobinopathies? A. Ovalocytes B. Target cells C. Echinocytes D. Acanthocytes 143 / 210 Category: Hematology 143. Which hemoglobin forms are incapable of oxygen transport ? A. Deoxyhemoglobin and carboxyhemoglobin B. Methemoglobin and deoxyhemoglobin C. Oxyhemoglobin and deoxyhemoglobin D. Carboxyhemoglobin and methemoglobin 144 / 210 Category: Hematology 144. What are the stages of erythrocyte maturation from the earliest recognizable stage ? A. Rubriblast, Prorubricyte, rubricyte, metarubricyte, reticulocyte B. Rubriblast, rubricyte, prorubricyte, metarubricyte, reticulocyte C. Rubriblast, rubricyte, metarubricyte, reticulocyte D. Rubriblast, metarubricyte, reticulocyte 145 / 210 Category: Hematology 145. Which of the following disorders is associated with left shift, toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score ? A. Basophilic stipplings B. Chronic myelogenous leukemia C. Neutrophilic leukemoid reaction (NLR) D. Acute myelogenous leukemia 146 / 210 Category: Hematology 146. Lymphocytic cell stains negative in which of the following stains? A. Myeloperoxidase (MPO) and Sudan black B B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS) C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains 147 / 210 Category: Hematology 147. Where is erythropoietin produced ? A. Brain B. Spleen C. Liver D. Kidney 148 / 210 Category: Hematology 148. Which malignant disorder is characterized by the presence of oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia and abnormal morphology associated with all cell lines ? A. Acute erythroleukemia B. Acute myelomonocytic leukemia C. Acute promyelocytic leukemia (APL) D. Myelodysplastic Syndromes (MDSs) 149 / 210 Category: Hematology 149. Which chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)? A. t(15;17) B. t(8;11) C. t(8;14) D. t(11;17) 150 / 210 Category: Hematology 150. Which stain is useful in the diagnosis of erythroleukemia (FAB M6) and acute lymphoblastic leukemia? A. Myeloperoxidase (MPO) B. Periodic acid-Schiff (PAS) C. Nonspecific esterase stains D. Sudan Black 151 / 210 Category: Hematology 151. Deficiency of intrinsic factors causes? A. Iron deficiency anemia B. Sideroblastic anemia C. Lead poisoning D. Pernicious anemia 152 / 210 Category: Hematology 152. Which erythrocyte metabolic pathway generates adenosine triphosphate (ATP) through glycolysis? A. Methemoglobin reductase B. Rapoport-Luebering C. Hexose monophosphate D. Embden-Meyerhof 153 / 210 Category: Hematology 153. Smudge cell is seen in which of the following malignancy? A. Chronic lymphocytic leukemia (CLL) B. Hairy cell leukemia (HCL) C. Acute lymphocytic leukemia (CLL) D. Chronic myelogenous leukemia (CML) 154 / 210 Category: Hematology 154. Which type of anemia will cause iron overload? A. Thalassemia B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 155 / 210 Category: Hematology 155. In what condition would an LAP score of 10 most likely be found? A. Bacterial septicemia B. Late pregnancy C. Polycythemia vera D. Chronic myelogenous leukemia 156 / 210 Category: Hematology 156. Which erythrocyte metabolic pathway generates 2,3-bisphosphoglycerate ? A. Embden-Meyerhof B. Hexose monophosphate C. Rapoport-Luebering D. Methemoglobin reductase 157 / 210 Category: Hematology 157. Which erythrocyte metabolic pathway generates NADPH ? A. Embden-Meyerhof B. Hexose monophosphate C. Rapoport-Luebering D. Methemoglobin reductase 158 / 210 Category: Hematology 158. Burkitt lymphoma is associated with which of the following virus? A. Polio Virus B. Rotavirus C. Coxcakie Virus D. Epstein Barr Virus 159 / 210 Category: Hematology 159. What does the term "anisocytosis" mean? A. Variations in size B. Variations in shape C. Variation of central palor D. Variations in color 160 / 210 Category: Hematology 160. What is an increase in the percentage of lymphocytes called? A. Absolute lymphopenia B. Absolute lymphocytosis C. Relative lymphocytosis D. Absolute polycythemia 161 / 210 Category: Hematology 161. What is the primary site for pre-B cell differentiation ? A. Liver B. Spleen C. Thymus D. Bone marrow 162 / 210 Category: Hematology 162. What is this abnormality called? A. Chediak Higash B. Alder Reily Anomaly C. Leukomoid Reaction D. Large neutrophils 163 / 210 Category: Hematology 163. Which of the following is associated with a "shift to the right" in the oxygen dissociation curve of hemoglobin ? A. Decreased oxygen release B. Increased pH, high 2,3-bisphosphoglycerate and increased body temperature C. Decreased pH, high 2, 3-bisphosphoglycerate and elevated temperature D. Decreased carbon release 164 / 210 Category: Hematology 164. What is a true increase in the number of lymphocytes called? A. Absolute lymphopenia B. Absolute lymphocytosis C. Relative lymphocytosis D. Absolute polycythemia 165 / 210 Category: Hematology 165. Which of the following characterizes iron deficiency anemia? A. Decreased serum iron, increased transferrin saturation, normal ferritin B. Increased serum iron, decreased transferrin saturation, decreased ferritin C. Decreased serum iron, decreased ferritin and Increased TIBC D. Increased serum transferrin, increased ferritin, and decreased Total iron binding capacity (TIBC) 166 / 210 Category: Hematology 166. Which neutrophil abnormality is associated with Vitamin B12 deficiency? A. Hyposegmented neutrophil B. Hypersegmented neutrophil C. Enlarged neutrophils D. Bilobed neutrophil 167 / 210 Category: Hematology 167. What is the expected result of a solubility test for patients with Hgb SS disease? A. Negative B. Positive 168 / 210 Category: Hematology 168. Which hemolytic anemia occurs most often in children following E. coli infection? A. Paroxysmal nocturnal hemoglobinuria (PNH) B. Hemolytic uremic syndrome (HUS) C. Microangiopathic hemolytic anemias (MAHAs) D. Thrombotic thrombocytopenic purpura (TTP) 169 / 210 Category: Hematology 169. Which neutrophil abnormality is caused by MYH9 gene mutation, and characterized by the presence of Dohle-like bodies, giant platelets and thrombocytopenia? A. Pelger Huet Anomaly B. May-Hegglin anomaly C. Chediak-Higashi syndrome D. Chronic granulomatous disease (CGD) 170 / 210 Category: Hematology 170. Which abnormal red blood cell is seen in abetalipoproteinemia? A. Spherocytes B. Acanthocytes C. Echinocytes D. Codocytes 171 / 210 Category: Hematology 171. Which of the following characterizes anemia of chronic inflammation? A. Serum iron Increased, transferrin decreased, and increased ferritin B. Serum iron decreased, transferrin decreased, and decreased ferritin C. Serum iron increased, Increased transferrin, and decreased ferritin D. Serum iron decreased, ferritin increased, and decreased Total Iron Binding Capacity(TIBC) 172 / 210 Category: Hematology 172. Which of the following is a true red cell aplasia? A. Diamond-Blackfan anemia B. Fanconi anemia C. Sideroblastic anemia D. Aplasia 173 / 210 Category: Hematology 173. Which hemoglobin migrates with Hgb S and Hgb G on alkaline hemoglobin electrophoresis? A. Hgb F B. Hgb C C. Hgb D D. Hgb SC 174 / 210 Category: Hematology 174. Which of the following is a lipid storage disorder caused by deficiency in sphingomyelinase, associated with foamy bone marrow appearance ? A. Niemann-Pick disease B. Gaucher disease C. Alder normally D. Chronic granulomatous disease (CGD) 175 / 210 Category: Hematology 175. Impaired DNA metabolism is characteristic of which type of anemia? A. Folic acid deficiency B. Iron deficiency anemia C. Sideroblastic anemia D. Lead poisoning 176 / 210 Category: Hematology 176. What red cell morphologic abnormality have unevenly pointed projections and associated with abetalipoproteinemia A. Spherocytes B. Echinocytes C. Dacrocytes D. Acanthocytes 177 / 210 Category: Hematology 177. What structure do methylene blue stain? A. DNA B. RNA C. Hemoglobin D. DNA and RNA 178 / 210 Category: Hematology 178. What is this cell? A. Macrophages B. Monocytes C. Plasma cell D. Reactive Lymphocytes 179 / 210 Category: Hematology 179. What is this cell? A. Hgb SS Crystals B. Hgb SC Crystals C. Hgb C Crystals D. Hgb E Crystals 180 / 210 Category: Hematology 180. What is this cell? A. Monocytes B. Eosinophils C. Lymphocytes D. Basophils 181 / 210 Category: Hematology 181. Pancytopenia is seen in which type of anemia? A. Iron deficiency anemia B. Sideroblastic anemia C. Aplastic anemia D. Anemia of chronic inflammation 182 / 210 Category: Hematology 182. Which gene mutation is implicated in Essential thrombocythemia (ET)? A. JAK2 oncogene B. t(8;11) C. t(8;14) D. BCR/ABL oncogene 183 / 210 Category: Hematology 183. Serum ferritin is an indirect measurement of A. Tissue iron B. Storage iron C. Hemoglobin iron D. Transferrin iron 184 / 210 Category: Hematology 184. What is this cell? A. Dacrocytes B. Reticulocyte C. Sickle Cells D. Elliptocytes 185 / 210 Category: Hematology 185. Which stain is used for reticulocyte count? A. Prussian blue B. Wright's stain C. Supravital stain D. New methylene Blue 186 / 210 Category: Hematology 186. What is the genetic translocation in FAB L3/Burkitt lymphoma? A. t(15;17) B. t(8;11) C. t(8;14); with a rearrangement of the MYC oncogene D. t(11;17) 187 / 210 Category: Hematology 187. What is the major storage form of iron? A. Transferrin B. Hemosiderin C. Ferritin D. Hemachromatin 188 / 210 Category: Hematology 188. Hgb C Disease/Hgb CC is caused by substitution of glutamic acid with.. A. Lysine B. Valine C. Leucine D. Glycine 189 / 210 Category: Hematology 189. Defective nuclear maturation commonly results in the production of red cells that are ? A. Normocytic B. Hypochromic C. Macrocytic D. Microcytic 190 / 210 Category: Hematology 190. What is this cell? A. Dacrocytes B. Reticulocyte C. Codocytes D. Elliptocytes 191 / 210 Category: Hematology 191. Total iron binding capacity (TIBC) measures A. Amount of transferrin B. Amount of iron that transferrin can bind C. Hepcidin D. Ferritin 192 / 210 Category: Hematology 192. Which malignant disorder is associated with left shift with myelocytes the predominate cell? A. Acute myelogeneous leukemia B. Chronic myelogenous leukemia C. Acute promyelocytic leukemia (APL); FAB M3 D. Acute megakaryocytic leukemia (AMegL; FAB M7) 193 / 210 Category: Hematology 193. What is this cell? A. Macrophages B. Hairy Cell Leukemia C. Plasma cell D. Lymphocytes 194 / 210 Category: Hematology 194. Calculate percent transferrin Serum iron is 22 μg/dL TIBC is 180 μg/dL A. 17% B. 25% C. 12% D. 15% Transferrin Saturation %= Serum iron x 100 / TIBC 22 X 100 / 180 195 / 210 Category: Hematology 195. Pappenheimer bodies are composed of ? A. Vitamin K B. RNA C. Iron granules D. DNA 196 / 210 Category: Hematology 196. What does Wright's stain consist of ? A. Methylene blue and cresyl green B. Methylene blue and neutral red C. Methylene blue and eosin D. Methylene blue and Giemsa stain 197 / 210 Category: Hematology 197. What is the process of blood cell formation called? A. Hemochromatosis B. Apotosis C. Hematopoiesis D. Mitosis 198 / 210 Category: Hematology 198. Which of the following stain is used in the diagnosis of Hairy cell leukemia? A. Periodic acid-Schiff (PAS) B. Nonspecific esterase stains C. Sudan Black D. Tartrate-resistant acid phosphatase stain (TRAP) 199 / 210 Category: Hematology 199. Which lymphoma has Reed-Sternberg cells? A. Hodgkin lymphoma B. Non-Hodgkin lymphoma C. Acute lymphocytic leukemia (CLL) D. Chronic myelogenous leukemia (CML) 200 / 210 Category: Hematology 200. What is this cell? A. Elliptocytes B. Dacrocytes C. Red blood cells D. Spherocytes 201 / 210 Category: Hematology 201. Which disorder occurs when glutamic acid is replaced by valine at position 6 on both beta chains.? A. Hgb E B. Hgb SC C. Sickle Cell Disease (Hgb SS) D. Hgb C 202 / 210 Category: Hematology 202. Decreased haptoglobin is indicative of A. Extravascular hemolysis B. Intravascular hemolysis C. Intramedullary hematopoiesis D. Intermedullary hematopoiesis 203 / 210 Category: Hematology 203. Identify the cell A. Microcytic normochromic red blood cells B. Microcytic hypochromic red blood cells C. Macrocytic red blood cells D. Normochromic red blood cells 204 / 210 Category: Hematology 204. Which stain is useful in the diagnosis of acute monocytic leukemia (FAB M5)? A. Myeloperoxidase (MPO) B. Periodic acid-Schiff (PAS) C. Nonspecific esterase stains D. Sudan Black 205 / 210 Category: Hematology 205. An aggressive form of cutaneous T-cell lymphoma is? A. Sezary syndrome B. Mycosis fungoides C. Reed-Sternberg syndrome D. Chronic myelogenous leukemia (CML) 206 / 210 Category: Hematology 206. What is the MCHC? Hemoglobin 14.1 g/dL RBC 4.12 x 10^12/L Hematocrit 41.3% A. 34.2g/dL B. 34.1g/dL C. 32.2g/dL D. 27.2g/dL 207 / 210 Category: Hematology 207. What is the MCH? Hemoglobin 11.1 g/dL RBC 3.65 x 10^12/L Hematocrit 32.5% A. 31pg B. 33 pg C. 30.9pg D. 30.4pg 208 / 210 Category: Hematology 208. Basophilia is associated with ? A. Type I hypersensitivity reactions B. Leukemoid reaction (NLR) C. Type I hypersensitivity reactions and chronic myelogenous leukemia D. Chronic myelogenous leukemia 209 / 210 Category: Hematology 209. Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)? A. t(15;17); PML/RARA oncogene B. t(8;11) C. t(8;14) D. t(11;17) 210 / 210 Category: Hematology 210. Which of the following is an acquired membrane defect in which the red cell membrane has increased sensitivity for complement binding? A. Pyruvate kinase (PK) deficiency B. G6PD (glucose-6-phosphate dehydrogenase) deficiency C. Hereditary spherocytosis D. Paroxysmal nocturnal hemoglobinuria (PNH) Your score is LinkedIn Facebook Twitter VKontakte 0% Restart quiz Send feedback Share this: Share on X (Opens in new window) X Share on Facebook (Opens in new window) Facebook Like this:Like Loading...