Hematology Test Bank

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Hematology Question Bank

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Category: Hematology

1. What are the three stages of hematopoiesis?

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2. Which of the following clinical finding is associated with Hgb SS disease?

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3. Blood loss caused by gastrointestinal bleeding is classified as

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4. Deficiency of intrinsic factors causes?

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5. Decrease in absolute number of neutrophils is called ?

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6. Pappenheimer bodies are composed of ?

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7. Which type of anemia will cause iron overload?

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8. Calculate percent transferrin 

Serum iron is 22 μg/dL

 TIBC is 180 μg/dL

 

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9. What is the MCV?

Hemoglobin 14.9 g/dL
RBC 4.84 x 10^12/L
Hematocrit 44.4%

 

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10. Which lymphoma has Reed-Sternberg cells?

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11. What does the term "poikilocytosis" mean?

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12. Which macrocytic anemia affects the Central Nervous System?

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13. A sudden loss of blood from traumatic injuries is..

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14. Antigen-independent lymphopoiesis occurs in 

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15. World Health Organization (WHO) defines acute leukemia as?

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16. Which gene mutation is implicated in polycythemia?

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17. In what condition would an LAP score of 10 most likely be found?

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18. What is an excessive accumulation of iron in body tissues called?

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19. Where is erythropoietin produced ?

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20. Senescent RBCs are phagocytized by macrophages in the liver or spleen and removed through 

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21. Which of the following test is used to measure bone marrow erythropoiesis?

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22. What is the MCH?

Hemoglobin 11.1 g/dL
RBC 3.65 x 10^12/L
Hematocrit 32.5%

 

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23. Which hemolytic anemia is caused due to a deficiency of the enzyme ADAMTS 13?

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24. Which of the following differentiates non-megaloblastic macrocytic anemias from megaloblastic anemias?

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25. Which of the following characterizes sideroblastic anemia?

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26. Which of the following red blood cell precursors is the last stage to undergo mitosis?

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27. What is the primary site of hematopoiesis in the fifth month of gestation?

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28. Which gene mutation is implicated in Essential thrombocythemia (ET)?

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29. What is the first type of blood cell produced by the developing embryo?

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30. Auer rods will stain positive in which of the following stains?

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31. Which stain is used for reticulocyte count ?

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32. Which of the following is associated with a "shift to the right" in the oxygen dissociation curve of hemoglobin ?

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33. Which stain is used for reticulocyte count?

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34. Microcytic, hypochromic red cells are most often associated with impaired

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35. Which of the following is a lipid storage disorder caused by deficiency in sphingomyelinase, associated with foamy bone marrow appearance ?

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36. What is the normal ratio of myeloid to erythroid precursors in the bone marrow (M:E ratio)?

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37. Which of the following characterizes iron deficiency anemia?

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38. What is this cell?

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39. Which term describes a decrease in all blood cell lines?

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40. Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

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41. What structure do methylene blue stain?

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42. Which neutrophil abnormality is caused by MYH9 gene mutation, and characterized by the presence of Dohle-like bodies, giant platelets and thrombocytopenia?

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43. What is the primary site of hematopoiesis in the third month of gestation?

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44. Which of the following stain is used in the diagnosis of Hairy cell leukemia?

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45. What is the pH of blood?

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46. What is this cell?

Question Image

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47. The majority of iron found in an adult is a constituent of

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48. Granulocytic cells will stain positive in which of the following stains?

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49. What is the genetic translocation in FAB L3/Burkitt lymphoma?

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50. An aggressive form of cutaneous T-cell lymphoma is?

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51. Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia?

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52. Which hemoglobin migrates with with hemoglobins A2, E, and O on alkaline hemoglobin electropheroseis?

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53. The most common cause of aplastic anemia is?

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54. Impaired DNA metabolism is characteristic of which type of anemia?

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55. What structures do methylene blue stain?

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56. Which disorder occurs when glutamic acid is replaced by valine at position 6 on both beta chains.?

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57. Defective hemoglobin synthesis due to a block in the protoporphyrin pathway will result in which type of anemia?

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58. What is the expected result of a solubility test for patients with Hgb SS disease?

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59. Which of the following disorders is associated with left shift, toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score ?

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60. What is the MCH?

Hemoglobin 14.1 g/dL
RBC 4.12 x 10^12/L
Hematocrit 41.3%

 

 

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61. Howell-Jolly bodies are composed of 

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62. Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

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63. Which of the following cell type will stain negative in Myeloperoxidase (MPO) stains?

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64. Which neutrophil abnormality is caused by mutation in Lamin B receptor and characterized by the presence of bilobed neutrophils ?

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65. What is this cell?

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66. This abnormality is caused by mutation in LYST gene, what is this cell?

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67.  Burkitt lymphoma is associated with which of the following virus?

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68. Which type of hemoglobin is produced in the mesoblastic phase?

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69. The presence of the chromosomal abnormality t(15;17) with disseminated intravascular coagulation (DIC) is diagnostic of?

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70. Which of the following characterizes anemia of chronic inflammation?

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71. Which of the following disorder is associated with left shift with toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score?

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72. Impaired DNA metabolism is characteristic of which type of anemia?

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73. Which type of anemia is associated with hypersegmented neutrophils?

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74.  Which cell type is predominant in acute myelogeneous leukemia?

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75. Which of the following anemia is associated with dwarfism and mental retardation?

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76.  Which malignant disorder is characterized by the presence of oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia and abnormal morphology associated with all cell lines ?

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77. Thalassemias are the result of a?

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78. Impaired release of storage iron due to increased hepcidin levels will result in ?

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79.   Which erythrocyte metabolic pathway generates 2,3-bisphosphoglycerate ?

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80. Which protein transports hemoglobin dimers resulting from intravascular hemolysis ? 

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81. Identify the cell

Question Image

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82. Which abnormal red blood cell is seen in abetalipoproteinemia?

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83. Which hemolytic anemia occurs most often in children following E. coli infection?

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84. What is the primary site for pre-B cell differentiation ?

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85. Hemoglobinopathies are inherited disorders caused by

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86. Impaired DNA metabolism is characteristic of which type of anemia?

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87. What is this cell?

Question Image

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88. In normocytic/normochromic anemia reticulocyte is

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89. Hemoglobin F consists of  ?

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90. Which of the following factors will result in an immediate increase in oxygen delivery to the tissues ? 

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91. What is the genetic translocation for FAB M2 (AML with maturation)?

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92. What is this cell?

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93. This rod is associated with acute promyelocytic leukemia(AML). Identify the cell?

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94. A 21-year-old woman complains to his physician of fatigue, dizziness, and craving for ice. Her results are as follows: 

Based on her laboratory result, what is the cause of anemia?

WBC 4.8 x 10^9/L 

RBC 3.75 x 10^12/L 

Hemoglobin 9.8 g/dL

Hematocrit 29%

MCV 77.3 fL

MCHC 33.8 g/dL

Serum iron and ferritin is decreased

Elevated total iron-binding capacity (TIBC) 

Blood smear shows microcytic hypochromic red blood cells

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95. Basophilia is associated with?

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96. What is the average lifespan of a normal red blood cell ?

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97. Which erythrocyte metabolic pathway generates NADPH ?

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98. What is this cell?

Question Image

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99. Antigen-dependent lymphopoiesis occurs in secondary lymphoid tissue located in 

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100. Which of the following conditions is most commonly associated with pica?

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101. An increased number of immature cell types in the peripheral blood is 

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102. Neutrophils with 5 or more lobes are called ?

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103. Which stain is used to enumerate reticulocytes ?

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104. Hemoglobin A2 consists of ?

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105. Which classification is based on cellular morphology and cytochemical stain results?

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106. Impaired DNA metabolism is characteristic of which type of anemia ?

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107. What is the process of blood cell formation called?

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108. What does the term "anisocytosis" mean?

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109. Which of the following is the most common cause of iron deficiency?

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110. Which of the following stain is used to visualize iron granules in RBCs ?

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111. What does Wright's stain consist of?

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112. What is a true increase in the number of lymphocytes called?

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113. Which of the following stain is used to visualize iron granules in RBCs?

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114. French-American-British (FAB) defines acute leukemia as?

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115. Which of the following is a true red cell aplasia?

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116. Which chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

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117. Diphyllobothrium latum is associated with the development of?

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118. Basophilia is associated with ?

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119. What is the MCHC?

Hemoglobin 14.1 g/dL
RBC 4.12 x 10^12/L
Hematocrit 41.3%

 

 

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120. What red cell morphologic abnormality have unevenly pointed projections and associated with abetalipoproteinemia

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121. What is the genetic translocation in chronic myelogenous leukemia (CML)?

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122. What is this cell?

Question Image

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123. What is the primary site of hematopoiesis in the first month of gestation?

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124. Defective nuclear maturation commonly results in the production of red cells that are ?

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125. Which of the following acquired hemolytic disorder causes intravascular hemolysis, presents with thrombocytopenia and schistocytes in peripheral blood smear?

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126. Which of the following red blood cell morphology abnormalities is associated hemoglobinopathies?

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127. What is the MCH?

Hemoglobin 14.9 g/dL
RBC 4.84 x 10^12/L
Hematocrit 44.4%

 

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128. What is the MCV?

Hemoglobin 11.1 g/dL
RBC 3.65 x 10^12/L
Hematocrit 32.5%

 

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129. Which of the following is the major transport protein of iron ?

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130. What is the structure of the hemoglobin molecule ? 

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131. Which inclusion is seen in G6PD (glucose-6-phosphate dehydrogenase) deficiency?

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132. Which of the following is a lipid storage disorder caused by deficiency in glucocerebrosidase

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133. Which of the following test is used to measure bone marrow erythropoiesis?

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134. What are the two primary lymphoid tissues ?

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135. What is an increase in the percentage of lymphocytes called?

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136. Total iron binding capacity (TIBC) measures 

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137. Which of the following inclusions is only visible with supravital stain?

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138. A 27-year-old woman complains to his physician of pain and fatigue. Her results are as follows: 

WBC 5.4 x 10^9/L 

RBC 3.9 x 10^12/L 

Hemoglobin 8.2 g/dL

Hematocrit 28%

MCV 72 fL

MCHC 29.3 g/dL

ESR increased

Serum iron and total iron-binding capacity (TIBC) both decreased

Serum ferritin slightly elevated. 

Presence of Prussian-blue-stainable iron in bone marrow was also noted.

Based her laboratory result, what is the cause of anemia?

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139. What hemoglobin is predominant at birth ?

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140. Which stain is useful in the diagnosis of acute monocytic leukemia (FAB M5)?

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141. What is the major storage form of iron?

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142. In what condition would an LAP score of 180 most likely be found?

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143. Which of the following is the most commonly used routine stain for blood smear?

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144. Which erythrocyte metabolic pathway generates adenosine triphosphate (ATP) through glycolysis?

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145. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia?

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146. A neutrophil disorder caused by mutations in the LYST gene and associated oculocutaneous albinism is ?

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147. Which type of anemia would you see ringed sideroblasts?

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148. What is the MCV?

Hemoglobin 14.1 g/dL
RBC 4.12 x 10^12/L
Hematocrit 41.3%

 

 

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149. Which leukemia is characterized by a proliferation of megakaryoblasts and positivity for CD41, CD42, and CD61 by flow cytometry?

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150. Hgb D Disease is caused by substitution of glutamic acid with.

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151. What is this cell?

Question Image

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152. Which of the following stains are used to differentiate blasts of acute myelogenous leukemias (AMLs) from acute lymphoblastic leukemia (ALLs)?

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153. Adult hemoglobin consists of ?

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154. Which cell type is predominant in acute lymphoblastic leukemia?

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155. Which classification for hematopoietic malignancy is the accepted standard for diagnosis?

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156. Serum ferritin is an indirect measurement of 

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157. What is a true increase in the number of lymphocytes called ?

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158. What is the primary site for pre-T cell differentiation?

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159. Which protein regulates iron homeostasis ?

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160. Which of the following is diagnostic of Multiple myeloma?

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161. Which neutrophil abnormality is associated with Vitamin B12 deficiency?

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162. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia ?

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163. What is an increase in the percentage of lymphocytes called ?

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164. What does Wright's stain consist of ?

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165. A block in the protoporphyrin pathway resulting in defective hemoglobin synthesis is characteristic of which type of anemia?

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166. What is this cell multi-lobed cells called?

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167. In Waldenstrom macroglobulinemia which immunoglobin is increasingly produced?

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168. Which gene mutation is associated with chronic myelogenous leukemia?

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169. What substance has a greater affinity for hemoglobin than oxygen ?

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170. What term describes a mature red blood cell that contains iron granules ?

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171. Which malignant disorder is associated with left shift with myelocytes the predominate cell?

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172. Smudge cell is seen in which of the following malignancy?

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173. Which stain is useful in the diagnosis of erythroleukemia (FAB M6) and acute lymphoblastic leukemia?

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174. Which hemoglobin migrates with Hgb S and Hgb G on alkaline hemoglobin electrophoresis?