Hematology Test Bank -

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Hematology Question Bank

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Category: Hematology

1. Which of the following characterizes iron deficiency anemia?

A. Decreased serum iron, increased transferrin saturation, normal ferritin

B. Increased serum iron, decreased transferrin saturation, decreased ferritin

C. Decreased serum iron, decreased ferritin and Increased TIBC

D. Increased serum transferrin, increased ferritin, and decreased Total iron binding capacity (TIBC)

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Category: Hematology

2. Diphyllobothrium latum is associated with the development of?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Lead poisoning

D. Vitamin B12 deficiency

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Category: Hematology

3. What is the MCH?


Hemoglobin	14.1 g/dL
RBC	4.12 x 10^12/L
Hematocrit	41.3%

A. 34.2pg

B. 29.2pg

C. 32.2pg

D. 27.2pg

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Category: Hematology

4. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia?

A. Low Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

B. High Leukocyte Alkaline Phosphatase (LAP) score in chronic myelogenous leukemia

C. High Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

D. Philadelphia chromosome, t (9; 22) score in leukemoid reaction

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Category: Hematology

5. Which of the following is a true red cell aplasia?

A. Diamond-Blackfan anemia

B. Fanconi anemia

C. Sideroblastic anemia

D. Aplasia

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Category: Hematology

6. Which hemoglobin migrates with with hemoglobins A2, E, and O on alkaline hemoglobin electropheroseis?

A. Hgb F

B. Hgb C

C. Hgb SC

D. Hgb E

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Category: Hematology

7. What is a true increase in the number of lymphocytes called ?

A. Absolute lymphocytosis

B. Absolute lymphopenia

C. Relative lymphocytosis

D. Absolute polycythemia

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Category: Hematology

8. Which type of anemia is associated with hypersegmented neutrophils?

A. Sideroblastic anemia

B. Megaloblastic anemia

C. Microcytic anemia

D. Thalassemia

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Category: Hematology

9. Defective hemoglobin synthesis due to a block in the protoporphyrin pathway will result in which type of anemia?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

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Category: Hematology

10. Which cell type is predominant in acute myelogeneous leukemia?

A. lymphoblasts

B. myeloblasts

C. lymphocytes

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Category: Hematology

11. Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia?

A. Chronic lymphocytic leukemia (CLL)

B. Hairy cell leukemia (HCL)

C. Acute lymphocytic leukemia (CLL)

D. Chronic myelogenous leukemia (CML)

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Category: Hematology

12. What does Wright's stain consist of ?

A. Methylene blue and cresyl green

B. Methylene blue and neutral red

C. Methylene blue and eosin

D. Methylene blue and Giemsa stain

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Category: Hematology

13. The most common cause of aplastic anemia is?

A. Idiopathic

B. Diamond-Blackfan anemia

C. Fanconi anemia

D. Sideroblastic anemia

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Category: Hematology

14. What is an increase in the percentage of lymphocytes called ?

A. Absolute lymphopenia

B. Relative lymphocytosis

C. Absolute lymphocytosis

D. Absolute polycythemia

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Category: Hematology

15. Pancytopenia is seen in which type of anemia?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Aplastic anemia

D. Anemia of chronic inflammation

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Category: Hematology

16. In what condition would an LAP score of 10 most likely be found?

A. Bacterial septicemia

B. Late pregnancy

C. Polycythemia vera

D. Chronic myelogenous leukemia

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Category: Hematology

17. Adult hemoglobin consists of ?

A. Hgb F contains two alpha- and four beta-globin chains

B. Hgb A contains four alpha- and two beta-globin chains

C. Hgb A contains two alpha- and two beta-globin chains

D. Hgb F contains three alpha- and four beta-globin chains

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Category: Hematology

18. Which of the following clinical finding is associated with Hgb SS disease?

A. Bone marrow erythroid hyperplasia

B. Decreased haptoglobin

C. Positive hemoglobin solubility

D. All of the above

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Category: Hematology

19. What is this cell?

A. Dacrocytes

B. Schistocytes

C. Echinocytes

D. Acanthocytes

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Category: Hematology

20. Smudge cell is seen in which of the following malignancy?

A. Chronic lymphocytic leukemia (CLL)

B. Hairy cell leukemia (HCL)

C. Acute lymphocytic leukemia (CLL)

D. Chronic myelogenous leukemia (CML)

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Category: Hematology

21. Senescent RBCs are phagocytized by macrophages in the liver or spleen and removed through

A. Extravascular hemolysis

B. Intravascular hemolysis

C. Necrosis

D. Cell degeneration

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Category: Hematology

22. What are the stages of granulocyte development ?

A. Myeloblast, Promyelocyte, Myelocyte, Metamyelocyte, band neutrophils

B. Myeloblast, Myelocyte, Promyelocyte, Metamyelocyte, band neutrophils

C. Myeloblast, Myelocyte, Metamyelocyte, Promyelocyte, band neutrophils

D. Myeloblast, Myelocyte, Metamyelocyte, band neutrophils

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Category: Hematology

23. Howell-Jolly bodies are composed of

A. Vitamin K

B. RNA

C. Iron granules

D. DNA

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Category: Hematology

24. What is this cell?

A. Macrophages

B. Monocytes

C. Plasma cell

D. Reactive Lymphocytes

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Category: Hematology

25. What does Wright's stain consist of?

A. Methylene blue and cresyl green

B. Methylene blue and eosin

C. Methylene blue and neutral red

D. Methylene blue and Giemsa stain

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Category: Hematology

26. What is this cell?

A. Dacrocytes

B. Reticulocyte

C. Sickle Cells

D. Elliptocytes

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Category: Hematology

27. Which of the following stain is used to visualize iron granules in RBCs ?

A. Wright's stain

B. Supravital stain

C. New methylene Blue

D. Prussian blue

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Category: Hematology

28. Antigen-independent lymphopoiesis occurs in

A. Liver and spleen

B. Spleen and kidney

C. Peyer's patches and spleen

D. Thymus and bone marrow

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Category: Hematology

29. In normocytic/normochromic anemia reticulocyte is

A. Increased

B. Decreased

C. Normal

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Category: Hematology

30. Burkitt lymphoma is associated with which of the following virus?

A. Polio Virus

B. Rotavirus

C. Coxcakie Virus

D. Epstein Barr Virus

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Category: Hematology

31. Which of the following inclusions is only visible with supravital stain?

A. Dohle bodies

B. Pappenheimer bodies

C. Basophilic stippling

D. Heinz bodies

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Category: Hematology

32. In Waldenstrom macroglobulinemia which immunoglobin is increasingly produced?

A. IgM

B. IgG

C. IgA

D. IgS

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Category: Hematology

33. What is the pH of blood?

A. 7.25-7.45

B. 7.30-7.45

C. 7.32-7.49

D. 7.35-7.45

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Category: Hematology

34. Which cell transports oxygen and removes metabolic waste from the body ?

A. White blood cells

B. Platelets

C. Red blood cells

D. Plasma

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Category: Hematology

35. What is this cell?

A. Hgb SS Crystals

B. Hgb SC Crystals

C. Hgb C Crystals

D. Hgb E Crystals

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Category: Hematology

36. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia ?

A. Low Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

B. High Leukocyte Alkaline Phosphatase (LAP) score in chronic myelogenous leukemia

C. High Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

D. Philadelphia chromosome, t (9; 22) score in leukemoid reaction

37 / 210

Category: Hematology

37. What is the MCV?


Hemoglobin	11.1 g/dL
RBC	3.65 x 10^12/L
Hematocrit	32.5%

A. 84fL

B. 79fL

C. 89fL

D. 92fL

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Category: Hematology

38. Which of the following stain is used in the diagnosis of Hairy cell leukemia?

A. Periodic acid-Schiff (PAS)

B. Nonspecific esterase stains

C. Sudan Black

D. Tartrate-resistant acid phosphatase stain (TRAP)

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Category: Hematology

39. What structures do methylene blue stain?

A. DNA

B. RNA

C. Hemoglobin

D. DNA and RNA

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Category: Hematology

40. Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

A. Reed-Sternberg cells

B. Mycosis fungoides

C. Sezary syndrome

D. Smudge cells

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Category: Hematology

41. A 27-year-old woman complains to his physician of pain and fatigue. Her results are as follows:

WBC 5.4 x 10^9/L

RBC 3.9 x 10^12/L

Hemoglobin 8.2 g/dL

Hematocrit 28%

MCV 72 fL

MCHC 29.3 g/dL

ESR increased

Serum iron and total iron-binding capacity (TIBC) both decreased

Serum ferritin slightly elevated.

Presence of Prussian-blue-stainable iron in bone marrow was also noted.

Based her laboratory result, what is the cause of anemia?

A. Sideroblastic anemia

B. Anemia of Chronic Inflammation

C. Iron-deficiency anemia

D. Megaloblastic anemia

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Category: Hematology

42. Which of the following is the most common cause of iron deficiency?

A. Bleeding

B. Increased need

C. Inadequate diet

D. Pregnancy

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Category: Hematology

43. What is the MCV?


Hemoglobin	14.9 g/dL
RBC	4.84 x 10^12/L
Hematocrit	44.4%

A. 104fL

B. 79fL

C. 91.7fl

D. 99fL

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Category: Hematology

44. Which gene mutation is implicated in polycythemia?

A. JAK2 oncogene

B. t(8;11)

C. BCR/ABL oncogene

D. t(11;17)

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Category: Hematology

45. Which stain is useful in the diagnosis of erythroleukemia (FAB M6) and acute lymphoblastic leukemia?

A. Myeloperoxidase (MPO)

B. Periodic acid-Schiff (PAS)

C. Nonspecific esterase stains

D. Sudan Black

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Category: Hematology

46. What is the MCHC?


Hemoglobin	14.1 g/dL
RBC	4.12 x 10^12/L
Hematocrit	41.3%

A. 34.2g/dL

B. 34.1g/dL

C. 32.2g/dL

D. 27.2g/dL

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Category: Hematology

47. Which of the following stains are used to differentiate blasts of acute myelogenous leukemias (AMLs) from acute lymphoblastic leukemia (ALLs)?

A. Myeloperoxidase (MPO) and Sudan black B

B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS)

C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains

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Category: Hematology

48. A neutrophil disorder caused by mutations in the LYST gene and associated oculocutaneous albinism is ?

A. Pelger Huet Anomaly

B. Chediak-Higashi syndrome

C. May-Hegglin anomaly

D. Chronic granulomatous disease (CGD)

49 / 210

Category: Hematology

49. What is the MCV?


Hemoglobin	14.1 g/dL
RBC	4.12 x 10^12/L
Hematocrit	41.3%

A. 104fL

B. 79fL

C. 100.2fL

D. 99fL

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Category: Hematology

50. A block in the protoporphyrin pathway resulting in defective hemoglobin synthesis is characteristic of which type of anemia?

A. Thalassemia

B. Porphyrias

C. Iron-deficiency anemia

D. Megaloblastic anemia

51 / 210

Category: Hematology

51. An aggressive form of cutaneous T-cell lymphoma is?

A. Sezary syndrome

B. Mycosis fungoides

C. Reed-Sternberg syndrome

D. Chronic myelogenous leukemia (CML)

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Category: Hematology

52. Which of the following disorders is associated with left shift, toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score ?

A. Basophilic stipplings

B. Chronic myelogenous leukemia

C. Neutrophilic leukemoid reaction (NLR)

D. Acute myelogenous leukemia

53 / 210

Category: Hematology

53. Impaired DNA metabolism is characteristic of which type of anemia?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Lead poisoning

D. Vitamin B12 deficiency

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Category: Hematology

54. What is the genetic translocation in chronic myelogenous leukemia (CML)?

A. t(15;17)

B. t(9;22)

C. t(8;14); with a rearrangement of the MYC oncogene

D. t(11;17)

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Category: Hematology

55. Which of the following differentiates non-megaloblastic macrocytic anemias from megaloblastic anemias?

A. Oval erythrocytes in non-megaloblastic macrocytic

B. Round erythrocytes in megaloblastic anemias

C. Hypersegmented neutrophil in non-megaloblastic macrocytic

D. Round erythrocytes in non-megaloblastic macrocytic

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Category: Hematology

56. Chronic myeloproliferative disorders terminate in?

A. Acute leukemia

B. Chronic leukemia

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Category: Hematology

57. What is this cell?

A. Basophilic stipplings

B. Reticulocyte

C. Washed red blood cells

D. Artifact

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Category: Hematology

58. Which malignant disorder is characterized by the presence of oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia and abnormal morphology associated with all cell lines ?

A. Acute erythroleukemia

B. Acute myelomonocytic leukemia

C. Acute promyelocytic leukemia (APL)

D. Myelodysplastic Syndromes (MDSs)

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Category: Hematology

59. Which of the following is the most commonly used routine stain for blood smear ?

A. Prussian blue

B. Supravital stain

C. Wright's stain

D. New methylene Blue

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Category: Hematology

60. Which leukemia is characterized by a proliferation of megakaryoblasts and positivity for CD41, CD42, and CD61 by flow cytometry?

A. Acute erythroleukemia; FAB M6

B. Acute myelomonocytic leukemia ;AMML; FAB M4

C. Acute promyelocytic leukemia (APL); FAB M3

D. Acute megakaryocytic leukemia (AMegL; FAB M7)

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Category: Hematology

61. Which of the following conditions is most commonly associated with pica?

A. Anemia of chronic inflammation

B. Alpha thalassemia

C. Iron deficiency

D. Lead poisoning

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Category: Hematology

62. What is the MCH?


Hemoglobin	14.9 g/dL
RBC	4.84 x 10^12/L
Hematocrit	44.4%

A. 30.8pg

B. 34pg

C. 36pg

D. 29pg

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Category: Hematology

63. Which of the following red blood cell precursors is the last stage to undergo mitosis?

A. Band neutrophils

B. Promyelocyte

C. Myelocyte

D. Segmented neutrophils

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Category: Hematology

64. Which classification is based on cellular morphology and cytochemical stain results?

A. French-American-British (FAB)

B. World Health Organization (WHO)

C. Cancer Association Method

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Category: Hematology

65. Which neutrophil abnormality is caused by mutation in Lamin B receptor and characterized by the presence of bilobed neutrophils ?

A. Pelger Huet Anomaly

B. Chediak-Higashi syndrome

C. May-Hegglin anomaly

D. Chronic granulomatous disease (CGD)

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Category: Hematology

66. Which stain is used for reticulocyte count ?

A. Wright's stain

B. Supravital stain

C. New methylene Blue

D. Prussian blue

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Category: Hematology

67. Which of the following is not classified as a myeloproliferative disorder?

A. Polycythemia vera

B. Essential thrombocythemia

C. Seizary Syndrome

D. Chronic myelogenous leukemia

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Category: Hematology

68. What is this cell?

A. Dacrocytes

B. Reticulocyte

C. Target cells

D. Elliptocytes

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Category: Hematology

69. Which protein regulates iron homeostasis ?

A. Hemosiderin

B. Transferrin

C. Hepcidin

D. Hemopexin

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Category: Hematology

70. What is the oxidation state of iron in Hemoglobin ?

A. Oxide state

B. Ferrous state

C. Peroxide state

D. Ferric state

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Category: Hematology

71. Which neutrophil abnormality is associated with Vitamin B12 deficiency?

A. Hyposegmented neutrophil

B. Hypersegmented neutrophil

C. Enlarged neutrophils

D. Bilobed neutrophil

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Category: Hematology

72. A cutaneous lymphoma that causes skin itching and ulcerative tumor are called?

A. Mycosis fungoides

B. Reed-Sternberg syndrome

C. Waldenstrom macroglobulinemia

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Category: Hematology

73. Which of the following red blood cell morphology abnormalities is associated hemoglobinopathies?

A. Ovalocytes

B. Target cells

C. Echinocytes

D. Acanthocytes

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Category: Hematology

74. Which type of anemia would you see ringed sideroblasts?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

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Category: Hematology

75. Where is erythropoietin produced ?

A. Brain

B. Spleen

C. Liver

D. Kidney

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Category: Hematology

76. What is the average lifespan of a normal red blood cell ?

A. 90 days

B. 180 days

C. 120 days

D. 60 days

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Category: Hematology

77. What substance has a greater affinity for hemoglobin than oxygen ?

A. Carbon

B. Carbon dioxide

C. Carbonmonoxide

D. Oxide

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Category: Hematology

78. Which gene mutation is implicated in Essential thrombocythemia (ET)?

A. JAK2 oncogene

B. t(8;11)

C. t(8;14)

D. BCR/ABL oncogene

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Category: Hematology

79. World Health Organization (WHO) defines acute leukemia as?

A. >20% bone marrow blasts.

B. >30% bone marrow blasts.

C. >70% bone marrow blasts.

D. >50% bone marrow blasts.

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Category: Hematology

80. What is the first type of blood cell produced by the developing embryo?

A. Thrombocyte

B. Granulocyte

C. Lymphocytes

D. Erythrocytes

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Category: Hematology

81. Which erythrocyte metabolic pathway generates NADPH ?

A. Embden-Meyerhof

B. Hexose monophosphate

C. Rapoport-Luebering

D. Methemoglobin reductase

82 / 210

Category: Hematology

82. What is a true increase in the number of lymphocytes called?

A. Absolute lymphopenia

B. Absolute lymphocytosis

C. Relative lymphocytosis

D. Absolute polycythemia

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Category: Hematology

83. Microcytic, hypochromic red cells are most often associated with impaired

A. DNA synthesis

B. Hemoglobin synthesis

C. RNA metabolism

D. Enzyme metabolism

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Category: Hematology

84. What is the MCHC?


Hemoglobin	11.1 g/dL
RBC	3.65 x 10^12/L
Hematocrit	32.5%

A. 32.2g/dL

B. 24.2g/dL

C. 34.2g/dL

D. 36.2g/dL

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Category: Hematology

85. Which of the following characterizes anemia of chronic inflammation?

A. Serum iron Increased, transferrin decreased, and increased ferritin

B. Serum iron decreased, transferrin decreased, and decreased ferritin

C. Serum iron increased, Increased transferrin, and decreased ferritin

D. Serum iron decreased, ferritin increased, and decreased Total Iron Binding Capacity(TIBC)

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Category: Hematology

86. Antigen-dependent lymphopoiesis occurs in secondary lymphoid tissue located in

A. Liver and spleen

B. Spleen and kidney

C. Peyer's patches and spleen

D. Thymus and bone marrow

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Category: Hematology

87. Hemoglobinopathies are inherited disorders caused by

A. Amino acid substitutions

B. Block in NADPH

C. Abnormal Hemoglobin structure

D. Peptide mutation

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Category: Hematology

88. Which protein transports hemoglobin dimers resulting from intravascular hemolysis ?

A. Hemopexin

B. Albumin

C. Haptoglobin

D. Hemosiderin

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Category: Hematology

89. Total iron binding capacity (TIBC) measures

A. Amount of transferrin

B. Amount of iron that transferrin can bind

C. Hepcidin

D. Ferritin

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Category: Hematology

90. Decreased haptoglobin is indicative of

A. Extravascular hemolysis

B. Intravascular hemolysis

C. Intramedullary hematopoiesis

D. Intermedullary hematopoiesis

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Category: Hematology

91. What is the genetic translocation in FAB L3/Burkitt lymphoma?

A. t(15;17)

B. t(8;11)

C. t(8;14); with a rearrangement of the MYC oncogene

D. t(11;17)

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Category: Hematology

92. What is this cell?

A. Dacrocytes

B. Reticulocyte

C. Codocytes

D. Elliptocytes

93 / 210

Category: Hematology

93. What is the MCH?


Hemoglobin	11.1 g/dL
RBC	3.65 x 10^12/L
Hematocrit	32.5%

A. 31pg

B. 33 pg

C. 30.9pg

D. 30.4pg

94 / 210

Category: Hematology

94. French-American-British (FAB) defines acute leukemia as?

A. >20% bone marrow blasts.

B. >30% bone marrow blasts.

C. >70% bone marrow blasts.

D. >50% bone marrow blasts.

95 / 210

Category: Hematology

95. Which of the following is the most commonly used routine stain for blood smear?

A. Prussian blue

B. Wright's stain

C. Supravital stain

D. New methylene Blue

96 / 210

Category: Hematology

96. Impaired DNA metabolism is characteristic of which type of anemia?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

97 / 210

Category: Hematology

97. What is this cell?

A. Monocytes

B. Eosinophils

C. Lymphocytes

D. Basophils

98 / 210

Category: Hematology

98. Which inclusion is seen in G6PD (glucose-6-phosphate dehydrogenase) deficiency?

A. Heinz bodies

B. Ringed sideroblasts

C. Howell jolly

D. Pappenheimer bodies

99 / 210

Category: Hematology

99. The presence of the chromosomal abnormality t(15;17) with disseminated intravascular coagulation (DIC) is diagnostic of?

A. Acute myeloblastic leukemia without maturation (FAB type Ml)

B. Acute myeloblastic leukemia with maturation (FAB type M2)

C. Acute promyelocytic leukemia (FAB type M3)

D. Acute myelomonocytic leukemia (FAB type M4)

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Category: Hematology

100. What red cell morphologic abnormality has evenly spaced round projections and is associated with pyruvate kinase deficiency

A. Spherocytes

B. Echinocytes

C. Dacrocytes

D. Acanthocytes

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Category: Hematology

101. Which test is used to differentiate chronic myelogenous leukemia (CML) from a neutrophilic leukemoid reaction (NLR)?

A. Periodic acid-Schiff (PAS)

B. Nonspecific esterase stains

C. Sudan Black

D. Leukocyte alkaline phosphatase (LAP)

102 / 210

Category: Hematology

102. What is the primary site of hematopoiesis in the first month of gestation?

A. Spleen

B. Marrow of long bones

C. Liver

D. Yolk sac

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Category: Hematology

103. Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

A. t(15;17); PML/RARA oncogene

B. t(8;11)

C. t(8;14)

D. t(11;17)

104 / 210

Category: Hematology

104. Increased LAP score is seen in?

A. Chronic myelogenous leukemia (CML)

B. Paroxysmal nocturnal hemoglobinuria

C. Neutrophilic leukemoid reaction

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Category: Hematology

105. Which of the following test is used to measure bone marrow erythropoiesis?

A. Hams Sugar test

B. Reticulocyte count

C. Erythrocyte Sedimentation Rate

D. Cell count

106 / 210

Category: Hematology

106. What are the stages of erythrocyte maturation from the earliest recognizable stage?

A. Pronormoblast, normoblast, Polychromatophilic normoblast Orthochromic normoblast, Reticulocyte

B. Pronormoblast, Basophilic normoblast, Polychromatophilic normoblast normoblast, Reticulocyte

C. Pronormoblast, Basophilic normoblast, Polychromatophilic normoblast, Orthochromic normoblast, Reticulocyte

D. Rubriblast, metarubricyte, reticulocyte, Basophilic normoblast

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Category: Hematology

107. Pappenheimer bodies are composed of ?

A. Vitamin K

B. RNA

C. Iron granules

D. DNA

108 / 210

Category: Hematology

108. Which of the following is a lipid storage disorder caused by deficiency in sphingomyelinase, associated with foamy bone marrow appearance ?

A. Niemann-Pick disease

B. Gaucher disease

C. Alder normally

D. Chronic granulomatous disease (CGD)

109 / 210

Category: Hematology

109. Which of the following cell markers are seen in B cell malignancy?

A. CD19, and CD20 positive

B. CD2, and CD4 positive

C. CD2, CD19, and CD20 positive

D. CD4, CD19, and CD20 positive

110 / 210

Category: Hematology

110. Which hemoglobin migrates with hemoglobins A2, C, and O on alkaline hemoglobin electropheroseis?

A. Hgb F

B. Hgb C

C. Hgb SC

D. Hgb E

111 / 210

Category: Hematology

111. Thalassemias are the result of a?

A. Structural defect in the globin portion of hemoglobin

B. Quantitative defect in globin-chain synthesis

C. Qualitative defect in globin-chain structure

D. Qualitative defect in heme structure

112 / 210

Category: Hematology

112. Hgb D Disease is caused by substitution of glutamic acid with.

A. Lysine

B. Valine

C. Leucine

D. Glycine

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Category: Hematology

113. Which of the following anemia is associated with dwarfism and mental retardation?

A. Diamond-Blackfan anemia

B. Fanconi anemia

C. Sideroblastic anemia

D. Aplasia

114 / 210

Category: Hematology

114. What does the term "anisocytosis" mean?

A. Variations in size

B. Variations in shape

C. Variation of central palor

D. Variations in color

115 / 210

Category: Hematology

115. Which erythrocyte metabolic pathway generates adenosine triphosphate (ATP) through glycolysis?

A. Methemoglobin reductase

B. Rapoport-Luebering

C. Hexose monophosphate

D. Embden-Meyerhof

116 / 210

Category: Hematology

116. A sudden loss of blood from traumatic injuries is..

A. Chronic blood loss

B. Reticulocytosis

C. Acute blood loss

117 / 210

Category: Hematology

117. Which macrocytic anemia affects the Central Nervous System?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Folate deficiency

D. Vitamin B12 deficiency

118 / 210

Category: Hematology

118. Which of the following stains is used in distinguishing acute leukemias of myeloid origin from the monocytic origin?

A. Myeloperoxidase (MPO)

B. Periodic acid-Schiff (PAS)

C. Nonspecific esterase stains

119 / 210

Category: Hematology

119. Hemoglobin F consists of ?

A. Two alpha- and two beta-globin chains

B. Two alpha- and two gamma-globin chains

C. Two alpha- and two delta-globin chains

D. Four alpha- and two beta-globin chains

120 / 210

Category: Hematology

120. Which chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

A. t(15;17)

B. t(8;11)

C. t(8;14)

D. t(11;17)

121 / 210

Category: Hematology

121. An increased number of immature cell types in the peripheral blood is

A. Cell apoptosis

B. Cell degeneration

C. Right shift

D. Left shift

122 / 210

Category: Hematology

122. Which cell type is predominant in acute lymphoblastic leukemia?

A. lymphoblasts

B. myeloblasts

C. granulocytes

123 / 210

Category: Hematology

123. What are the three stages of hematopoiesis?

A. Meroblastic phase, hepatic phase, and medullary phase

B. Mesoblastic phase, primitive phase, and medullary phase

C. Primitive phase, definitive phase and hepatic phase

D. Mesoblastic phase, hepatic phase, and medullary phase

124 / 210

Category: Hematology

124. Impaired DNA metabolism is characteristic of which type of anemia?

A. Folic acid deficiency

B. Iron deficiency anemia

C. Sideroblastic anemia

D. Lead poisoning

125 / 210

Category: Hematology

125. What is this abnormality called?

A. Chediak Higash

B. Alder Reily Anomaly

C. Leukomoid Reaction

D. Large neutrophils

126 / 210

Category: Hematology

126. Which of the following is diagnostic of Multiple myeloma?

A. "M"-spike in the gamma-globulin region in serum electrophoresis

B. Bence Jones proteins in the urine

C. Excessive production IgM (macroglobulin)

D. production of excessive IgG (macroglobulin)

E. A ,B and D

127 / 210

Category: Hematology

127. Impaired DNA metabolism is characteristic of which type of anemia ?

A. Thalassemia

B. Sideroblastic anemia

C. Megaloblastic anemia

D. Iron-deficiency anemia

128 / 210

Category: Hematology

128. Which stain is useful in the diagnosis of acute monocytic leukemia (FAB M5)?

A. Myeloperoxidase (MPO)

B. Periodic acid-Schiff (PAS)

C. Nonspecific esterase stains

D. Sudan Black

CD13, CD33 positive (myeloid) and CD14 positive (monocytes)

129 / 210

Category: Hematology

129. Which of the following cell markers is positive in acute myelomonocytic leukemia (AMML; FAB M4)?

A. CD13, CD15, and CD33

B. CD13, CD33 positive and CD14 positive

C. CD45 and CD71

130 / 210

Category: Hematology

130. What hemoglobin is predominant at birth ?

A. Portland

B. Hgb F

C. Gower I

D. Gower II

131 / 210

Category: Hematology

131. Which of the following test is used to measure bone marrow erythropoiesis?

A. Hams Sugar test

B. Erythrocyte Sedimentation Rate

C. Reticulocyte count

D. Cell count

132 / 210

Category: Hematology

132. A 21-year-old woman complains to his physician of fatigue, dizziness, and craving for ice. Her results are as follows:

Based on her laboratory result, what is the cause of anemia?

WBC 4.8 x 10^9/L

RBC 3.75 x 10^12/L

Hemoglobin 9.8 g/dL

Hematocrit 29%

MCV 77.3 fL

MCHC 33.8 g/dL

Serum iron and ferritin is decreased

Elevated total iron-binding capacity (TIBC)

Blood smear shows microcytic hypochromic red blood cells

A. Anemia of Chronic Inflammation

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

133 / 210

Category: Hematology

133. Programmed cell death is called ?

A. Cell biopsy

B. Necrosis

C. Gangrene

D. Apoptosis

134 / 210

Category: Hematology

134. Identify the cell

A. Microcytic normochromic red blood cells

B. Microcytic hypochromic red blood cells

C. Macrocytic red blood cells

D. Normochromic red blood cells

135 / 210

Category: Hematology

135. In what condition would an LAP score of 180 most likely be found?

A. Bacterial septicemia

B. paroxysmal nocturnal hemoglobinuria

C. Polycythemia vera

D. Polycythemia vera and Bacterial septicemia

136 / 210

Category: Hematology

136. Which abnormal red blood cell is seen in abetalipoproteinemia?

A. Spherocytes

B. Acanthocytes

C. Echinocytes

D. Codocytes

137 / 210

Category: Hematology

137. Which hemolytic anemia is caused due to a deficiency of the enzyme ADAMTS 13?

A. Paroxysmal nocturnal hemoglobinuria (PNH)

B. Hemolytic uremic syndrome (HUS)

C. Microangiopathic hemolytic anemias (MAHAs)

D. Thrombotic thrombocytopenic purpura (TTP)uremic syndrome (HUS)

138 / 210

Category: Hematology

138. What is the major storage form of iron?

A. Transferrin

B. Hemosiderin

C. Ferritin

D. Hemachromatin

139 / 210

Category: Hematology

139. Which erythrocyte metabolic pathway generates 2,3-bisphosphoglycerate ?

A. Embden-Meyerhof

B. Hexose monophosphate

C. Rapoport-Luebering

D. Methemoglobin reductase

140 / 210

Category: Hematology

140. Which disorder occurs when glutamic acid is replaced by valine at position 6 on both beta chains.?

A. Hgb E

B. Hgb SC

C. Sickle Cell Disease (Hgb SS)

D. Hgb C

141 / 210

Category: Hematology

141. The majority of iron found in an adult is a constituent of

A. Haptoglobin

B. Myoglobin

C. Hemoglobin

D. Propyria

142 / 210

Category: Hematology

142. Which of the following characterizes sideroblastic anemia?

A. Serum iron decreased, transferrin decreased

B. Serum iron decreased, transferrin increased

C. Serum iron normal, transferrin normal

D. TIBC decreased, increased ferritin and serum iron

143 / 210

Category: Hematology

143. Lymphocytic cell stains negative in which of the following stains?

A. Myeloperoxidase (MPO) and Sudan black B

B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS)

C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains

144 / 210

Category: Hematology

144. Granulocytic cells will stain positive in which of the following stains?

A. Myeloperoxidase (MPO), Sudan black B, and Specific esterase stain

B. Myeloperoxidase (MPO), Periodic acid-Schiff (PAS), and non- specific esterase stain

C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains

145 / 210

Category: Hematology

145. What is this cell?

A. Macrophages

B. Monocytes

C. Plasma cell

D. Reactive Lymphocytes

146 / 210

Category: Hematology

146. What is this cell?

A. Elliptocytes

B. Dacrocytes

C. Red blood cells

D. Spherocytes

147 / 210

Category: Hematology

147. Which of the following is the major transport protein of iron ?

A. Transferrin

B. Ferritin

C. Hemosiderin

D. Haptoglobin

148 / 210

Category: Hematology

148. Hgb C Disease/Hgb CC is caused by substitution of glutamic acid with..

A. Lysine

B. Valine

C. Leucine

D. Glycine

149 / 210

Category: Hematology

149. Neutrophils with 5 or more lobes are called ?

A. Multisegmented neutrophils

B. Hypersegmented neutrophils

C. Hyposegmented neutrophils

D. Monosegmented neutrophils

150 / 210

Category: Hematology

150. Decrease in absolute number of neutrophils is called ?

A. Eosinophilia

B. Leukopenia

C. Neutropenia

D. Leukocytosis

151 / 210

Category: Hematology

151. What term describes a mature red blood cell that contains iron granules ?

A. Basophillic stippling

B. Siderocyte

C. Howell Jolly

D. Ringed sideroblast

152 / 210

Category: Hematology

152. Which stain is used for reticulocyte count?

A. Prussian blue

B. Wright's stain

C. Supravital stain

D. New methylene Blue

153 / 210

Category: Hematology

153. Calculate percent transferrin

Serum iron is 22 μg/dL

TIBC is 180 μg/dL

A. 17%

B. 25%

C. 12%

D. 15%

154 / 210

Category: Hematology

154. Which term describes a decrease in all blood cell lines?

A. Pancytopenia

B. Cellopenia

C. Reticulocytosis

D. Nucleopenia

155 / 210

Category: Hematology

155. Which hemolytic anemia occurs most often in children following E. coli infection?

A. Paroxysmal nocturnal hemoglobinuria (PNH)

B. Hemolytic uremic syndrome (HUS)

C. Microangiopathic hemolytic anemias (MAHAs)

D. Thrombotic thrombocytopenic purpura (TTP)

156 / 210

Category: Hematology

156. Which test is used to differentiate Warm autoimmune hemolytic anemia (WAIHA) from hereditary spherocytosis?

A. MCHC may be >37 g/dL

B. Increased osmotic fragility

C. Increased Bilirubin

D. Positive direct antiglobulin test (DAT)

157 / 210

Category: Hematology

157. Serum ferritin is an indirect measurement of

A. Tissue iron

B. Storage iron

C. Hemoglobin iron

D. Transferrin iron

158 / 210

Category: Hematology

158. Which hemoglobin migrates with Hgb S and Hgb G on alkaline hemoglobin electrophoresis?

A. Hgb F

B. Hgb C

C. Hgb D

D. Hgb SC

159 / 210

Category: Hematology

159. Which of the following acquired hemolytic disorder causes intravascular hemolysis, presents with thrombocytopenia and schistocytes in peripheral blood smear?

A. Microangiopathic hemolytic anemias (MAHAs)

B. Paroxysmal nocturnal hemoglobinuria (PNH)

C. Hemolytic uremic syndrome (HUS)

D. Thrombotic thrombocytopenic purpura (TTP)

E. All of the above

160 / 210

Category: Hematology

160. Which of the following cell type will stain negative in Myeloperoxidase (MPO) stains?

A. Granulocytic cells

B. Auer rods stain

C. Lymphocytic cells

161 / 210

Category: Hematology

161. Hemoglobin A2 consists of ?

A. Two alpha- and two beta-globin chains

B. Two alpha- and four beta-globin chains

C. Two alpha- and two delta-globin chains

D. Four alpha- and two beta-globin chains

162 / 210

Category: Hematology

162. What is this cell?

A. Macrophages

B. Hairy Cell Leukemia

C. Plasma cell

D. Lymphocytes

163 / 210

Category: Hematology

163. Which neutrophil abnormality is caused by MYH9 gene mutation, and characterized by the presence of Dohle-like bodies, giant platelets and thrombocytopenia?

A. Pelger Huet Anomaly

B. May-Hegglin anomaly

C. Chediak-Higashi syndrome

D. Chronic granulomatous disease (CGD)

164 / 210

Category: Hematology

164. Which lymphoma has Reed-Sternberg cells?

A. Hodgkin lymphoma

B. Non-Hodgkin lymphoma

C. Acute lymphocytic leukemia (CLL)

D. Chronic myelogenous leukemia (CML)

165 / 210

Category: Hematology

165. Which of the following is an acquired membrane defect in which the red cell membrane has increased sensitivity for complement binding?

A. Pyruvate kinase (PK) deficiency

B. G6PD (glucose-6-phosphate dehydrogenase) deficiency

C. Hereditary spherocytosis

D. Paroxysmal nocturnal hemoglobinuria (PNH)

166 / 210

Category: Hematology

166. What is the primary site for pre-T cell differentiation?

A. Liver

B. Spleen

C. Thymus

D. Bone marrow

167 / 210

Category: Hematology

167. Which classification for hematopoietic malignancy is the accepted standard for diagnosis?

A. French-American-British (FAB)

B. World Health Organization (WHO)

C. Cancer Association Method

168 / 210

Category: Hematology

168. Defective nuclear maturation commonly results in the production of red cells that are ?

A. Normocytic

B. Hypochromic

C. Macrocytic

D. Microcytic

169 / 210

Category: Hematology

169. What is an increase in the percentage of lymphocytes called?

A. Absolute lymphopenia

B. Absolute lymphocytosis

C. Relative lymphocytosis

D. Absolute polycythemia

170 / 210

Category: Hematology

170. Blood loss caused by gastrointestinal bleeding is classified as

A. Chronic blood loss

B. Reticulocytosis

C. Acute blood loss

171 / 210

Category: Hematology

171. What is the genetic translocation for FAB M2 (AML with maturation)?

A. t(15;17)

B. t(8;21)

C. t(8;14)

D. t(11;17)

172 / 210

Category: Hematology

172. Which of the following disorder is associated with left shift with toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score?

A. Basophilic stipplings

B. Neutrophilic leukemoid reaction (NLR)

C. Chronic myelogenous leukemia

D. Acute myelogenous leukemia

173 / 210

Category: Hematology

173. What is the primary site of hematopoiesis in the third month of gestation?

A. Spleen

B. Marrow of long bones

C. Liver

D. Yolk sac

174 / 210

Category: Hematology

174. What does the term "poikilocytosis" mean?

A. Variations in size

B. Variations in shape

C. Variation of central palor

D. Variations in color

175 / 210

Category: Hematology

175. Di Guglielmo syndrome is also classified as?

A. Acute megakaryocytic leukemia (AMegL; FAB M7)

B. Acute erythroleukemia; FAB M6

C. Acute myelomonocytic leukemia ;AMML; FAB M4

D. Acute promyelocytic leukemia (APL); FAB M3

176 / 210

Category: Hematology

176. This abnormality is caused by mutation in LYST gene, what is this cell?

A. Gaucher Disease

B. May Hegglin Anomally

C. Alder Anomaly

D. Chediak Higashi

177 / 210

Category: Hematology

177. What is the primary site for pre-B cell differentiation ?

A. Liver

B. Spleen

C. Thymus

D. Bone marrow

178 / 210

Category: Hematology

178. What red cell morphologic abnormality have unevenly pointed projections and associated with abetalipoproteinemia

A. Spherocytes

B. Echinocytes

C. Dacrocytes

D. Acanthocytes

179 / 210

Category: Hematology

179. Impaired release of storage iron due to increased hepcidin levels will result in ?

A. Thalassemia

B. Sideroblastic anemia

C. Anemia of Chronic Inflammation

D. Iron-deficiency anemia

180 / 210

Category: Hematology

180. Deficiency of intrinsic factors causes?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Lead poisoning

D. Pernicious anemia

181 / 210

Category: Hematology

181. Basophilic stippling is composed of

A. Vitamin K

B. RNA

C. Iron granules

D. DNA

182 / 210

Category: Hematology

182. Which of the following is a lipid storage disorder caused by deficiency in glucocerebrosidase

A. Niemann-Pick disease

B. Gaucher disease

C. Alder normally

D. Chronic granulomatous disease (CGD)

183 / 210

Category: Hematology

183. Which of the following stain is used to visualize iron granules in RBCs?

A. Prussian blue

B. Wright's stain

C. Supravital stain

D. New methylene Blue

184 / 210

Category: Hematology

184. Which of the following characterizes Vitamin B12 deficiency Anemia?

A. Decreased methylmalonic acid (MMA), Increased homocysteine

B. Increased methylmalonic acid (MMA), Increased homocysteine

C. Decreased methylmalonic acid (MMA), Decreased homocysteine

D. Decreased methylmalonic acid (MMA), Increased homocysteine

185 / 210

Category: Hematology

185. What is the expected result of a solubility test for patients with Hgb SS disease?

A. Negative

B. Positive

186 / 210

Category: Hematology

186. Which type of anemia will cause iron overload?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

187 / 210

Category: Hematology

187. Which type of hemoglobin is produced in the mesoblastic phase?

A. Portland

B. Hgb F

C. Hgb A

D. Portland, Gower I and Gower II

188 / 210

Category: Hematology

188. Basophilia is associated with?

A. Type I hypersensitivity reactions

B. Leukemoid reaction (NLR)

C. Chronic myelogenous leukemia

D. Type I hypersensitivity reactions and chronic myelogenous leukemia

189 / 210

Category: Hematology

189. A 25-year-old woman complains to his physician of extreme fatigue. Her CBC results are as follows:


WBC	6.8 x 10^9/L
RBC	3.9 x 10^12/L
Hemoglobin	9.2 g/dL
Hematocrit	30%
MCV	77fl
MCH	24 pg
MCHC	31 g/dL

Serum Iron	Ferritin	RDW	TIBC	Prussian blue stain
Decreased	Decreased	Decreased	Increased	Absent iron stores

The results of the CBC and iron studies, in this case, are most characteristic of?

A. Iron deficiency

B. Megaloblastic anemia

C. Sideroblastic anemia

D. Anemia of chronic disease

190 / 210

Category: Hematology

190. This rod is associated with acute promyelocytic leukemia(AML). Identify the cell?

A. Howell Jolly Bodies

B. Auer rods

C. Plasma cell

D. Reactive Lymphocytes

191 / 210

Category: Hematology

191. What structure do methylene blue stain?

A. DNA

B. RNA

C. Hemoglobin

D. DNA and RNA

192 / 210

Category: Hematology

192. What is this cell multi-lobed cells called?

A. Lymphocytes

B. Segmented Neutrophils

C. Monocytes

D. Eosinophils

193 / 210

Category: Hematology

193. What is an excessive accumulation of iron in body tissues called?

A. Hematoma

B. Heme toxicity

C. Hematopenia

D. Hemochromatosis

194 / 210

Category: Hematology

194. What is the most common enzyme deficiency in Embden Meyerhof Pathway?

A. G6PD (glucose-6-phosphate dehydrogenase) deficiency

B. Hereditary spherocytosis

C. Pyruvate kinase (PK) deficiency

D. Paroxysmal nocturnal hemoglobinuria (PNH)

195 / 210

Category: Hematology

195. Which stain is used to enumerate reticulocytes ?

A. New methylene blue

B. Wright stain

C. Grams stain

D. Eosin stain

196 / 210

Category: Hematology

196. What is the normal ratio of myeloid to erythroid precursors in the bone marrow (M:E ratio)?

A. 2:1

B. 3:1

C. 5:1

D. 1:1

197 / 210

Category: Hematology

197. What are the stages of erythrocyte maturation from the earliest recognizable stage ?

A. Rubriblast, Prorubricyte, rubricyte, metarubricyte, reticulocyte

B. Rubriblast, rubricyte, prorubricyte, metarubricyte, reticulocyte

C. Rubriblast, rubricyte, metarubricyte, reticulocyte

D. Rubriblast, metarubricyte, reticulocyte

198 / 210

Category: Hematology

198. Which of the following factors will result in an immediate increase in oxygen delivery to the tissues ?

A. decreased body temperature

B. low 2,3-bisphosphoglycerate (2,3-BPG) level

C. Decreased pH

D. Decreased carbon release

199 / 210

Category: Hematology

199. Which gene mutation is associated with chronic myelogenous leukemia?

A. JAK2 oncogene

B. t(8;11)

C. t(8;14)

D. BCR/ABL oncogene

200 / 210

Category: Hematology

200. Basophilia is associated with ?

A. Type I hypersensitivity reactions

B. Leukemoid reaction (NLR)

C. Type I hypersensitivity reactions and chronic myelogenous leukemia

D. Chronic myelogenous leukemia

201 / 210

Category: Hematology

201. What is the process of blood cell formation called?

A. Hemochromatosis

B. Apotosis

C. Hematopoiesis

D. Mitosis

202 / 210

Category: Hematology

202. What are the two primary lymphoid tissues ?

A. Spleen and liver

B. Thymus and liver

C. Bone marrow and spleen

D. Bone marrow and thymus

203 / 210

Category: Hematology

203. Which of the following protein stimulates red blood cell production?

A. Erythropoietin

B. Transferrin

C. Hemopexin

D. Prealbumin

204 / 210

Category: Hematology

204. What is the pH of blood ?

A. 7.35-7.45

B. 7.25-7.45

C. 7.30-7.45

D. 7.32-7.49

205 / 210

Category: Hematology

205. Auer rods will stain positive in which of the following stains?

A. Myeloperoxidase (MPO) and Sudan black B

B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS)

C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains

206 / 210

Category: Hematology

206. What is the structure of the hemoglobin molecule ?

A. Two heme groups, two globin chains

B. Four heme groups, two globin chains

C. Four heme groups, four globin chains

D. Two heme groups, four globin chains

207 / 210

Category: Hematology

207. Which of the following is associated with a "shift to the right" in the oxygen dissociation curve of hemoglobin ?

A. Decreased oxygen release

B. Increased pH, high 2,3-bisphosphoglycerate and increased body temperature

C. Decreased pH, high 2, 3-bisphosphoglycerate and elevated temperature

D. Decreased carbon release

208 / 210

Category: Hematology

208. What is the primary site of hematopoiesis in the fifth month of gestation?

A. Spleen

B. Marrow of long bones

C. Liver

D. Yolk sac

209 / 210

Category: Hematology

209. Which hemoglobin forms are incapable of oxygen transport ?

A. Deoxyhemoglobin and carboxyhemoglobin

B. Methemoglobin and deoxyhemoglobin

C. Oxyhemoglobin and deoxyhemoglobin

D. Carboxyhemoglobin and methemoglobin

210 / 210

Category: Hematology

210. Which malignant disorder is associated with left shift with myelocytes the predominate cell?

A. Acute myelogeneous leukemia

B. Chronic myelogenous leukemia

C. Acute promyelocytic leukemia (APL); FAB M3

D. Acute megakaryocytic leukemia (AMegL; FAB M7)

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