Hematology Test Bank -

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Hematology Question Bank

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Category: Hematology

1. What are the three stages of hematopoiesis?

A. Meroblastic phase, hepatic phase, and medullary phase

B. Mesoblastic phase, primitive phase, and medullary phase

C. Primitive phase, definitive phase and hepatic phase

D. Mesoblastic phase, hepatic phase, and medullary phase

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Category: Hematology

2. Which of the following clinical finding is associated with Hgb SS disease?

A. Bone marrow erythroid hyperplasia

B. Decreased haptoglobin

C. Positive hemoglobin solubility

D. All of the above

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Category: Hematology

3. Blood loss caused by gastrointestinal bleeding is classified as

A. Chronic blood loss

B. Reticulocytosis

C. Acute blood loss

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Category: Hematology

4. Deficiency of intrinsic factors causes?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Lead poisoning

D. Pernicious anemia

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Category: Hematology

5. Decrease in absolute number of neutrophils is called ?

A. Eosinophilia

B. Leukopenia

C. Neutropenia

D. Leukocytosis

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Category: Hematology

6. Pappenheimer bodies are composed of ?

A. Vitamin K

B. RNA

C. Iron granules

D. DNA

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Category: Hematology

7. Which type of anemia will cause iron overload?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

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Category: Hematology

8. Calculate percent transferrin

Serum iron is 22 μg/dL

TIBC is 180 μg/dL

A. 17%

B. 25%

C. 12%

D. 15%

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Category: Hematology

9. What is the MCV?


Hemoglobin	14.9 g/dL
RBC	4.84 x 10^12/L
Hematocrit	44.4%

A. 104fL

B. 79fL

C. 91.7fl

D. 99fL

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Category: Hematology

10. Which lymphoma has Reed-Sternberg cells?

A. Hodgkin lymphoma

B. Non-Hodgkin lymphoma

C. Acute lymphocytic leukemia (CLL)

D. Chronic myelogenous leukemia (CML)

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Category: Hematology

11. What does the term "poikilocytosis" mean?

A. Variations in size

B. Variations in shape

C. Variation of central palor

D. Variations in color

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Category: Hematology

12. Which macrocytic anemia affects the Central Nervous System?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Folate deficiency

D. Vitamin B12 deficiency

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Category: Hematology

13. A sudden loss of blood from traumatic injuries is..

A. Chronic blood loss

B. Reticulocytosis

C. Acute blood loss

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Category: Hematology

14. Antigen-independent lymphopoiesis occurs in

A. Liver and spleen

B. Spleen and kidney

C. Peyer's patches and spleen

D. Thymus and bone marrow

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Category: Hematology

15. World Health Organization (WHO) defines acute leukemia as?

A. >20% bone marrow blasts.

B. >30% bone marrow blasts.

C. >70% bone marrow blasts.

D. >50% bone marrow blasts.

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Category: Hematology

16. Which gene mutation is implicated in polycythemia?

A. JAK2 oncogene

B. t(8;11)

C. BCR/ABL oncogene

D. t(11;17)

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Category: Hematology

17. In what condition would an LAP score of 10 most likely be found?

A. Bacterial septicemia

B. Late pregnancy

C. Polycythemia vera

D. Chronic myelogenous leukemia

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Category: Hematology

18. What is an excessive accumulation of iron in body tissues called?

A. Hematoma

B. Heme toxicity

C. Hematopenia

D. Hemochromatosis

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Category: Hematology

19. Where is erythropoietin produced ?

A. Brain

B. Spleen

C. Liver

D. Kidney

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Category: Hematology

20. Senescent RBCs are phagocytized by macrophages in the liver or spleen and removed through

A. Extravascular hemolysis

B. Intravascular hemolysis

C. Necrosis

D. Cell degeneration

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Category: Hematology

21. Which of the following test is used to measure bone marrow erythropoiesis?

A. Hams Sugar test

B. Reticulocyte count

C. Erythrocyte Sedimentation Rate

D. Cell count

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Category: Hematology

22. What is the MCH?


Hemoglobin	11.1 g/dL
RBC	3.65 x 10^12/L
Hematocrit	32.5%

A. 31pg

B. 33 pg

C. 30.9pg

D. 30.4pg

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Category: Hematology

23. Which hemolytic anemia is caused due to a deficiency of the enzyme ADAMTS 13?

A. Paroxysmal nocturnal hemoglobinuria (PNH)

B. Hemolytic uremic syndrome (HUS)

C. Microangiopathic hemolytic anemias (MAHAs)

D. Thrombotic thrombocytopenic purpura (TTP)uremic syndrome (HUS)

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Category: Hematology

24. Which of the following differentiates non-megaloblastic macrocytic anemias from megaloblastic anemias?

A. Oval erythrocytes in non-megaloblastic macrocytic

B. Round erythrocytes in megaloblastic anemias

C. Hypersegmented neutrophil in non-megaloblastic macrocytic

D. Round erythrocytes in non-megaloblastic macrocytic

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Category: Hematology

25. Which of the following characterizes sideroblastic anemia?

A. Serum iron decreased, transferrin decreased

B. Serum iron decreased, transferrin increased

C. Serum iron normal, transferrin normal

D. TIBC decreased, increased ferritin and serum iron

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Category: Hematology

26. Which of the following red blood cell precursors is the last stage to undergo mitosis?

A. Band neutrophils

B. Promyelocyte

C. Myelocyte

D. Segmented neutrophils

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Category: Hematology

27. What is the primary site of hematopoiesis in the fifth month of gestation?

A. Spleen

B. Marrow of long bones

C. Liver

D. Yolk sac

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Category: Hematology

28. Which gene mutation is implicated in Essential thrombocythemia (ET)?

A. JAK2 oncogene

B. t(8;11)

C. t(8;14)

D. BCR/ABL oncogene

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Category: Hematology

29. What is the first type of blood cell produced by the developing embryo?

A. Thrombocyte

B. Granulocyte

C. Lymphocytes

D. Erythrocytes

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Category: Hematology

30. Auer rods will stain positive in which of the following stains?

A. Myeloperoxidase (MPO) and Sudan black B

B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS)

C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains

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Category: Hematology

31. Which stain is used for reticulocyte count ?

A. Wright's stain

B. Supravital stain

C. New methylene Blue

D. Prussian blue

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Category: Hematology

32. Which of the following is associated with a "shift to the right" in the oxygen dissociation curve of hemoglobin ?

A. Decreased oxygen release

B. Increased pH, high 2,3-bisphosphoglycerate and increased body temperature

C. Decreased pH, high 2, 3-bisphosphoglycerate and elevated temperature

D. Decreased carbon release

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Category: Hematology

33. Which stain is used for reticulocyte count?

A. Prussian blue

B. Wright's stain

C. Supravital stain

D. New methylene Blue

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Category: Hematology

34. Microcytic, hypochromic red cells are most often associated with impaired

A. DNA synthesis

B. Hemoglobin synthesis

C. RNA metabolism

D. Enzyme metabolism

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Category: Hematology

35. Which of the following is a lipid storage disorder caused by deficiency in sphingomyelinase, associated with foamy bone marrow appearance ?

A. Niemann-Pick disease

B. Gaucher disease

C. Alder normally

D. Chronic granulomatous disease (CGD)

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Category: Hematology

36. What is the normal ratio of myeloid to erythroid precursors in the bone marrow (M:E ratio)?

A. 2:1

B. 3:1

C. 5:1

D. 1:1

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Category: Hematology

37. Which of the following characterizes iron deficiency anemia?

A. Decreased serum iron, increased transferrin saturation, normal ferritin

B. Increased serum iron, decreased transferrin saturation, decreased ferritin

C. Decreased serum iron, decreased ferritin and Increased TIBC

D. Increased serum transferrin, increased ferritin, and decreased Total iron binding capacity (TIBC)

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Category: Hematology

38. What is this cell?

A. Dacrocytes

B. Reticulocyte

C. Codocytes

D. Elliptocytes

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Category: Hematology

39. Which term describes a decrease in all blood cell lines?

A. Pancytopenia

B. Cellopenia

C. Reticulocytosis

D. Nucleopenia

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Category: Hematology

40. Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

A. t(15;17); PML/RARA oncogene

B. t(8;11)

C. t(8;14)

D. t(11;17)

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Category: Hematology

41. What structure do methylene blue stain?

A. DNA

B. RNA

C. Hemoglobin

D. DNA and RNA

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Category: Hematology

42. Which neutrophil abnormality is caused by MYH9 gene mutation, and characterized by the presence of Dohle-like bodies, giant platelets and thrombocytopenia?

A. Pelger Huet Anomaly

B. May-Hegglin anomaly

C. Chediak-Higashi syndrome

D. Chronic granulomatous disease (CGD)

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Category: Hematology

43. What is the primary site of hematopoiesis in the third month of gestation?

A. Spleen

B. Marrow of long bones

C. Liver

D. Yolk sac

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Category: Hematology

44. Which of the following stain is used in the diagnosis of Hairy cell leukemia?

A. Periodic acid-Schiff (PAS)

B. Nonspecific esterase stains

C. Sudan Black

D. Tartrate-resistant acid phosphatase stain (TRAP)

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Category: Hematology

45. What is the pH of blood?

A. 7.25-7.45

B. 7.30-7.45

C. 7.32-7.49

D. 7.35-7.45

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Category: Hematology

46. What is this cell?

A. Monocytes

B. Eosinophils

C. Lymphocytes

D. Basophils

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Category: Hematology

47. The majority of iron found in an adult is a constituent of

A. Haptoglobin

B. Myoglobin

C. Hemoglobin

D. Propyria

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Category: Hematology

48. Granulocytic cells will stain positive in which of the following stains?

A. Myeloperoxidase (MPO), Sudan black B, and Specific esterase stain

B. Myeloperoxidase (MPO), Periodic acid-Schiff (PAS), and non- specific esterase stain

C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains

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Category: Hematology

49. What is the genetic translocation in FAB L3/Burkitt lymphoma?

A. t(15;17)

B. t(8;11)

C. t(8;14); with a rearrangement of the MYC oncogene

D. t(11;17)

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Category: Hematology

50. An aggressive form of cutaneous T-cell lymphoma is?

A. Sezary syndrome

B. Mycosis fungoides

C. Reed-Sternberg syndrome

D. Chronic myelogenous leukemia (CML)

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Category: Hematology

51. Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia?

A. Chronic lymphocytic leukemia (CLL)

B. Hairy cell leukemia (HCL)

C. Acute lymphocytic leukemia (CLL)

D. Chronic myelogenous leukemia (CML)

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Category: Hematology

52. Which hemoglobin migrates with with hemoglobins A2, E, and O on alkaline hemoglobin electropheroseis?

A. Hgb F

B. Hgb C

C. Hgb SC

D. Hgb E

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Category: Hematology

53. The most common cause of aplastic anemia is?

A. Idiopathic

B. Diamond-Blackfan anemia

C. Fanconi anemia

D. Sideroblastic anemia

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Category: Hematology

54. Impaired DNA metabolism is characteristic of which type of anemia?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Lead poisoning

D. Vitamin B12 deficiency

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Category: Hematology

55. What structures do methylene blue stain?

A. DNA

B. RNA

C. Hemoglobin

D. DNA and RNA

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Category: Hematology

56. Which disorder occurs when glutamic acid is replaced by valine at position 6 on both beta chains.?

A. Hgb E

B. Hgb SC

C. Sickle Cell Disease (Hgb SS)

D. Hgb C

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Category: Hematology

57. Defective hemoglobin synthesis due to a block in the protoporphyrin pathway will result in which type of anemia?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

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Category: Hematology

58. What is the expected result of a solubility test for patients with Hgb SS disease?

A. Negative

B. Positive

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Category: Hematology

59. Which of the following disorders is associated with left shift, toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score ?

A. Basophilic stipplings

B. Chronic myelogenous leukemia

C. Neutrophilic leukemoid reaction (NLR)

D. Acute myelogenous leukemia

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Category: Hematology

60. What is the MCH?


Hemoglobin	14.1 g/dL
RBC	4.12 x 10^12/L
Hematocrit	41.3%

A. 34.2pg

B. 29.2pg

C. 32.2pg

D. 27.2pg

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Category: Hematology

61. Howell-Jolly bodies are composed of

A. Vitamin K

B. RNA

C. Iron granules

D. DNA

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Category: Hematology

62. Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

A. Reed-Sternberg cells

B. Mycosis fungoides

C. Sezary syndrome

D. Smudge cells

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Category: Hematology

63. Which of the following cell type will stain negative in Myeloperoxidase (MPO) stains?

A. Granulocytic cells

B. Auer rods stain

C. Lymphocytic cells

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Category: Hematology

64. Which neutrophil abnormality is caused by mutation in Lamin B receptor and characterized by the presence of bilobed neutrophils ?

A. Pelger Huet Anomaly

B. Chediak-Higashi syndrome

C. May-Hegglin anomaly

D. Chronic granulomatous disease (CGD)

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Category: Hematology

65. What is this cell?

A. Dacrocytes

B. Schistocytes

C. Echinocytes

D. Acanthocytes

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Category: Hematology

66. This abnormality is caused by mutation in LYST gene, what is this cell?

A. Gaucher Disease

B. May Hegglin Anomally

C. Alder Anomaly

D. Chediak Higashi

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Category: Hematology

67. Burkitt lymphoma is associated with which of the following virus?

A. Polio Virus

B. Rotavirus

C. Coxcakie Virus

D. Epstein Barr Virus

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Category: Hematology

68. Which type of hemoglobin is produced in the mesoblastic phase?

A. Portland

B. Hgb F

C. Hgb A

D. Portland, Gower I and Gower II

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Category: Hematology

69. The presence of the chromosomal abnormality t(15;17) with disseminated intravascular coagulation (DIC) is diagnostic of?

A. Acute myeloblastic leukemia without maturation (FAB type Ml)

B. Acute myeloblastic leukemia with maturation (FAB type M2)

C. Acute promyelocytic leukemia (FAB type M3)

D. Acute myelomonocytic leukemia (FAB type M4)

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Category: Hematology

70. Which of the following characterizes anemia of chronic inflammation?

A. Serum iron Increased, transferrin decreased, and increased ferritin

B. Serum iron decreased, transferrin decreased, and decreased ferritin

C. Serum iron increased, Increased transferrin, and decreased ferritin

D. Serum iron decreased, ferritin increased, and decreased Total Iron Binding Capacity(TIBC)

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Category: Hematology

71. Which of the following disorder is associated with left shift with toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score?

A. Basophilic stipplings

B. Neutrophilic leukemoid reaction (NLR)

C. Chronic myelogenous leukemia

D. Acute myelogenous leukemia

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Category: Hematology

72. Impaired DNA metabolism is characteristic of which type of anemia?

A. Folic acid deficiency

B. Iron deficiency anemia

C. Sideroblastic anemia

D. Lead poisoning

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Category: Hematology

73. Which type of anemia is associated with hypersegmented neutrophils?

A. Sideroblastic anemia

B. Megaloblastic anemia

C. Microcytic anemia

D. Thalassemia

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Category: Hematology

74. Which cell type is predominant in acute myelogeneous leukemia?

A. lymphoblasts

B. myeloblasts

C. lymphocytes

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Category: Hematology

75. Which of the following anemia is associated with dwarfism and mental retardation?

A. Diamond-Blackfan anemia

B. Fanconi anemia

C. Sideroblastic anemia

D. Aplasia

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Category: Hematology

76. Which malignant disorder is characterized by the presence of oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia and abnormal morphology associated with all cell lines ?

A. Acute erythroleukemia

B. Acute myelomonocytic leukemia

C. Acute promyelocytic leukemia (APL)

D. Myelodysplastic Syndromes (MDSs)

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Category: Hematology

77. Thalassemias are the result of a?

A. Structural defect in the globin portion of hemoglobin

B. Quantitative defect in globin-chain synthesis

C. Qualitative defect in globin-chain structure

D. Qualitative defect in heme structure

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Category: Hematology

78. Impaired release of storage iron due to increased hepcidin levels will result in ?

A. Thalassemia

B. Sideroblastic anemia

C. Anemia of Chronic Inflammation

D. Iron-deficiency anemia

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Category: Hematology

79. Which erythrocyte metabolic pathway generates 2,3-bisphosphoglycerate ?

A. Embden-Meyerhof

B. Hexose monophosphate

C. Rapoport-Luebering

D. Methemoglobin reductase

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Category: Hematology

80. Which protein transports hemoglobin dimers resulting from intravascular hemolysis ?

A. Hemopexin

B. Albumin

C. Haptoglobin

D. Hemosiderin

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Category: Hematology

81. Identify the cell

A. Microcytic normochromic red blood cells

B. Microcytic hypochromic red blood cells

C. Macrocytic red blood cells

D. Normochromic red blood cells

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Category: Hematology

82. Which abnormal red blood cell is seen in abetalipoproteinemia?

A. Spherocytes

B. Acanthocytes

C. Echinocytes

D. Codocytes

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Category: Hematology

83. Which hemolytic anemia occurs most often in children following E. coli infection?

A. Paroxysmal nocturnal hemoglobinuria (PNH)

B. Hemolytic uremic syndrome (HUS)

C. Microangiopathic hemolytic anemias (MAHAs)

D. Thrombotic thrombocytopenic purpura (TTP)

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Category: Hematology

84. What is the primary site for pre-B cell differentiation ?

A. Liver

B. Spleen

C. Thymus

D. Bone marrow

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Category: Hematology

85. Hemoglobinopathies are inherited disorders caused by

A. Amino acid substitutions

B. Block in NADPH

C. Abnormal Hemoglobin structure

D. Peptide mutation

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Category: Hematology

86. Impaired DNA metabolism is characteristic of which type of anemia?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

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Category: Hematology

87. What is this cell?

A. Dacrocytes

B. Reticulocyte

C. Target cells

D. Elliptocytes

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Category: Hematology

88. In normocytic/normochromic anemia reticulocyte is

A. Increased

B. Decreased

C. Normal

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Category: Hematology

89. Hemoglobin F consists of ?

A. Two alpha- and two beta-globin chains

B. Two alpha- and two gamma-globin chains

C. Two alpha- and two delta-globin chains

D. Four alpha- and two beta-globin chains

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Category: Hematology

90. Which of the following factors will result in an immediate increase in oxygen delivery to the tissues ?

A. decreased body temperature

B. low 2,3-bisphosphoglycerate (2,3-BPG) level

C. Decreased pH

D. Decreased carbon release

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Category: Hematology

91. What is the genetic translocation for FAB M2 (AML with maturation)?

A. t(15;17)

B. t(8;21)

C. t(8;14)

D. t(11;17)

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Category: Hematology

92. What is this cell?

A. Macrophages

B. Monocytes

C. Plasma cell

D. Reactive Lymphocytes

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Category: Hematology

93. This rod is associated with acute promyelocytic leukemia(AML). Identify the cell?

A. Howell Jolly Bodies

B. Auer rods

C. Plasma cell

D. Reactive Lymphocytes

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Category: Hematology

94. A 21-year-old woman complains to his physician of fatigue, dizziness, and craving for ice. Her results are as follows:

Based on her laboratory result, what is the cause of anemia?

WBC 4.8 x 10^9/L

RBC 3.75 x 10^12/L

Hemoglobin 9.8 g/dL

Hematocrit 29%

MCV 77.3 fL

MCHC 33.8 g/dL

Serum iron and ferritin is decreased

Elevated total iron-binding capacity (TIBC)

Blood smear shows microcytic hypochromic red blood cells

A. Anemia of Chronic Inflammation

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

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Category: Hematology

95. Basophilia is associated with?

A. Type I hypersensitivity reactions

B. Leukemoid reaction (NLR)

C. Chronic myelogenous leukemia

D. Type I hypersensitivity reactions and chronic myelogenous leukemia

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Category: Hematology

96. What is the average lifespan of a normal red blood cell ?

A. 90 days

B. 180 days

C. 120 days

D. 60 days

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Category: Hematology

97. Which erythrocyte metabolic pathway generates NADPH ?

A. Embden-Meyerhof

B. Hexose monophosphate

C. Rapoport-Luebering

D. Methemoglobin reductase

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Category: Hematology

98. What is this cell?

A. Elliptocytes

B. Dacrocytes

C. Red blood cells

D. Spherocytes

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Category: Hematology

99. Antigen-dependent lymphopoiesis occurs in secondary lymphoid tissue located in

A. Liver and spleen

B. Spleen and kidney

C. Peyer's patches and spleen

D. Thymus and bone marrow

100 / 210

Category: Hematology

100. Which of the following conditions is most commonly associated with pica?

A. Anemia of chronic inflammation

B. Alpha thalassemia

C. Iron deficiency

D. Lead poisoning

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Category: Hematology

101. An increased number of immature cell types in the peripheral blood is

A. Cell apoptosis

B. Cell degeneration

C. Right shift

D. Left shift

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Category: Hematology

102. Neutrophils with 5 or more lobes are called ?

A. Multisegmented neutrophils

B. Hypersegmented neutrophils

C. Hyposegmented neutrophils

D. Monosegmented neutrophils

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Category: Hematology

103. Which stain is used to enumerate reticulocytes ?

A. New methylene blue

B. Wright stain

C. Grams stain

D. Eosin stain

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Category: Hematology

104. Hemoglobin A2 consists of ?

A. Two alpha- and two beta-globin chains

B. Two alpha- and four beta-globin chains

C. Two alpha- and two delta-globin chains

D. Four alpha- and two beta-globin chains

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Category: Hematology

105. Which classification is based on cellular morphology and cytochemical stain results?

A. French-American-British (FAB)

B. World Health Organization (WHO)

C. Cancer Association Method

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Category: Hematology

106. Impaired DNA metabolism is characteristic of which type of anemia ?

A. Thalassemia

B. Sideroblastic anemia

C. Megaloblastic anemia

D. Iron-deficiency anemia

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Category: Hematology

107. What is the process of blood cell formation called?

A. Hemochromatosis

B. Apotosis

C. Hematopoiesis

D. Mitosis

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Category: Hematology

108. What does the term "anisocytosis" mean?

A. Variations in size

B. Variations in shape

C. Variation of central palor

D. Variations in color

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Category: Hematology

109. Which of the following is the most common cause of iron deficiency?

A. Bleeding

B. Increased need

C. Inadequate diet

D. Pregnancy

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Category: Hematology

110. Which of the following stain is used to visualize iron granules in RBCs ?

A. Wright's stain

B. Supravital stain

C. New methylene Blue

D. Prussian blue

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Category: Hematology

111. What does Wright's stain consist of?

A. Methylene blue and cresyl green

B. Methylene blue and eosin

C. Methylene blue and neutral red

D. Methylene blue and Giemsa stain

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Category: Hematology

112. What is a true increase in the number of lymphocytes called?

A. Absolute lymphopenia

B. Absolute lymphocytosis

C. Relative lymphocytosis

D. Absolute polycythemia

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Category: Hematology

113. Which of the following stain is used to visualize iron granules in RBCs?

A. Prussian blue

B. Wright's stain

C. Supravital stain

D. New methylene Blue

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Category: Hematology

114. French-American-British (FAB) defines acute leukemia as?

A. >20% bone marrow blasts.

B. >30% bone marrow blasts.

C. >70% bone marrow blasts.

D. >50% bone marrow blasts.

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Category: Hematology

115. Which of the following is a true red cell aplasia?

A. Diamond-Blackfan anemia

B. Fanconi anemia

C. Sideroblastic anemia

D. Aplasia

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Category: Hematology

116. Which chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

A. t(15;17)

B. t(8;11)

C. t(8;14)

D. t(11;17)

117 / 210

Category: Hematology

117. Diphyllobothrium latum is associated with the development of?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Lead poisoning

D. Vitamin B12 deficiency

118 / 210

Category: Hematology

118. Basophilia is associated with ?

A. Type I hypersensitivity reactions

B. Leukemoid reaction (NLR)

C. Type I hypersensitivity reactions and chronic myelogenous leukemia

D. Chronic myelogenous leukemia

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Category: Hematology

119. What is the MCHC?


Hemoglobin	14.1 g/dL
RBC	4.12 x 10^12/L
Hematocrit	41.3%

A. 34.2g/dL

B. 34.1g/dL

C. 32.2g/dL

D. 27.2g/dL

120 / 210

Category: Hematology

120. What red cell morphologic abnormality have unevenly pointed projections and associated with abetalipoproteinemia

A. Spherocytes

B. Echinocytes

C. Dacrocytes

D. Acanthocytes

121 / 210

Category: Hematology

121. What is the genetic translocation in chronic myelogenous leukemia (CML)?

A. t(15;17)

B. t(9;22)

C. t(8;14); with a rearrangement of the MYC oncogene

D. t(11;17)

122 / 210

Category: Hematology

122. What is this cell?

A. Dacrocytes

B. Reticulocyte

C. Sickle Cells

D. Elliptocytes

123 / 210

Category: Hematology

123. What is the primary site of hematopoiesis in the first month of gestation?

A. Spleen

B. Marrow of long bones

C. Liver

D. Yolk sac

124 / 210

Category: Hematology

124. Defective nuclear maturation commonly results in the production of red cells that are ?

A. Normocytic

B. Hypochromic

C. Macrocytic

D. Microcytic

125 / 210

Category: Hematology

125. Which of the following acquired hemolytic disorder causes intravascular hemolysis, presents with thrombocytopenia and schistocytes in peripheral blood smear?

A. Microangiopathic hemolytic anemias (MAHAs)

B. Paroxysmal nocturnal hemoglobinuria (PNH)

C. Hemolytic uremic syndrome (HUS)

D. Thrombotic thrombocytopenic purpura (TTP)

E. All of the above

126 / 210

Category: Hematology

126. Which of the following red blood cell morphology abnormalities is associated hemoglobinopathies?

A. Ovalocytes

B. Target cells

C. Echinocytes

D. Acanthocytes

127 / 210

Category: Hematology

127. What is the MCH?


Hemoglobin	14.9 g/dL
RBC	4.84 x 10^12/L
Hematocrit	44.4%

A. 30.8pg

B. 34pg

C. 36pg

D. 29pg

128 / 210

Category: Hematology

128. What is the MCV?


Hemoglobin	11.1 g/dL
RBC	3.65 x 10^12/L
Hematocrit	32.5%

A. 84fL

B. 79fL

C. 89fL

D. 92fL

129 / 210

Category: Hematology

129. Which of the following is the major transport protein of iron ?

A. Transferrin

B. Ferritin

C. Hemosiderin

D. Haptoglobin

130 / 210

Category: Hematology

130. What is the structure of the hemoglobin molecule ?

A. Two heme groups, two globin chains

B. Four heme groups, two globin chains

C. Four heme groups, four globin chains

D. Two heme groups, four globin chains

131 / 210

Category: Hematology

131. Which inclusion is seen in G6PD (glucose-6-phosphate dehydrogenase) deficiency?

A. Heinz bodies

B. Ringed sideroblasts

C. Howell jolly

D. Pappenheimer bodies

132 / 210

Category: Hematology

132. Which of the following is a lipid storage disorder caused by deficiency in glucocerebrosidase

A. Niemann-Pick disease

B. Gaucher disease

C. Alder normally

D. Chronic granulomatous disease (CGD)

133 / 210

Category: Hematology

133. Which of the following test is used to measure bone marrow erythropoiesis?

A. Hams Sugar test

B. Erythrocyte Sedimentation Rate

C. Reticulocyte count

D. Cell count

134 / 210

Category: Hematology

134. What are the two primary lymphoid tissues ?

A. Spleen and liver

B. Thymus and liver

C. Bone marrow and spleen

D. Bone marrow and thymus

135 / 210

Category: Hematology

135. What is an increase in the percentage of lymphocytes called?

A. Absolute lymphopenia

B. Absolute lymphocytosis

C. Relative lymphocytosis

D. Absolute polycythemia

136 / 210

Category: Hematology

136. Total iron binding capacity (TIBC) measures

A. Amount of transferrin

B. Amount of iron that transferrin can bind

C. Hepcidin

D. Ferritin

137 / 210

Category: Hematology

137. Which of the following inclusions is only visible with supravital stain?

A. Dohle bodies

B. Pappenheimer bodies

C. Basophilic stippling

D. Heinz bodies

138 / 210

Category: Hematology

138. A 27-year-old woman complains to his physician of pain and fatigue. Her results are as follows:

WBC 5.4 x 10^9/L

RBC 3.9 x 10^12/L

Hemoglobin 8.2 g/dL

Hematocrit 28%

MCV 72 fL

MCHC 29.3 g/dL

ESR increased

Serum iron and total iron-binding capacity (TIBC) both decreased

Serum ferritin slightly elevated.

Presence of Prussian-blue-stainable iron in bone marrow was also noted.

Based her laboratory result, what is the cause of anemia?

A. Sideroblastic anemia

B. Anemia of Chronic Inflammation

C. Iron-deficiency anemia

D. Megaloblastic anemia

139 / 210

Category: Hematology

139. What hemoglobin is predominant at birth ?

A. Portland

B. Hgb F

C. Gower I

D. Gower II

140 / 210

Category: Hematology

140. Which stain is useful in the diagnosis of acute monocytic leukemia (FAB M5)?

A. Myeloperoxidase (MPO)

B. Periodic acid-Schiff (PAS)

C. Nonspecific esterase stains

D. Sudan Black

141 / 210

Category: Hematology

141. What is the major storage form of iron?

A. Transferrin

B. Hemosiderin

C. Ferritin

D. Hemachromatin

142 / 210

Category: Hematology

142. In what condition would an LAP score of 180 most likely be found?

A. Bacterial septicemia

B. paroxysmal nocturnal hemoglobinuria

C. Polycythemia vera

D. Polycythemia vera and Bacterial septicemia

143 / 210

Category: Hematology

143. Which of the following is the most commonly used routine stain for blood smear?

A. Prussian blue

B. Wright's stain

C. Supravital stain

D. New methylene Blue

144 / 210

Category: Hematology

144. Which erythrocyte metabolic pathway generates adenosine triphosphate (ATP) through glycolysis?

A. Methemoglobin reductase

B. Rapoport-Luebering

C. Hexose monophosphate

D. Embden-Meyerhof

145 / 210

Category: Hematology

145. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia?

A. Low Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

B. High Leukocyte Alkaline Phosphatase (LAP) score in chronic myelogenous leukemia

C. High Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

D. Philadelphia chromosome, t (9; 22) score in leukemoid reaction

146 / 210

Category: Hematology

146. A neutrophil disorder caused by mutations in the LYST gene and associated oculocutaneous albinism is ?

A. Pelger Huet Anomaly

B. Chediak-Higashi syndrome

C. May-Hegglin anomaly

D. Chronic granulomatous disease (CGD)

147 / 210

Category: Hematology

147. Which type of anemia would you see ringed sideroblasts?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

148 / 210

Category: Hematology

148. What is the MCV?


Hemoglobin	14.1 g/dL
RBC	4.12 x 10^12/L
Hematocrit	41.3%

A. 104fL

B. 79fL

C. 100.2fL

D. 99fL

149 / 210

Category: Hematology

149. Which leukemia is characterized by a proliferation of megakaryoblasts and positivity for CD41, CD42, and CD61 by flow cytometry?

A. Acute erythroleukemia; FAB M6

B. Acute myelomonocytic leukemia ;AMML; FAB M4

C. Acute promyelocytic leukemia (APL); FAB M3

D. Acute megakaryocytic leukemia (AMegL; FAB M7)

150 / 210

Category: Hematology

150. Hgb D Disease is caused by substitution of glutamic acid with.

A. Lysine

B. Valine

C. Leucine

D. Glycine

151 / 210

Category: Hematology

151. What is this cell?

A. Hgb SS Crystals

B. Hgb SC Crystals

C. Hgb C Crystals

D. Hgb E Crystals

152 / 210

Category: Hematology

152. Which of the following stains are used to differentiate blasts of acute myelogenous leukemias (AMLs) from acute lymphoblastic leukemia (ALLs)?

A. Myeloperoxidase (MPO) and Sudan black B

B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS)

C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains

153 / 210

Category: Hematology

153. Adult hemoglobin consists of ?

A. Hgb F contains two alpha- and four beta-globin chains

B. Hgb A contains four alpha- and two beta-globin chains

C. Hgb A contains two alpha- and two beta-globin chains

D. Hgb F contains three alpha- and four beta-globin chains

154 / 210

Category: Hematology

154. Which cell type is predominant in acute lymphoblastic leukemia?

A. lymphoblasts

B. myeloblasts

C. granulocytes

155 / 210

Category: Hematology

155. Which classification for hematopoietic malignancy is the accepted standard for diagnosis?

A. French-American-British (FAB)

B. World Health Organization (WHO)

C. Cancer Association Method

156 / 210

Category: Hematology

156. Serum ferritin is an indirect measurement of

A. Tissue iron

B. Storage iron

C. Hemoglobin iron

D. Transferrin iron

157 / 210

Category: Hematology

157. What is a true increase in the number of lymphocytes called ?

A. Absolute lymphocytosis

B. Absolute lymphopenia

C. Relative lymphocytosis

D. Absolute polycythemia

158 / 210

Category: Hematology

158. What is the primary site for pre-T cell differentiation?

A. Liver

B. Spleen

C. Thymus

D. Bone marrow

159 / 210

Category: Hematology

159. Which protein regulates iron homeostasis ?

A. Hemosiderin

B. Transferrin

C. Hepcidin

D. Hemopexin

160 / 210

Category: Hematology

160. Which of the following is diagnostic of Multiple myeloma?

A. "M"-spike in the gamma-globulin region in serum electrophoresis

B. Bence Jones proteins in the urine

C. Excessive production IgM (macroglobulin)

D. production of excessive IgG (macroglobulin)

E. A ,B and D

161 / 210

Category: Hematology

161. Which neutrophil abnormality is associated with Vitamin B12 deficiency?

A. Hyposegmented neutrophil

B. Hypersegmented neutrophil

C. Enlarged neutrophils

D. Bilobed neutrophil

162 / 210

Category: Hematology

162. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia ?

A. Low Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

B. High Leukocyte Alkaline Phosphatase (LAP) score in chronic myelogenous leukemia

C. High Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

D. Philadelphia chromosome, t (9; 22) score in leukemoid reaction

163 / 210

Category: Hematology

163. What is an increase in the percentage of lymphocytes called ?

A. Absolute lymphopenia

B. Relative lymphocytosis

C. Absolute lymphocytosis

D. Absolute polycythemia

164 / 210

Category: Hematology

164. What does Wright's stain consist of ?

A. Methylene blue and cresyl green

B. Methylene blue and neutral red

C. Methylene blue and eosin

D. Methylene blue and Giemsa stain

165 / 210

Category: Hematology

165. A block in the protoporphyrin pathway resulting in defective hemoglobin synthesis is characteristic of which type of anemia?

A. Thalassemia

B. Porphyrias

C. Iron-deficiency anemia

D. Megaloblastic anemia

166 / 210

Category: Hematology

166. What is this cell multi-lobed cells called?

A. Lymphocytes

B. Segmented Neutrophils

C. Monocytes

D. Eosinophils

167 / 210

Category: Hematology

167. In Waldenstrom macroglobulinemia which immunoglobin is increasingly produced?

A. IgM

B. IgG

C. IgA

D. IgS

168 / 210

Category: Hematology

168. Which gene mutation is associated with chronic myelogenous leukemia?

A. JAK2 oncogene

B. t(8;11)

C. t(8;14)

D. BCR/ABL oncogene

169 / 210

Category: Hematology

169. What substance has a greater affinity for hemoglobin than oxygen ?

A. Carbon

B. Carbon dioxide

C. Carbonmonoxide

D. Oxide

170 / 210

Category: Hematology

170. What term describes a mature red blood cell that contains iron granules ?

A. Basophillic stippling

B. Siderocyte

C. Howell Jolly

D. Ringed sideroblast

171 / 210

Category: Hematology

171. Which malignant disorder is associated with left shift with myelocytes the predominate cell?

A. Acute myelogeneous leukemia

B. Chronic myelogenous leukemia

C. Acute promyelocytic leukemia (APL); FAB M3

D. Acute megakaryocytic leukemia (AMegL; FAB M7)

172 / 210

Category: Hematology

172. Smudge cell is seen in which of the following malignancy?

A. Chronic lymphocytic leukemia (CLL)

B. Hairy cell leukemia (HCL)

C. Acute lymphocytic leukemia (CLL)

D. Chronic myelogenous leukemia (CML)

173 / 210

Category: Hematology

173. Which stain is useful in the diagnosis of erythroleukemia (FAB M6) and acute lymphoblastic leukemia?

A. Myeloperoxidase (MPO)

B. Periodic acid-Schiff (PAS)

C. Nonspecific esterase stains

D. Sudan Black

174 / 210

Category: Hematology

174. Which hemoglobin migrates with Hgb S and Hgb G on alkaline hemoglobin electrophoresis?

A. Hgb F