Other Blood Group System Quiz -

For each blood group system you must know the antigens, antibody class, phase of reactivity in vitro tests, clinical significance, and other important unique charcteristics.

Blood group	Enzyme treatment	Immunoglobulin type	Disease Association
Kell Antigens: K (Kell), k (Cellano), Kp^a, Kp^b, Js^a, Js^b	No effect	IgG	McLeod phenotype
Duffy Fy^aand Fy^b Dosage effect	Destroys Fy^aand Fy^b	IgG	HTR and HDN Fy (a-b-) phenotype: resistant to malarial infection caused by Plasmodium vivax
Kidd (Jk) Jk^a, Jk^b, Jk3 Dosage effect, binds compliment	Enhanced	IgG	HTR and mild HDN Delayed Hemolytic transfusion reaction (DHTR) Jk (a–b–) phenotype: resist lysis in 2M Urea

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Other Blood Group System Quiz

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1. Which blood group antigen resist lysis in 2M Urea?

A. Kpa

B. Jsa

C. Jk (a–b–)

D. Fy (a–b–)

Duffy, MNS and Xga are destroyed by enzymes

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2. Which antigen is destroyed by enzymes?

A. Duffy

B. Rh

C. Kidd

D. Lewis

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3. Which antibody can be neutralized with pooled plasma to allow detection of other antibodies?

A. Anti- Yta

B. Anti-Lu

C. Anti-Sda

D. Anti-Ch (Chido)

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4. Which of the following are antibodies to low-frequency antigens?

A. Anti-Kpb

B. Anti-Jkb

C. Anti-Kpa and Anti Jsa

D. Anti-Kpb, Anti-Kpa and Anti Jsa

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5. Antigen that shows dosage must be rule out with?

A. Cold panel

B. Heterozygous

C. Homozygous cell

D. Auto adsorption

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6. Which of the following are antibodies to high frequency antigens?

A. Anti-Kpb

B. Anti-Jkb

C. Anti-Kpa and Anti Jsa

D. Anti-Lub, Anti-Kpb and Anti Jsb

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Category: Bloodbank

7. What is biphasic hemolysin?

A. Binds to RBCs at 37°C and activate complement at 4°C

B. Binds to RBCs at low temperatures and activate complement at 37°C

C. Binds to RBCs at 37°C and activate complement

D. Activate complement at 37°C

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8. Which antigen has a receptor for Haemophilus influenza?

A. Yta

B. Cra

C. Kna

D. AnWj

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Category: Bloodbank

9. Which blood group system is associated with resistance to P. vivax malaria?

A. Anti P

B. Anti- Fya

C. Anti Fya-b-

D. Anti-Jkb

Anti P is cold reactive antibody; while others are warm reactive antibodies.

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Category: Bloodbank

10. Which antibody does not fit with the others with respect to optimum phase of reactivity?

A. Anti Jka

B. Anti-Fya

C. Anti-S

D. Anti-P

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Category: Bloodbank

11. Which blood group system does Anti-Jk^a and Anti-Jk^b belong to?

A. Kell

B. Kidd

C. Duffy

D. Lutheran

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Category: Bloodbank

12. Which blood group antigen is located near the RBC membrane and present when S or s is inherited?

A. S antigen

B. G antigen

C. U Antigen

D. M antigen

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Category: Bloodbank

13. Which of the following antibody is an IgG biphasic antibody in Donath-Landsteiner antibody test?

A. Anti- Yta

B. Anti-Lu

C. Anti-P1

D. Lewis

The genes GYPA codes for glycophorin A for blood group M and N

The genes GYPB codes for glycophorin B for blood group S and s

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Category: Bloodbank

14. Which blood group system is produced by glycophorin A?

A. MNS

B. Ss

C. Lewis

D. MN

Anti-P₁ is easily inhibited with P₁ substance(Hydatid cyst fluid)

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Category: Bloodbank

15. Which antibody is neutralized by hydatid cyst fluid to allow detection of other antibodies?

A. Anti- Yta

B. Anti-Lu

C. Anti-I

D. Anti-P1

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Category: Bloodbank

16. Which autoantibody specificity is found in patients with Mycoplasma pneumonia?

A. Auto anti I

B. Anti P

C. Anti i

D. Anti Pk

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Category: Bloodbank

17. Which blood group system do Anti-Fy^a and Anti-Fy^bbelong to?

A. Kell

B. Kidd

C. Duffy

D. Lutheran

Anti Jka is warm antibody; while others are cold reactive antibodies.

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18. Which antibody does not fit with the others with respect to optimum phase of reactivity?

A. Anti M

B. Anti-P

C. Anti-I

D. Anti-Jka

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Category: Bloodbank

19. Which autoantibody is associated with early abortion?

A. Kell

B. Kidd

C. anti-PP1pk

D. anti-PP1pk and anti-P

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Category: Bloodbank

20. Which antibody can be neutralized with human breast milk?

A. Anti- Yta

B. Anti-Lu

C. Anti-I

D. Lewis

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Category: Bloodbank

21. Which autoantibody specificity is found in patients with paroxysmal cold hemoglobinuria?

A. Auto anti I

B. Anti P

C. Anti i

D. Anti Pk

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Category: Bloodbank

22. Which blood group system does Anti-Js^a and Anti-Js ^bbelong to?

A. Kell

B. Kidd

C. Duffy

D. Lutheran

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Category: Bloodbank

23. Which condition is X- linked and is associated with abnormal RBC morphology, compensated hemolytic anemia, neurological and muscular abnormalities ?

A. Rh null

B. McLeod phenotype

C. Stomatocytosis

D. Graves Disease

Kidd, Duffy, MNS blood groups are known for showing dosage

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Category: Bloodbank

24. Which of the following blood group antigens are known for showing dosage?

A. MNS

B. Duffy

C. Kidd

D. All of the above

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Category: Bloodbank

25. The antibody to this high prevalence antigen appears shiny and refractile under the microscope.

A. Anti- Yta

B. Anti-Sda

C. Anti-I

D. Anti-V

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Category: Bloodbank

26. Which antigens are strongly expressed on placental tissues?

A. Yta

B. Chido

C. Cromer

D. AnWj

MN, Kidd, Duffy are well developed at birth while P and Lutheran blood group system are poorly developed at birth

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Category: Bloodbank

27. Which blood group antigen is poorly developed at birth?

A. P

B. MN

C. Kidd

D. Duffy

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Category: Bloodbank

28. Which blood group system is associated with Chronic Granulomatous Disease (CGD)?

A. Anti P

B. Anti- Fya

C. Kell

D. Anti-Jkb

Plasma hemoglobin, ammonia, and K+ levels increases

Plasma Na+, pH and 2,3-BPG levels decreases.

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Category: Bloodbank

29. Which autoantibody is associated with Echinococcus granulosis?

A. Kidd

B. Kell

C. anti-PP1pk

D. anti-P1

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Category: Bloodbank

30.

Which antibody is most commonly associated with delayed hemolytic transfusion reactions?

A. Duffy

B. Kidd

C. Kell

D. MNS

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Category: Bloodbank

31. Which blood group system do K and k antigens belong to?

A. Kell

B. Lutheran

C. Duffy

D. Kidd

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Category: Bloodbank

32. Which antibody is neutralized by urine to allow detection of other alloantibodies?

A. Anti- Yta

B. Anti-Lu

C. Anti-Sda

D. Anti-V

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Category: Bloodbank

33. What genes are necessary for the production of Le^bAntigens?

A. Se genes

B. Le and Se genes

C. H genes

D. H and Se genes

The genes GYPA codes for glycophorin A for blood group M and N

The genes GYPB codes for glycophorin B for blood group S and s

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34. Which blood group system is produced by glycophorin B?

A. MNS

B. Ss

C. Lewis

D. MN

Plasma hemoglobin, ammonia, and K+ levels increases

Plasma Na+, pH and 2,3-BPG levels decreases.

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35. Which autoantibody specificity is found in patients with infectious mononucleosis?

A. Auto anti I

B. Anti P

C. Anti i

D. Anti Pk

MN, Kidd, Duffy are well developed at birth

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Category: Bloodbank

36. Which blood group antigen is well developed at birth?

A. P

B. Lu

C. Kidd

D. P1

Plasma hemoglobin, ammonia, and K+ levels increases

Plasma Na+, pH and 2,3-BPG levels decreases.

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Category: Bloodbank

37. Which blood group system is associated with McLeod phenotype?

A. Kidd

B. Kell

C. Duffy

D. Lutheran

Rh, Kidd, Lewis, P and I blood group are enhanced by enzymes

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Category: Bloodbank

38. Which antigen(s) is enhanced by enzymes?

A. Rh

B. Kidd

C. Lewis

D. All of the above

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Category: Bloodbank

39. Which antibody is neutralized in vitro by Lewis substance?

A. Anti- Yta

B. Anti-Lu

C. Anti-Sda

D. Lewis

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