Vascular and Thrombocyte Disorders Quiz

1. A storage pool defect disorder that is associated with the absence of alpha granules, presence of large platelets in peripheral smears, and thrombocytopenia.

2. Which of the following are platelet agonists?

3. Which hereditary thrombocytes disorder is associated with deficiency of von Williebrand factor, decreased aggregation response to ristocetin, and decreased vWF: RCo, vWF: Ag, and VIII: C ?

4. The reference value for mean platelet volume (MPV) is approximately?

5. What is the life span of platelets?

6. Which hemorrhagic disorder is associated with lack of glycoprotein IIb/IIIa, normal response with ristocetin, decreased aggregation response with ADP, epinephrine, and collagen? 

7. A vasodilator that inhibits platelet aggregation is called?

8. What should you do when you observe this on a peripheral smear?

9. A type of thrombocytosis characterized by increased platelet production, in response to thrombopoietin. 

10. What is platelet adhesion?

11. Which of the following when exposed during vessel injury activates the extrinsic pathway?

12. Vitamin C deficiency causes?

13. A hereditary thrombocytes disorder that is caused by lack of functional GPIb-IX-V complexes on the platelet surface, and is associated with presence of large platelets, increased MPV, decreased aggregation response to ristocetin, and normal vWF: RCo, vWF: Ag?

14. A protein that is released during vessel damage and activates the fibrinolytic system is called?

15. An X-linked hereditary disease characterized by thrombocytopenia with small platelet size, low MPV, decreased alpha granules and increased susceptibility to infections.

16. Which test will detect defects in platelet adhesion and aggregation?

17. A hereditary vascular disorder that causes thin blood vessel walls  and mucous membrane bleeding is?

18. When platelets adheres to neutrophils due to exposure to EDTA, this phenomenon is called?

19. A vascular disorder associated with hyperelastic skin and joint abnormalities is called?

20. Uncontrolled, malignant proliferation of platelets, not in response to thrombopoietin is called?

21. Which of the following drugs interferes with platelet functions?

22. A carrier protein for factor VIII is?

23. What is the gene defect in Wiskott-Aldrich syndrome?

24. Which of the following platelet secreted proteins induces platelet aggregation and vasoconstriction?

25. An acquired vascular disease associated with deposition of amyloid on skin and vascular walls.

26. When Fibrinogen attaches to Ilb/IIIa receptor and forms a platelet plug. What is this process called?

27. Which of the following assays are used to asses von Willebrand factor?

28. Which of the following platelet factors neutralizes heparin?

29. Which of the following platelet secreted proteins stimulates vasoconstriction when vessel injury occurs?

30. A storage pool hereditary disorder, characterized by oculocutaneous albinism, bleeding tendency, and lack of dense body granules is called?

31. Which hemorrhagic disorder is caused by the inability of fibrinogen to bind with platelets due to lack of glycoprotein IIb/IIIa(fibrinogen binding receptor)?

32. Which vitamin aids in collagen synthesis?