Hematology Question Bank Leave a Comment / By quizshell / January 11, 2022 123456789101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778798081828384858687888990919293949596979899100101102103104105106107108109110111112113114115116117118119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209 0% 0 votes, 0 avg 19 GOOD LUCK WELL DONE Created by quizshellHematology Question Bank 1 / 209 Category: Hematology 1. Which of the following characterizes Vitamin B12 deficiency Anemia? A. Decreased methylmalonic acid (MMA), Increased homocysteine B. Increased methylmalonic acid (MMA), Increased homocysteine C. Decreased methylmalonic acid (MMA), Decreased homocysteine D. Decreased methylmalonic acid (MMA), Increased homocysteine 2 / 209 Category: Hematology 2. Which cell transports oxygen and removes metabolic waste from the body ? A. White blood cells B. Platelets C. Red blood cells D. Plasma 3 / 209 Category: Hematology 3. Which gene mutation is implicated in Essential thrombocythemia (ET)? A. JAK2 oncogene B. t(8;11) C. t(8;14) D. BCR/ABL oncogene 4 / 209 Category: Hematology 4. The majority of iron found in an adult is a constituent of A. Haptoglobin B. Myoglobin C. Hemoglobin D. Propyria 5 / 209 Category: Hematology 5. What is the genetic translocation for FAB M2 (AML with maturation)? A. t(15;17) B. t(8;21) C. t(8;14) D. t(11;17) 6 / 209 Category: Hematology 6. Which stain is used for reticulocyte count? A. Prussian blue B. Wright's stain C. Supravital stain D. New methylene Blue 7 / 209 Category: Hematology 7. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia? A. Low Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction B. High Leukocyte Alkaline Phosphatase (LAP) score in chronic myelogenous leukemia C. High Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction D. Philadelphia chromosome, t (9; 22) score in leukemoid reaction 8 / 209 Category: Hematology 8. Basophilia is associated with ? A. Type I hypersensitivity reactions B. Leukemoid reaction (NLR) C. Type I hypersensitivity reactions and chronic myelogenous leukemia D. Chronic myelogenous leukemia 9 / 209 Category: Hematology 9. Senescent RBCs are phagocytized by macrophages in the liver or spleen and removed through A. Extravascular hemolysis B. Intravascular hemolysis C. Necrosis D. Cell degeneration 10 / 209 Category: Hematology 10. Diphyllobothrium latum is associated with the development of? A. Iron deficiency anemia B. Sideroblastic anemia C. Lead poisoning D. Vitamin B12 deficiency 11 / 209 Category: Hematology 11. What is the first type of blood cell produced by the developing embryo? A. Thrombocyte B. Granulocyte C. Lymphocytes D. Erythrocytes 12 / 209 Category: Hematology 12. Blood loss caused by gastrointestinal bleeding is classified as A. Chronic blood loss B. Reticulocytosis C. Acute blood loss 13 / 209 Category: Hematology 13. Where is erythropoietin produced ? A. Brain B. Spleen C. Liver D. Kidney 14 / 209 Category: Hematology 14. A 27-year-old woman complains to his physician of pain and fatigue. Her results are as follows: WBC 5.4 x 10^9/L RBC 3.9 x 10^12/L Hemoglobin 8.2 g/dL Hematocrit 28% MCV 72 fL MCHC 29.3 g/dL ESR increased Serum iron and total iron-binding capacity (TIBC) both decreased Serum ferritin slightly elevated. Presence of Prussian-blue-stainable iron in bone marrow was also noted. Based her laboratory result, what is the cause of anemia? A. Sideroblastic anemia B. Anemia of Chronic Inflammation C. Iron-deficiency anemia D. Megaloblastic anemia 15 / 209 Category: Hematology 15. What is the primary site for pre-B cell differentiation ? A. Liver B. Spleen C. Thymus D. Bone marrow 16 / 209 Category: Hematology 16. What hemoglobin is predominant at birth ? A. Portland B. Hgb F C. Gower I D. Gower II 17 / 209 Category: Hematology 17. Which type of hemoglobin is produced in the mesoblastic phase? A. Portland B. Hgb F C. Hgb A D. Portland, Gower I and Gower II 18 / 209 Category: Hematology 18. Which abnormal red blood cell is seen in abetalipoproteinemia? A. Spherocytes B. Acanthocytes C. Echinocytes D. Codocytes 19 / 209 Category: Hematology 19. Which erythrocyte metabolic pathway generates 2,3-bisphosphoglycerate ? A. Embden-Meyerhof B. Hexose monophosphate C. Rapoport-Luebering D. Methemoglobin reductase 20 / 209 Category: Hematology 20. Which disorder occurs when glutamic acid is replaced by valine at position 6 on both beta chains.? A. Hgb E B. Hgb SC C. Sickle Cell Disease (Hgb SS) D. Hgb C 21 / 209 Category: Hematology 21. Hgb D Disease is caused by substitution of glutamic acid with. A. Lysine B. Valine C. Leucine D. Glycine 22 / 209 Category: Hematology 22. Which of the following stain is used in the diagnosis of Hairy cell leukemia? A. Periodic acid-Schiff (PAS) B. Nonspecific esterase stains C. Sudan Black D. Tartrate-resistant acid phosphatase stain (TRAP) 23 / 209 Category: Hematology 23. Which neutrophil abnormality is caused by mutation in Lamin B receptor and characterized by the presence of bilobed neutrophils ? A. Pelger Huet Anomaly B. Chediak-Higashi syndrome C. May-Hegglin anomaly D. Chronic granulomatous disease (CGD) 24 / 209 Category: Hematology 24. What does Wright’s stain consist of? A. Methylene blue and cresyl green B. Methylene blue and eosin C. Methylene blue and neutral red D. Methylene blue and Giemsa stain 25 / 209 Category: Hematology 25. What substance has a greater affinity for hemoglobin than oxygen ? A. Carbon B. Carbon dioxide C. Carbonmonoxide D. Oxide 26 / 209 Category: Hematology 26. The presence of the chromosomal abnormality t(15;17) with disseminated intravascular coagulation (DIC) is diagnostic of? A. Acute myeloblastic leukemia without maturation (FAB type Ml) B. Acute myeloblastic leukemia with maturation (FAB type M2) C. Acute promyelocytic leukemia (FAB type M3) D. Acute myelomonocytic leukemia (FAB type M4) 27 / 209 Category: Hematology 27. What is the MCHC? Hemoglobin 11.1 g/dL RBC 3.65 x 10^12/L Hematocrit 32.5% A. 32.2g/dL B. 24.2g/dL C. 34.2g/dL D. 36.2g/dL 28 / 209 Category: Hematology 28. What does Wright’s stain consist of ? A. Methylene blue and cresyl green B. Methylene blue and neutral red C. Methylene blue and eosin D. Methylene blue and Giemsa stain 29 / 209 Category: Hematology 29. What is the average lifespan of a normal red blood cell ? A. 90 days B. 180 days C. 120 days D. 60 days 30 / 209 Category: Hematology 30. What structures do methylene blue stain? A. DNA B. RNA C. Hemoglobin D. DNA and RNA 31 / 209 Category: Hematology 31. What is this cell? A. Dacrocytes B. Reticulocyte C. Sickle Cells D. Elliptocytes 32 / 209 Category: Hematology 32. A sudden loss of blood from traumatic injuries is.. A. Chronic blood loss B. Reticulocytosis C. Acute blood loss 33 / 209 Category: Hematology 33. Which of the following is a lipid storage disorder caused by deficiency in glucocerebrosidase A. Niemann-Pick disease B. Gaucher disease C. Alder normally D. Chronic granulomatous disease (CGD) 34 / 209 Category: Hematology 34. Which malignant disorder is associated with left shift with myelocytes the predominate cell? A. Acute myelogeneous leukemia B. Chronic myelogenous leukemia C. Acute promyelocytic leukemia (APL); FAB M3 D. Acute megakaryocytic leukemia (AMegL; FAB M7) 35 / 209 Category: Hematology 35. Which malignant disorder is characterized by the presence of oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia and abnormal morphology associated with all cell lines ? A. Acute erythroleukemia B. Acute myelomonocytic leukemia C. Acute promyelocytic leukemia (APL) D. Myelodysplastic Syndromes (MDSs) 36 / 209 Category: Hematology 36. What is the MCV? Hemoglobin 14.1 g/dL RBC 4.12 x 10^12/L Hematocrit 41.3% A. 104fL B. 79fL C. 100.2fL D. 99fL 37 / 209 Category: Hematology 37. What is an increase in the percentage of lymphocytes called? A. Absolute lymphopenia B. Absolute lymphocytosis C. Relative lymphocytosis D. Absolute polycythemia 38 / 209 Category: Hematology 38. Hemoglobin A2 consists of ? A. Two alpha- and two beta-globin chains B. Two alpha- and four beta-globin chains C. Two alpha- and two delta-globin chains D. Four alpha- and two beta-globin chains 39 / 209 Category: Hematology 39. What is the MCHC? Hemoglobin 14.1 g/dL RBC 4.12 x 10^12/L Hematocrit 41.3% A. 34.2g/dL B. 34.1g/dL C. 32.2g/dL D. 27.2g/dL 40 / 209 Category: Hematology 40. What is the MCV? Hemoglobin 11.1 g/dL RBC 3.65 x 10^12/L Hematocrit 32.5% A. 84fL B. 79fL C. 89fL D. 92fL 41 / 209 Category: Hematology 41. What is the genetic translocation in chronic myelogenous leukemia (CML)? A. t(15;17) B. t(9;22) C. t(8;14); with a rearrangement of the MYC oncogene D. t(11;17) 42 / 209 Category: Hematology 42. Defective nuclear maturation commonly results in the production of red cells that are ? A. Normocytic B. Hypochromic C. Macrocytic D. Microcytic 43 / 209 Category: Hematology 43. Which hemoglobin migrates with Hgb S and Hgb G on alkaline hemoglobin electrophoresis? A. Hgb F B. Hgb C C. Hgb D D. Hgb SC 44 / 209 Category: Hematology 44. A block in the protoporphyrin pathway resulting in defective hemoglobin synthesis is characteristic of which type of anemia? A. Thalassemia B. Porphyrias C. Iron-deficiency anemia D. Megaloblastic anemia 45 / 209 Category: Hematology 45. Which type of anemia will cause iron overload? A. Thalassemia B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 46 / 209 Category: Hematology 46. Which of the following disorder is associated with left shift with toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score? A. Basophilic stipplings B. Neutrophilic leukemoid reaction (NLR) C. Chronic myelogenous leukemia D. Acute myelogenous leukemia 47 / 209 Category: Hematology 47. Which of the following stain is used to visualize iron granules in RBCs ? A. Wright's stain B. Supravital stain C. New methylene Blue D. Prussian blue 48 / 209 Category: Hematology 48. Identify the cell A. Microcytic normochromic red blood cells B. Microcytic hypochromic red blood cells C. Macrocytic red blood cells D. Normochromic red blood cells 49 / 209 Category: Hematology 49. World Health Organization (WHO) defines acute leukemia as? A. >20% bone marrow blasts. B. >30% bone marrow blasts. C. >70% bone marrow blasts. D. >50% bone marrow blasts. 50 / 209 Category: Hematology 50. Which type of anemia would you see ringed sideroblasts? A. Thalassemia B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 51 / 209 Category: Hematology 51. A cutaneous lymphoma that causes skin itching and ulcerative tumor are called? A. Mycosis fungoides B. Reed-Sternberg syndrome C. Waldenstrom macroglobulinemia 52 / 209 Category: Hematology 52. Which gene mutation is associated with chronic myelogenous leukemia? A. JAK2 oncogene B. t(8;11) C. t(8;14) D. BCR/ABL oncogene 53 / 209 Category: Hematology 53. What is this cell multi-lobed cells called? A. Lymphocytes B. Segmented Neutrophils C. Monocytes D. Eosinophils 54 / 209 Category: Hematology 54. What is the expected result of a solubility test for patients with Hgb SS disease? A. Negative B. Positive 55 / 209 Category: Hematology 55. Hemoglobinopathies are inherited disorders caused by A. Amino acid substitutions B. Block in NADPH C. Abnormal Hemoglobin structure D. Peptide mutation 56 / 209 Category: Hematology 56. Which of the following stains are used to differentiate blasts of acute myelogenous leukemias (AMLs) from acute lymphoblastic leukemia (ALLs)? A. Myeloperoxidase (MPO) and Sudan black B B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS) C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains 57 / 209 Category: Hematology 57. What is the oxidation state of iron in Hemoglobin ? A. Oxide state B. Ferrous state C. Peroxide state D. Ferric state 58 / 209 Category: Hematology 58. Which of the following characterizes iron deficiency anemia? A. Decreased serum iron, increased transferrin saturation, normal ferritin B. Increased serum iron, decreased transferrin saturation, decreased ferritin C. Decreased serum iron, decreased ferritin and Increased TIBC D. Increased serum transferrin, increased ferritin, and decreased Total iron binding capacity (TIBC) 59 / 209 Category: Hematology 59. What does the term “anisocytosis” mean? A. Variations in size B. Variations in shape C. Variation of central palor D. Variations in color 60 / 209 Category: Hematology 60. Hemoglobin F consists of ? A. Two alpha- and two beta-globin chains B. Two alpha- and two gamma-globin chains C. Two alpha- and two delta-globin chains D. Four alpha- and two beta-globin chains 61 / 209 Category: Hematology 61. Which test is used to differentiate Warm autoimmune hemolytic anemia (WAIHA) from hereditary spherocytosis? A. MCHC may be >37 g/dL B. Increased osmotic fragility C. Increased Bilirubin D. Positive direct antiglobulin test (DAT) 62 / 209 Category: Hematology 62. Adult hemoglobin consists of ? A. Hgb F contains two alpha- and four beta-globin chains B. Hgb A contains four alpha- and two beta-globin chains C. Hgb A contains two alpha- and two beta-globin chains D. Hgb F contains three alpha- and four beta-globin chains 63 / 209 Category: Hematology 63. Which of the following stains is used in distinguishing acute leukemias of myeloid origin from the monocytic origin? A. Myeloperoxidase (MPO) B. Periodic acid-Schiff (PAS) C. Nonspecific esterase stains 64 / 209 Category: Hematology 64. Which of the following characterizes sideroblastic anemia? A. Serum iron decreased, transferrin decreased B. Serum iron decreased, transferrin increased C. Serum iron normal, transferrin normal D. TIBC decreased, increased ferritin and serum iron 65 / 209 Category: Hematology 65. What is the genetic translocation in FAB L3/Burkitt lymphoma? A. t(15;17) B. t(8;11) C. t(8;14); with a rearrangement of the MYC oncogene D. t(11;17) 66 / 209 Category: Hematology 66. Which classification is based on cellular morphology and cytochemical stain results? A. French-American-British (FAB) B. World Health Organization (WHO) C. Cancer Association Method 67 / 209 Category: Hematology 67. Which of the following test is used to measure bone marrow erythropoiesis? A. Hams Sugar test B. Reticulocyte count C. Erythrocyte Sedimentation Rate D. Cell count 68 / 209 Category: Hematology 68. Granulocytic cells will stain positive in which of the following stains? A. Myeloperoxidase (MPO), Sudan black B, and Specific esterase stain B. Myeloperoxidase (MPO), Periodic acid-Schiff (PAS), and non- specific esterase stain C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains 69 / 209 Category: Hematology 69. Which cell type is predominant in acute myelogeneous leukemia? A. lymphoblasts B. myeloblasts C. lymphocytes 70 / 209 Category: Hematology 70. What is this cell? A. Dacrocytes B. Reticulocyte C. Codocytes D. Elliptocytes 71 / 209 Category: Hematology 71. Which hemolytic anemia is caused due to a deficiency of the enzyme ADAMTS 13? A. Paroxysmal nocturnal hemoglobinuria (PNH) B. Hemolytic uremic syndrome (HUS) C. Microangiopathic hemolytic anemias (MAHAs) D. Thrombotic thrombocytopenic purpura (TTP)uremic syndrome (HUS) 72 / 209 Category: Hematology 72. Which of the following cell type will stain negative in Myeloperoxidase (MPO) stains? A. Granulocytic cells B. Auer rods stain C. Lymphocytic cells 73 / 209 Category: Hematology 73. Which type of anemia is associated with hypersegmented neutrophils? A. Sideroblastic anemia B. Megaloblastic anemia C. Microcytic anemia D. Thalassemia 74 / 209 Category: Hematology 74. What are the two primary lymphoid tissues ? A. Spleen and liver B. Thymus and liver C. Bone marrow and spleen D. Bone marrow and thymus 75 / 209 Category: Hematology 75. What is the primary site for pre-T cell differentiation? A. Liver B. Spleen C. Thymus D. Bone marrow 76 / 209 Category: Hematology 76. Which of the following is the major transport protein of iron ? A. Transferrin B. Ferritin C. Hemosiderin D. Haptoglobin 77 / 209 Category: Hematology 77. Antigen-independent lymphopoiesis occurs in A. Liver and spleen B. Spleen and kidney C. Peyer's patches and spleen D. Thymus and bone marrow 78 / 209 Category: Hematology 78. Howell-Jolly bodies are composed of A. Vitamin K B. RNA C. Iron granules D. DNA 79 / 209 Category: Hematology 79. Pancytopenia is seen in which type of anemia? A. Iron deficiency anemia B. Sideroblastic anemia C. Aplastic anemia D. Anemia of chronic inflammation 80 / 209 Category: Hematology 80. Which gene mutation is implicated in polycythemia? A. JAK2 oncogene B. t(8;11) C. BCR/ABL oncogene D. t(11;17) 81 / 209 Category: Hematology 81. Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)? A. t(15;17); PML/RARA oncogene B. t(8;11) C. t(8;14) D. t(11;17) 82 / 209 Category: Hematology 82. Which of the following is an acquired membrane defect in which the red cell membrane has increased sensitivity for complement binding? A. Pyruvate kinase (PK) deficiency B. G6PD (glucose-6-phosphate dehydrogenase) deficiency C. Hereditary spherocytosis D. Paroxysmal nocturnal hemoglobinuria (PNH) 83 / 209 Category: Hematology 83. What is an increase in the percentage of lymphocytes called ? A. Absolute lymphopenia B. Relative lymphocytosis C. Absolute lymphocytosis D. Absolute polycythemia 84 / 209 Category: Hematology 84. Deficiency of intrinsic factors causes? A. Iron deficiency anemia B. Sideroblastic anemia C. Lead poisoning D. Pernicious anemia 85 / 209 Category: Hematology 85. What is the major storage form of iron? A. Transferrin B. Hemosiderin C. Ferritin D. Hemachromatin 86 / 209 Category: Hematology 86. Which term describes a decrease in all blood cell lines? A. Pancytopenia B. Cellopenia C. Reticulocytosis D. Nucleopenia 87 / 209 Category: Hematology 87. Which lymphoma has Reed-Sternberg cells? A. Hodgkin lymphoma B. Non-Hodgkin lymphoma C. Acute lymphocytic leukemia (CLL) D. Chronic myelogenous leukemia (CML) 88 / 209 Category: Hematology 88. What are the three stages of hematopoiesis? A. Meroblastic phase, hepatic phase, and medullary phase B. Mesoblastic phase, primitive phase, and medullary phase C. Primitive phase, definitive phase and hepatic phase D. Mesoblastic phase, hepatic phase, and medullary phase 89 / 209 Category: Hematology 89. Which erythrocyte metabolic pathway generates adenosine triphosphate (ATP) through glycolysis? A. Methemoglobin reductase B. Rapoport-Luebering C. Hexose monophosphate D. Embden-Meyerhof 90 / 209 Category: Hematology 90. Which of the following is found in biopsies of individuals with Hodgkin lymphoma? A. Reed-Sternberg cells B. Mycosis fungoides C. Sezary syndrome D. Smudge cells 91 / 209 Category: Hematology 91. Which of the following stain is used to visualize iron granules in RBCs? A. Prussian blue B. Wright's stain C. Supravital stain D. New methylene Blue 92 / 209 Category: Hematology 92. What is the MCV? Hemoglobin 14.9 g/dL RBC 4.84 x 10^12/L Hematocrit 44.4% A. 104fL B. 79fL C. 91.7fl D. 99fL 93 / 209 Category: Hematology 93. The most common cause of aplastic anemia is? A. Idiopathic B. Diamond-Blackfan anemia C. Fanconi anemia D. Sideroblastic anemia 94 / 209 Category: Hematology 94. Decreased haptoglobin is indicative of A. Extravascular hemolysis B. Intravascular hemolysis C. Intramedullary hematopoiesis D. Intermedullary hematopoiesis 95 / 209 Category: Hematology 95. Impaired release of storage iron due to increased hepcidin levels will result in ? A. Thalassemia B. Sideroblastic anemia C. Anemia of Chronic Inflammation D. Iron-deficiency anemia 96 / 209 Category: Hematology 96. Calculate percent transferrin Serum iron is 22 μg/dL TIBC is 180 μg/dL A. 17% B. 25% C. 12% D. 15% Transferrin Saturation %= Serum iron x 100 / TIBC 22 X 100 / 180 97 / 209 Category: Hematology 97. What red cell morphologic abnormality has evenly spaced round projections and is associated with pyruvate kinase deficiency A. Spherocytes B. Echinocytes C. Dacrocytes D. Acanthocytes 98 / 209 Category: Hematology 98. Which hemolytic anemia occurs most often in children following E. coli infection? A. Paroxysmal nocturnal hemoglobinuria (PNH) B. Hemolytic uremic syndrome (HUS) C. Microangiopathic hemolytic anemias (MAHAs) D. Thrombotic thrombocytopenic purpura (TTP) 99 / 209 Category: Hematology 99. Which of the following anemia is associated with dwarfism and mental retardation? A. Diamond-Blackfan anemia B. Fanconi anemia C. Sideroblastic anemia D. Aplasia 100 / 209 Category: Hematology 100. What is this cell? A. Macrophages B. Hairy Cell Leukemia C. Plasma cell D. Lymphocytes 101 / 209 Category: Hematology 101. What is the MCH? Hemoglobin 14.9 g/dL RBC 4.84 x 10^12/L Hematocrit 44.4% A. 30.8pg B. 34pg C. 36pg D. 29pg 102 / 209 Category: Hematology 102. What is this cell? A. Dacrocytes B. Reticulocyte C. Target cells D. Elliptocytes 103 / 209 Category: Hematology 103. What is the normal ratio of myeloid to erythroid precursors in the bone marrow (M:E ratio)? A. 2:1 B. 3:1 C. 5:1 D. 1:1 104 / 209 Category: Hematology 104. What is an excessive accumulation of iron in body tissues called? A. Hematoma B. Heme toxicity C. Hematopenia D. Hemochromatosis 105 / 209 Category: Hematology 105. Which chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)? A. t(15;17) B. t(8;11) C. t(8;14) D. t(11;17) 106 / 209 Category: Hematology 106. Which of the following disorders is associated with left shift, toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score ? A. Basophilic stipplings B. Chronic myelogenous leukemia C. Neutrophilic leukemoid reaction (NLR) D. Acute myelogenous leukemia 107 / 209 Category: Hematology 107. What is the pH of blood ? A. 7.35-7.45 B. 7.25-7.45 C. 7.30-7.45 D. 7.32-7.49 108 / 209 Category: Hematology 108. Which leukemia is characterized by a proliferation of megakaryoblasts and positivity for CD41, CD42, and CD61 by flow cytometry? A. Acute erythroleukemia; FAB M6 B. Acute myelomonocytic leukemia ;AMML; FAB M4 C. Acute promyelocytic leukemia (APL); FAB M3 D. Acute megakaryocytic leukemia (AMegL; FAB M7) 109 / 209 Category: Hematology 109. What is the pH of blood? A. 7.25-7.45 B. 7.30-7.45 C. 7.32-7.49 D. 7.35-7.45 110 / 209 Category: Hematology 110. Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia? A. Chronic lymphocytic leukemia (CLL) B. Hairy cell leukemia (HCL) C. Acute lymphocytic leukemia (CLL) D. Chronic myelogenous leukemia (CML) 111 / 209 Category: Hematology 111. Di Guglielmo syndrome is also classified as? A. Acute megakaryocytic leukemia (AMegL; FAB M7) B. Acute erythroleukemia; FAB M6 C. Acute myelomonocytic leukemia ;AMML; FAB M4 D. Acute promyelocytic leukemia (APL); FAB M3 112 / 209 Category: Hematology 112. Basophilia is associated with? A. Type I hypersensitivity reactions B. Leukemoid reaction (NLR) C. Chronic myelogenous leukemia D. Type I hypersensitivity reactions and chronic myelogenous leukemia 113 / 209 Category: Hematology 113. Which stain is useful in the diagnosis of erythroleukemia (FAB M6) and acute lymphoblastic leukemia? A. Myeloperoxidase (MPO) B. Periodic acid-Schiff (PAS) C. Nonspecific esterase stains D. Sudan Black 114 / 209 Category: Hematology 114. A 21-year-old woman complains to his physician of fatigue, dizziness, and craving for ice. Her results are as follows: Based on her laboratory result, what is the cause of anemia? WBC 4.8 x 10^9/L RBC 3.75 x 10^12/L Hemoglobin 9.8 g/dL Hematocrit 29% MCV 77.3 fL MCHC 33.8 g/dL Serum iron and ferritin is decreased Elevated total iron-binding capacity (TIBC) Blood smear shows microcytic hypochromic red blood cells A. Anemia of Chronic Inflammation B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 115 / 209 Category: Hematology 115. Which of the following cell markers are seen in B cell malignancy? A. CD19, and CD20 positive B. CD2, and CD4 positive C. CD2, CD19, and CD20 positive D. CD4, CD19, and CD20 positive 116 / 209 Category: Hematology 116. What is the primary site of hematopoiesis in the first month of gestation? A. Spleen B. Marrow of long bones C. Liver D. Yolk sac 117 / 209 Category: Hematology 117. What are the stages of granulocyte development ? A. Myeloblast, Promyelocyte, Myelocyte, Metamyelocyte, band neutrophils B. Myeloblast, Myelocyte, Promyelocyte, Metamyelocyte, band neutrophils C. Myeloblast, Myelocyte, Metamyelocyte, Promyelocyte, band neutrophils D. Myeloblast, Myelocyte, Metamyelocyte, band neutrophils 118 / 209 Category: Hematology 118. Chronic myeloproliferative disorders terminate in? A. Acute leukemia B. Chronic leukemia 119 / 209 Category: Hematology 119. Increased LAP score is seen in? A. Chronic myelogenous leukemia (CML) B. Paroxysmal nocturnal hemoglobinuria C. Neutrophilic leukemoid reaction 120 / 209 Category: Hematology 120. Which of the following is the most common cause of iron deficiency? A. Bleeding B. Increased need C. Inadequate diet D. Pregnancy 121 / 209 Category: Hematology 121. In what condition would an LAP score of 10 most likely be found? A. Bacterial septicemia B. Late pregnancy C. Polycythemia vera D. Chronic myelogenous leukemia 122 / 209 Category: Hematology 122. What is the process of blood cell formation called? A. Hemochromatosis B. Apotosis C. Hematopoiesis D. Mitosis 123 / 209 Category: Hematology 123. Which of the following red blood cell morphology abnormalities is associated hemoglobinopathies? A. Ovalocytes B. Target cells C. Echinocytes D. Acanthocytes 124 / 209 Category: Hematology 124. Hgb C Disease/Hgb CC is caused by substitution of glutamic acid with.. A. Lysine B. Valine C. Leucine D. Glycine 125 / 209 Category: Hematology 125. Microcytic, hypochromic red cells are most often associated with impaired A. DNA synthesis B. Hemoglobin synthesis C. RNA metabolism D. Enzyme metabolism 126 / 209 Category: Hematology 126. Defective hemoglobin synthesis due to a block in the protoporphyrin pathway will result in which type of anemia? A. Thalassemia B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 127 / 209 Category: Hematology 127. What red cell morphologic abnormality have unevenly pointed projections and associated with abetalipoproteinemia A. Spherocytes B. Echinocytes C. Dacrocytes D. Acanthocytes 128 / 209 Category: Hematology 128. What is this cell? A. Elliptocytes B. Dacrocytes C. Red blood cells D. Spherocytes 129 / 209 Category: Hematology 129. What is a true increase in the number of lymphocytes called ? A. Absolute lymphocytosis B. Absolute lymphopenia C. Relative lymphocytosis D. Absolute polycythemia 130 / 209 Category: Hematology 130. Which of the following inclusions is only visible with supravital stain? A. Dohle bodies B. Pappenheimer bodies C. Basophilic stippling D. Heinz bodies 131 / 209 Category: Hematology 131. An increased number of immature cell types in the peripheral blood is A. Cell apoptosis B. Cell degeneration C. Right shift D. Left shift 132 / 209 Category: Hematology 132. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia ? A. Low Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction B. High Leukocyte Alkaline Phosphatase (LAP) score in chronic myelogenous leukemia C. High Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction D. Philadelphia chromosome, t (9; 22) score in leukemoid reaction 133 / 209 Category: Hematology 133. Which of the following is a true red cell aplasia? A. Diamond-Blackfan anemia B. Fanconi anemia C. Sideroblastic anemia D. Aplasia 134 / 209 Category: Hematology 134. Which of the following red blood cell precursors is the last stage to undergo mitosis? A. Band neutrophils B. Promyelocyte C. Myelocyte D. Segmented neutrophils 135 / 209 Category: Hematology 135. Total iron binding capacity (TIBC) measures A. Amount of transferrin B. Amount of iron that transferrin can bind C. Hepcidin D. Ferritin 136 / 209 Category: Hematology 136. Which of the following characterizes anemia of chronic inflammation? A. Serum iron Increased, transferrin decreased, and increased ferritin B. Serum iron decreased, transferrin decreased, and decreased ferritin C. Serum iron increased, Increased transferrin, and decreased ferritin D. Serum iron decreased, ferritin increased, and decreased Total Iron Binding Capacity(TIBC) 137 / 209 Category: Hematology 137. Which of the following differentiates non-megaloblastic macrocytic anemias from megaloblastic anemias? A. Oval erythrocytes in non-megaloblastic macrocytic B. Round erythrocytes in megaloblastic anemias C. Hypersegmented neutrophil in non-megaloblastic macrocytic D. Round erythrocytes in non-megaloblastic macrocytic 138 / 209 Category: Hematology 138. Which protein regulates iron homeostasis ? A. Hemosiderin B. Transferrin C. Hepcidin D. Hemopexin 139 / 209 Category: Hematology 139. What is the MCH? Hemoglobin 11.1 g/dL RBC 3.65 x 10^12/L Hematocrit 32.5% A. 31pg B. 33 pg C. 30.9pg D. 30.4pg 140 / 209 Category: Hematology 140. Which classification for hematopoietic malignancy is the accepted standard for diagnosis? A. French-American-British (FAB) B. World Health Organization (WHO) C. Cancer Association Method 141 / 209 Category: Hematology 141. What are the stages of erythrocyte maturation from the earliest recognizable stage? A. Pronormoblast, normoblast, Polychromatophilic normoblast Orthochromic normoblast, Reticulocyte B. Pronormoblast, Basophilic normoblast, Polychromatophilic normoblast normoblast, Reticulocyte C. Pronormoblast, Basophilic normoblast, Polychromatophilic normoblast, Orthochromic normoblast, Reticulocyte D. Rubriblast, metarubricyte, reticulocyte, Basophilic normoblast 142 / 209 Category: Hematology 142. Which stain is used for reticulocyte count ? A. Wright's stain B. Supravital stain C. New methylene Blue D. Prussian blue 143 / 209 Category: Hematology 143. French-American-British (FAB) defines acute leukemia as? A. >20% bone marrow blasts. B. >30% bone marrow blasts. C. >70% bone marrow blasts. D. >50% bone marrow blasts. 144 / 209 Category: Hematology 144. Impaired DNA metabolism is characteristic of which type of anemia ? A. Thalassemia B. Sideroblastic anemia C. Megaloblastic anemia D. Iron-deficiency anemia 145 / 209 Category: Hematology 145. Which of the following acquired hemolytic disorder causes intravascular hemolysis, presents with thrombocytopenia and schistocytes in peripheral blood smear? A. Microangiopathic hemolytic anemias (MAHAs) B. Paroxysmal nocturnal hemoglobinuria (PNH) C. Hemolytic uremic syndrome (HUS) D. Thrombotic thrombocytopenic purpura (TTP) E. All of the above 146 / 209 Category: Hematology 146. Pappenheimer bodies are composed of ? A. Vitamin K B. RNA C. Iron granules D. DNA 147 / 209 Category: Hematology 147. Serum ferritin is an indirect measurement of A. Tissue iron B. Storage iron C. Hemoglobin iron D. Transferrin iron 148 / 209 Category: Hematology 148. What is this cell? A. Hgb SS Crystals B. Hgb SC Crystals C. Hgb C Crystals D. Hgb E Crystals 149 / 209 Category: Hematology 149. A neutrophil disorder caused by mutations in the LYST gene and associated oculocutaneous albinism is ? A. Pelger Huet Anomaly B. Chediak-Higashi syndrome C. May-Hegglin anomaly D. Chronic granulomatous disease (CGD) 150 / 209 Category: Hematology 150. This abnormality is caused by mutation in LYST gene, what is this cell? A. Gaucher Disease B. May Hegglin Anomally C. Alder Anomaly D. Chediak Higashi 151 / 209 Category: Hematology 151. Which of the following conditions is most commonly associated with pica? A. Anemia of chronic inflammation B. Alpha thalassemia C. Iron deficiency D. Lead poisoning 152 / 209 Category: Hematology 152. Which of the following factors will result in an immediate increase in oxygen delivery to the tissues ? A. decreased body temperature B. low 2,3-bisphosphoglycerate (2,3-BPG) level C. Decreased pH D. Decreased carbon release 153 / 209 Category: Hematology 153. What term describes a mature red blood cell that contains iron granules ? A. Basophillic stippling B. Siderocyte C. Howell Jolly D. Ringed sideroblast 154 / 209 Category: Hematology 154. Which stain is useful in the diagnosis of acute monocytic leukemia (FAB M5)? A. Myeloperoxidase (MPO) B. Periodic acid-Schiff (PAS) C. Nonspecific esterase stains D. Sudan Black 155 / 209 Category: Hematology 155. In normocytic/normochromic anemia reticulocyte is A. Increased B. Decreased C. Normal 156 / 209 Category: Hematology 156. Which hemoglobin migrates with with hemoglobins A2, E, and O on alkaline hemoglobin electropheroseis? A. Hgb F B. Hgb C C. Hgb SC D. Hgb E 157 / 209 Category: Hematology 157. What is the primary site of hematopoiesis in the fifth month of gestation? A. Spleen B. Marrow of long bones C. Liver D. Yolk sac 158 / 209 Category: Hematology 158. Burkitt lymphoma is associated with which of the following virus? A. Polio Virus B. Rotavirus C. Coxcakie Virus D. Epstein Barr Virus 159 / 209 Category: Hematology 159. Decrease in absolute number of neutrophils is called ? A. Eosinophilia B. Leukopenia C. Neutropenia D. Leukocytosis 160 / 209 Category: Hematology 160. What are the stages of erythrocyte maturation from the earliest recognizable stage ? A. Rubriblast, Prorubricyte, rubricyte, metarubricyte, reticulocyte B. Rubriblast, rubricyte, prorubricyte, metarubricyte, reticulocyte C. Rubriblast, rubricyte, metarubricyte, reticulocyte D. Rubriblast, metarubricyte, reticulocyte 161 / 209 Category: Hematology 161. Lymphocytic cell stains negative in which of the following stains? A. Myeloperoxidase (MPO) and Sudan black B B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS) C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains 162 / 209 Category: Hematology 162. Which of the following is the most commonly used routine stain for blood smear? A. Prussian blue B. Wright's stain C. Supravital stain D. New methylene Blue CD13, CD33 positive (myeloid) and CD14 positive (monocytes) 163 / 209 Category: Hematology 163. Which of the following cell markers is positive in acute myelomonocytic leukemia (AMML; FAB M4)? A. CD13, CD15, and CD33 B. CD13, CD33 positive and CD14 positive C. CD45 and CD71 164 / 209 Category: Hematology 164. What is this cell? A. Macrophages B. Monocytes C. Plasma cell D. Reactive Lymphocytes 165 / 209 Category: Hematology 165. Smudge cell is seen in which of the following malignancy? A. Chronic lymphocytic leukemia (CLL) B. Hairy cell leukemia (HCL) C. Acute lymphocytic leukemia (CLL) D. Chronic myelogenous leukemia (CML) 166 / 209 Category: Hematology 166. What is the structure of the hemoglobin molecule ? A. Two heme groups, two globin chains B. Four heme groups, two globin chains C. Four heme groups, four globin chains D. Two heme groups, four globin chains 167 / 209 Category: Hematology 167. What does the term “poikilocytosis” mean? A. Variations in size B. Variations in shape C. Variation of central palor D. Variations in color 168 / 209 Category: Hematology 168. Which of the following is not classified as a myeloproliferative disorder? A. Polycythemia vera B. Essential thrombocythemia C. Seizary Syndrome D. Chronic myelogenous leukemia 169 / 209 Category: Hematology 169. Antigen-dependent lymphopoiesis occurs in secondary lymphoid tissue located in A. Liver and spleen B. Spleen and kidney C. Peyer's patches and spleen D. Thymus and bone marrow 170 / 209 Category: Hematology 170. Basophilic stippling is composed of A. Vitamin K B. RNA C. Iron granules D. DNA 171 / 209 Category: Hematology 171. Which erythrocyte metabolic pathway generates NADPH ? A. Embden-Meyerhof B. Hexose monophosphate C. Rapoport-Luebering D. Methemoglobin reductase 172 / 209 Category: Hematology 172. Thalassemias are the result of a? A. Structural defect in the globin portion of hemoglobin B. Quantitative defect in globin-chain synthesis C. Qualitative defect in globin-chain structure D. Qualitative defect in heme structure 173 / 209 Category: Hematology 173. Which neutrophil abnormality is associated with Vitamin B12 deficiency? A. Hyposegmented neutrophil B. Hypersegmented neutrophil C. Enlarged neutrophils D. Bilobed neutrophil 174 / 209 Category: Hematology 174. What is this cell? A. Macrophages B. Monocytes C. Plasma cell D. Reactive Lymphocytes 175 / 209 Category: Hematology 175. What is this cell? A. Dacrocytes B. Schistocytes C. Echinocytes D. Acanthocytes 176 / 209 Category: Hematology 176. Which of the following protein stimulates red blood cell production? A. Erythropoietin B. Transferrin C. Hemopexin D. Prealbumin 177 / 209 Category: Hematology 177. Which of the following is the most commonly used routine stain for blood smear ? A. Prussian blue B. Supravital stain C. Wright's stain D. New methylene Blue 178 / 209 Category: Hematology 178. Which of the following test is used to measure bone marrow erythropoiesis? A. Hams Sugar test B. Erythrocyte Sedimentation Rate C. Reticulocyte count D. Cell count 179 / 209 Category: Hematology 179. Which of the following is a lipid storage disorder caused by deficiency in sphingomyelinase, associated with foamy bone marrow appearance ? A. Niemann-Pick disease B. Gaucher disease C. Alder normally D. Chronic granulomatous disease (CGD) 180 / 209 Category: Hematology 180. Which macrocytic anemia affects the Central Nervous System? A. Iron deficiency anemia B. Sideroblastic anemia C. Folate deficiency D. Vitamin B12 deficiency 181 / 209 Category: Hematology 181. Impaired DNA metabolism is characteristic of which type of anemia? A. Thalassemia B. Sideroblastic anemia C. Iron-deficiency anemia D. Megaloblastic anemia 182 / 209 Category: Hematology 182. What is a true increase in the number of lymphocytes called? A. Absolute lymphopenia B. Absolute lymphocytosis C. Relative lymphocytosis D. Absolute polycythemia 183 / 209 Category: Hematology 183. This rod is associated with acute promyelocytic leukemia(AML). Identify the cell? A. Howell Jolly Bodies B. Auer rods C. Plasma cell D. Reactive Lymphocytes 184 / 209 Category: Hematology 184. Which stain is used to enumerate reticulocytes ? A. New methylene blue B. Wright stain C. Grams stain D. Eosin stain 185 / 209 Category: Hematology 185. Which of the following is diagnostic of Multiple myeloma? A. "M"-spike in the gamma-globulin region in serum electrophoresis B. Bence Jones proteins in the urine C. Excessive production IgM (macroglobulin) D. production of excessive IgG (macroglobulin) E. A ,B and D 186 / 209 Category: Hematology 186. What is the MCH? Hemoglobin 14.1 g/dL RBC 4.12 x 10^12/L Hematocrit 41.3% A. 34.2pg B. 29.2pg C. 32.2pg D. 27.2pg 187 / 209 Category: Hematology 187. Auer rods will stain positive in which of the following stains? A. Myeloperoxidase (MPO) and Sudan black B B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS) C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains 188 / 209 Category: Hematology 188. Impaired DNA metabolism is characteristic of which type of anemia? A. Folic acid deficiency B. Iron deficiency anemia C. Sideroblastic anemia D. Lead poisoning 189 / 209 Category: Hematology 189. What structure do methylene blue stain? A. DNA B. RNA C. Hemoglobin D. DNA and RNA 190 / 209 Category: Hematology 190. Neutrophils with 5 or more lobes are called ? A. Multisegmented neutrophils B. Hypersegmented neutrophils C. Hyposegmented neutrophils D. Monosegmented neutrophils 191 / 209 Category: Hematology 191. In Waldenstrom macroglobulinemia which immunoglobin is increasingly produced? A. IgM B. IgG C. IgA D. IgS 192 / 209 Category: Hematology 192. Which hemoglobin forms are incapable of oxygen transport ? A. Deoxyhemoglobin and carboxyhemoglobin B. Methemoglobin and deoxyhemoglobin C. Oxyhemoglobin and deoxyhemoglobin D. Carboxyhemoglobin and methemoglobin 193 / 209 Category: Hematology 193. Which of the following is associated with a “shift to the right” in the oxygen dissociation curve of hemoglobin ? A. Decreased oxygen release B. Increased pH, high 2,3-bisphosphoglycerate and increased body temperature C. Decreased pH, high 2, 3-bisphosphoglycerate and elevated temperature D. Decreased carbon release 194 / 209 Category: Hematology 194. Impaired DNA metabolism is characteristic of which type of anemia? A. Iron deficiency anemia B. Sideroblastic anemia C. Lead poisoning D. Vitamin B12 deficiency 195 / 209 Category: Hematology 195. Which cell type is predominant in acute lymphoblastic leukemia? A. lymphoblasts B. myeloblasts C. granulocytes 196 / 209 Category: Hematology 196. What is the primary site of hematopoiesis in the third month of gestation? A. Spleen B. Marrow of long bones C. Liver D. Yolk sac 197 / 209 Category: Hematology 197. What is this cell? A. Basophilic stipplings B. Reticulocyte C. Washed red blood cells D. Artifact 198 / 209 Category: Hematology 198. What is the most common enzyme deficiency in Embden Meyerhof Pathway? A. G6PD (glucose-6-phosphate dehydrogenase) deficiency B. Hereditary spherocytosis C. Pyruvate kinase (PK) deficiency D. Paroxysmal nocturnal hemoglobinuria (PNH) 199 / 209 Category: Hematology 199. Which hemoglobin migrates with hemoglobins A2, C, and O on alkaline hemoglobin electropheroseis? A. Hgb F B. Hgb C C. Hgb SC D. Hgb E 200 / 209 Category: Hematology 200. Which test is used to differentiate chronic myelogenous leukemia (CML) from a neutrophilic leukemoid reaction (NLR)? A. Periodic acid-Schiff (PAS) B. Nonspecific esterase stains C. Sudan Black D. Leukocyte alkaline phosphatase (LAP) 201 / 209 Category: Hematology 201. Programmed cell death is called ? A. Cell biopsy B. Necrosis C. Gangrene D. Apoptosis 202 / 209 Category: Hematology 202. In what condition would an LAP score of 180 most likely be found? A. Bacterial septicemia B. paroxysmal nocturnal hemoglobinuria C. Polycythemia vera D. Polycythemia vera and Bacterial septicemia 203 / 209 Category: Hematology 203. An aggressive form of cutaneous T-cell lymphoma is? A. Sezary syndrome B. Mycosis fungoides C. Reed-Sternberg syndrome D. Chronic myelogenous leukemia (CML) 204 / 209 Category: Hematology 204. Which protein transports hemoglobin dimers resulting from intravascular hemolysis ? A. Hemopexin B. Albumin C. Haptoglobin D. Hemosiderin 205 / 209 Category: Hematology 205. Which inclusion is seen in G6PD (glucose-6-phosphate dehydrogenase) deficiency? A. Heinz bodies B. Ringed sideroblasts C. Howell jolly D. Pappenheimer bodies 206 / 209 Category: Hematology 206. Which of the following clinical finding is associated with Hgb SS disease? A. Bone marrow erythroid hyperplasia B. Decreased haptoglobin C. Positive hemoglobin solubility D. All of the above 207 / 209 Category: Hematology 207. What is this cell? A. Monocytes B. Eosinophils C. Lymphocytes D. Basophils 208 / 209 Category: Hematology 208. Which neutrophil abnormality is caused by MYH9 gene mutation, and characterized by the presence of Dohle-like bodies, giant platelets and thrombocytopenia? A. Pelger Huet Anomaly B. May-Hegglin anomaly C. Chediak-Higashi syndrome D. Chronic granulomatous disease (CGD) 209 / 209 Category: Hematology 209. A 25-year-old woman complains to his physician of extreme fatigue. Her CBC results are as follows: WBC 6.8 x 10^9/L RBC 3.9 x 10^12/L Hemoglobin 9.2 g/dL Hematocrit 30% MCV 77fl MCH 24 pg MCHC 31 g/dL Serum Iron Ferritin RDW TIBC Prussian blue stain Decreased Decreased Decreased Increased Absent iron stores The results of the CBC and iron studies, in this case, are most characteristic of? A. Iron deficiency B. Megaloblastic anemia C. Sideroblastic anemia D. Anemia of chronic disease Your score is LinkedIn Facebook Twitter VKontakte 0% Restart quiz Send feedback Share this: Share on X (Opens in new window) X Share on Facebook (Opens in new window) Facebook Like this:Like Loading...