Myeloproliferative and Lymphoproliferative Disorders

This 31 multiple choice quiz will test your knowledge of myeloproliferative and lymphoproliferative  leukemias. 

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Myeloproliferative and Lymphoproliferative Disorders

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Category: Hematology

1. Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

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Category: Hematology

2. Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia?

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Category: Hematology

3. Which chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

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Category: Hematology

4. Which lymphoma has Reed-Sternberg cells?

CD13, CD33 positive (myeloid) and CD14 positive (monocytes)

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Category: Hematology

5. Which of the following cell markers is positive in acute myelomonocytic leukemia (AMML; FAB M4)?

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Category: Hematology

6. Which malignant disorder is associated with left shift with myelocytes the predominate cell?

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Category: Hematology

7. What is the genetic translocation for FAB M2 (AML with maturation)?

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Category: Hematology

8. Which of the following is not classified as a myeloproliferative disorder?

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Category: Hematology

9. Which gene mutation is implicated in Essential thrombocythemia (ET)?

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Category: Hematology

10. Increased LAP score is seen in?

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Category: Hematology

11. What is the genetic translocation in FAB L3/Burkitt lymphoma?

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Category: Hematology

12. In what condition would an LAP score of 10 most likely be found?

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Category: Hematology

13. Chronic myeloproliferative disorders terminate in?

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Category: Hematology

14. Which leukemia is characterized by a proliferation of megakaryoblasts and positivity for CD41, CD42, and CD61 by flow cytometry?

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Category: Hematology

15. Which of the following cell markers are seen in B cell malignancy?

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Category: Hematology

16. The presence of the chromosomal abnormality t(15;17) with disseminated intravascular coagulation (DIC) is diagnostic of?

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Category: Hematology

17. Which gene mutation is implicated in polycythemia?

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Category: Hematology

18. Which test is used to differentiate chronic myelogenous leukemia (CML) from a neutrophilic leukemoid reaction (NLR)?

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Category: Hematology

19. Which of the following is diagnostic of Multiple myeloma?

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Category: Hematology

20. An aggressive form of cutaneous T-cell lymphoma is?

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Category: Hematology

21. Which of the following stain is used in the diagnosis of Hairy cell leukemia?

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Category: Hematology

22. Di Guglielmo syndrome is also classified as?

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Category: Hematology

23.  Burkitt lymphoma is associated with which of the following virus?

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Category: Hematology

24. What is the genetic translocation in chronic myelogenous leukemia (CML)?

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Category: Hematology

25.  Which malignant disorder is characterized by the presence of oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia and abnormal morphology associated with all cell lines ?

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Category: Hematology

26. Which gene mutation is associated with chronic myelogenous leukemia?

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Category: Hematology

27. Smudge cell is seen in which of the following malignancy?

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Category: Hematology

28. In what condition would an LAP score of 180 most likely be found?

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Category: Hematology

29. In Waldenstrom macroglobulinemia which immunoglobin is increasingly produced?

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Category: Hematology

30. A cutaneous lymphoma that causes skin itching and ulcerative tumor are called?

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Category: Hematology

31. Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

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Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

t(15;17)

Which of the following stain is used in the diagnosis of hairy cell leukemia?

Tartrate-resistant acid phosphatase stain (TRAP)

Smudge cell is seen in which of the following malignancy?

Chronic lymphocytic leukemia (CLL)

Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia?

Hairy cell leukemia (HCL)

Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

Reed-Sternberg cells

A cutaneous lymphoma that causes skin itching and ulcerative tumors are called

Mycosis fungoides

Which gene mutation is implicated in polycythemia?

JAK2 oncogene

 Which malignant disorder is characterized by anisocytosis, oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia, and abnormal morphology associated with all cell lines?

Myelodysplastic Syndromes (MDS)

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