Myeloproliferative and Lymphoproliferative Disorders

This 31 multiple choice quiz will test your knowledge of myeloproliferative and lymphoproliferative  leukemias. 

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Myeloproliferative and Lymphoproliferative Disorders

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Category: Hematology

1. Di Guglielmo syndrome is also classified as?

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Category: Hematology

2. Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

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Category: Hematology

3. Which leukemia is characterized by a proliferation of megakaryoblasts and positivity for CD41, CD42, and CD61 by flow cytometry?

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Category: Hematology

4. Which gene mutation is implicated in Essential thrombocythemia (ET)?

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Category: Hematology

5. Which gene mutation is implicated in polycythemia?

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Category: Hematology

6. Increased LAP score is seen in?

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Category: Hematology

7. In what condition would an LAP score of 180 most likely be found?

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Category: Hematology

8. In what condition would an LAP score of 10 most likely be found?

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Category: Hematology

9. Smudge cell is seen in which of the following malignancy?

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Category: Hematology

10.  Which malignant disorder is characterized by the presence of oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia and abnormal morphology associated with all cell lines ?

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Category: Hematology

11. Which of the following is diagnostic of Multiple myeloma?

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Category: Hematology

12. Which lymphoma has Reed-Sternberg cells?

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Category: Hematology

13. Which of the following cell markers are seen in B cell malignancy?

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Category: Hematology

14. Which malignant disorder is associated with left shift with myelocytes the predominate cell?

CD13, CD33 positive (myeloid) and CD14 positive (monocytes)

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Category: Hematology

15. Which of the following cell markers is positive in acute myelomonocytic leukemia (AMML; FAB M4)?

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Category: Hematology

16. In Waldenstrom macroglobulinemia which immunoglobin is increasingly produced?

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Category: Hematology

17. A cutaneous lymphoma that causes skin itching and ulcerative tumor are called?

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Category: Hematology

18. An aggressive form of cutaneous T-cell lymphoma is?

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Category: Hematology

19. Chronic myeloproliferative disorders terminate in?

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Category: Hematology

20. Which of the following stain is used in the diagnosis of Hairy cell leukemia?

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Category: Hematology

21. Which gene mutation is associated with chronic myelogenous leukemia?

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Category: Hematology

22.  Burkitt lymphoma is associated with which of the following virus?

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Category: Hematology

23. Which chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

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Category: Hematology

24. The presence of the chromosomal abnormality t(15;17) with disseminated intravascular coagulation (DIC) is diagnostic of?

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Category: Hematology

25. What is the genetic translocation for FAB M2 (AML with maturation)?

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Category: Hematology

26. Which of the following is not classified as a myeloproliferative disorder?

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Category: Hematology

27. Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia?

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Category: Hematology

28. What is the genetic translocation in FAB L3/Burkitt lymphoma?

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Category: Hematology

29. Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

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Category: Hematology

30. What is the genetic translocation in chronic myelogenous leukemia (CML)?

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Category: Hematology

31. Which test is used to differentiate chronic myelogenous leukemia (CML) from a neutrophilic leukemoid reaction (NLR)?

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Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

t(15;17)

Which of the following stain is used in the diagnosis of hairy cell leukemia?

Tartrate-resistant acid phosphatase stain (TRAP)

Smudge cell is seen in which of the following malignancy?

Chronic lymphocytic leukemia (CLL)

Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia?

Hairy cell leukemia (HCL)

Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

Reed-Sternberg cells

A cutaneous lymphoma that causes skin itching and ulcerative tumors are called

Mycosis fungoides

Which gene mutation is implicated in polycythemia?

JAK2 oncogene

 Which malignant disorder is characterized by anisocytosis, oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia, and abnormal morphology associated with all cell lines?

Myelodysplastic Syndromes (MDS)

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