Myeloproliferative and Lymphoproliferative Disorders

This 31 multiple choice quiz will test your knowledge of myeloproliferative and lymphoproliferative  leukemias. 

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Myeloproliferative and Lymphoproliferative Disorders

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Category: Hematology

1. Which test is used to differentiate chronic myelogenous leukemia (CML) from a neutrophilic leukemoid reaction (NLR)?

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Category: Hematology

2. What is the genetic translocation in chronic myelogenous leukemia (CML)?

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Category: Hematology

3. Which of the following stain is used in the diagnosis of Hairy cell leukemia?

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Category: Hematology

4. Chronic myeloproliferative disorders terminate in?

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Category: Hematology

5. Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

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Category: Hematology

6.  Which malignant disorder is characterized by the presence of oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia and abnormal morphology associated with all cell lines ?

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Category: Hematology

7. Di Guglielmo syndrome is also classified as?

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Category: Hematology

8. What is the genetic translocation for FAB M2 (AML with maturation)?

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Category: Hematology

9. Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

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Category: Hematology

10. In what condition would an LAP score of 10 most likely be found?

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Category: Hematology

11. Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia?

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Category: Hematology

12. Which of the following is not classified as a myeloproliferative disorder?

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Category: Hematology

13. An aggressive form of cutaneous T-cell lymphoma is?

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Category: Hematology

14. The presence of the chromosomal abnormality t(15;17) with disseminated intravascular coagulation (DIC) is diagnostic of?

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Category: Hematology

15. Which of the following is diagnostic of Multiple myeloma?

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Category: Hematology

16. A cutaneous lymphoma that causes skin itching and ulcerative tumor are called?

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Category: Hematology

17. In what condition would an LAP score of 180 most likely be found?

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Category: Hematology

18. What is the genetic translocation in FAB L3/Burkitt lymphoma?

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Category: Hematology

19. Which gene mutation is implicated in Essential thrombocythemia (ET)?

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Category: Hematology

20. Which leukemia is characterized by a proliferation of megakaryoblasts and positivity for CD41, CD42, and CD61 by flow cytometry?

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Category: Hematology

21. In Waldenstrom macroglobulinemia which immunoglobin is increasingly produced?

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Category: Hematology

22. Which of the following cell markers are seen in B cell malignancy?

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Category: Hematology

23. Increased LAP score is seen in?

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Category: Hematology

24. Which lymphoma has Reed-Sternberg cells?

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Category: Hematology

25. Which gene mutation is associated with chronic myelogenous leukemia?

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Category: Hematology

26.  Burkitt lymphoma is associated with which of the following virus?

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Category: Hematology

27. Which chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

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Category: Hematology

28. Smudge cell is seen in which of the following malignancy?

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Category: Hematology

29. Which gene mutation is implicated in polycythemia?

CD13, CD33 positive (myeloid) and CD14 positive (monocytes)

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Category: Hematology

30. Which of the following cell markers is positive in acute myelomonocytic leukemia (AMML; FAB M4)?

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Category: Hematology

31. Which malignant disorder is associated with left shift with myelocytes the predominate cell?

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Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

t(15;17)

Which of the following stain is used in the diagnosis of hairy cell leukemia?

Tartrate-resistant acid phosphatase stain (TRAP)

Smudge cell is seen in which of the following malignancy?

Chronic lymphocytic leukemia (CLL)

Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia?

Hairy cell leukemia (HCL)

Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

Reed-Sternberg cells

A cutaneous lymphoma that causes skin itching and ulcerative tumors are called

Mycosis fungoides

Which gene mutation is implicated in polycythemia?

JAK2 oncogene

 Which malignant disorder is characterized by anisocytosis, oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia, and abnormal morphology associated with all cell lines?

Myelodysplastic Syndromes (MDS)

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