Hematology Test Bank -

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Hematology Question Bank

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Category: Hematology

1. A 27-year-old woman complains to his physician of pain and fatigue. Her results are as follows:

WBC 5.4 x 10^9/L

RBC 3.9 x 10^12/L

Hemoglobin 8.2 g/dL

Hematocrit 28%

MCV 72 fL

MCHC 29.3 g/dL

ESR increased

Serum iron and total iron-binding capacity (TIBC) both decreased

Serum ferritin slightly elevated.

Presence of Prussian-blue-stainable iron in bone marrow was also noted.

Based her laboratory result, what is the cause of anemia?

A. Sideroblastic anemia

B. Anemia of Chronic Inflammation

C. Iron-deficiency anemia

D. Megaloblastic anemia

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Category: Hematology

2. Which of the following is a lipid storage disorder caused by deficiency in glucocerebrosidase

A. Niemann-Pick disease

B. Gaucher disease

C. Alder normally

D. Chronic granulomatous disease (CGD)

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Category: Hematology

3. Diphyllobothrium latum is associated with the development of?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Lead poisoning

D. Vitamin B12 deficiency

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Category: Hematology

4. What is the average lifespan of a normal red blood cell ?

A. 90 days

B. 180 days

C. 120 days

D. 60 days

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Category: Hematology

5. Impaired DNA metabolism is characteristic of which type of anemia ?

A. Thalassemia

B. Sideroblastic anemia

C. Megaloblastic anemia

D. Iron-deficiency anemia

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Category: Hematology

6. What is the MCV?


Hemoglobin	14.1 g/dL
RBC	4.12 x 10^12/L
Hematocrit	41.3%

A. 104fL

B. 79fL

C. 100.2fL

D. 99fL

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Category: Hematology

7. Defective hemoglobin synthesis due to a block in the protoporphyrin pathway will result in which type of anemia?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

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Category: Hematology

8. Hemoglobinopathies are inherited disorders caused by

A. Amino acid substitutions

B. Block in NADPH

C. Abnormal Hemoglobin structure

D. Peptide mutation

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Category: Hematology

9. In Waldenstrom macroglobulinemia which immunoglobin is increasingly produced?

A. IgM

B. IgG

C. IgA

D. IgS

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Category: Hematology

10. Which of the following is a true red cell aplasia?

A. Diamond-Blackfan anemia

B. Fanconi anemia

C. Sideroblastic anemia

D. Aplasia

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Category: Hematology

11. What are the stages of granulocyte development ?

A. Myeloblast, Promyelocyte, Myelocyte, Metamyelocyte, band neutrophils

B. Myeloblast, Myelocyte, Promyelocyte, Metamyelocyte, band neutrophils

C. Myeloblast, Myelocyte, Metamyelocyte, Promyelocyte, band neutrophils

D. Myeloblast, Myelocyte, Metamyelocyte, band neutrophils

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Category: Hematology

12. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia?

A. Low Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

B. High Leukocyte Alkaline Phosphatase (LAP) score in chronic myelogenous leukemia

C. High Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

D. Philadelphia chromosome, t (9; 22) score in leukemoid reaction

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Category: Hematology

13. Deficiency of intrinsic factors causes?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Lead poisoning

D. Pernicious anemia

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Category: Hematology

14. Which hemoglobin migrates with Hgb S and Hgb G on alkaline hemoglobin electrophoresis?

A. Hgb F

B. Hgb C

C. Hgb D

D. Hgb SC

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Category: Hematology

15. What is the MCH?


Hemoglobin	14.9 g/dL
RBC	4.84 x 10^12/L
Hematocrit	44.4%

A. 30.8pg

B. 34pg

C. 36pg

D. 29pg

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Category: Hematology

16. Which of the following conditions is most commonly associated with pica?

A. Anemia of chronic inflammation

B. Alpha thalassemia

C. Iron deficiency

D. Lead poisoning

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Category: Hematology

17. World Health Organization (WHO) defines acute leukemia as?

A. >20% bone marrow blasts.

B. >30% bone marrow blasts.

C. >70% bone marrow blasts.

D. >50% bone marrow blasts.

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Category: Hematology

18. Blood loss caused by gastrointestinal bleeding is classified as

A. Chronic blood loss

B. Reticulocytosis

C. Acute blood loss

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Category: Hematology

19. Which abnormal red blood cell is seen in abetalipoproteinemia?

A. Spherocytes

B. Acanthocytes

C. Echinocytes

D. Codocytes

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Category: Hematology

20. French-American-British (FAB) defines acute leukemia as?

A. >20% bone marrow blasts.

B. >30% bone marrow blasts.

C. >70% bone marrow blasts.

D. >50% bone marrow blasts.

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Category: Hematology

21. Which of the following is associated with a "shift to the right" in the oxygen dissociation curve of hemoglobin ?

A. Decreased oxygen release

B. Increased pH, high 2,3-bisphosphoglycerate and increased body temperature

C. Decreased pH, high 2, 3-bisphosphoglycerate and elevated temperature

D. Decreased carbon release

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Category: Hematology

22. What is the structure of the hemoglobin molecule ?

A. Two heme groups, two globin chains

B. Four heme groups, two globin chains

C. Four heme groups, four globin chains

D. Two heme groups, four globin chains

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Category: Hematology

23. Which gene mutation is implicated in polycythemia?

A. JAK2 oncogene

B. t(8;11)

C. BCR/ABL oncogene

D. t(11;17)

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Category: Hematology

24. What is a true increase in the number of lymphocytes called ?

A. Absolute lymphocytosis

B. Absolute lymphopenia

C. Relative lymphocytosis

D. Absolute polycythemia

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Category: Hematology

25. Which classification for hematopoietic malignancy is the accepted standard for diagnosis?

A. French-American-British (FAB)

B. World Health Organization (WHO)

C. Cancer Association Method

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Category: Hematology

26. Hemoglobin F consists of ?

A. Two alpha- and two beta-globin chains

B. Two alpha- and two gamma-globin chains

C. Two alpha- and two delta-globin chains

D. Four alpha- and two beta-globin chains

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Category: Hematology

27. Pancytopenia is seen in which type of anemia?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Aplastic anemia

D. Anemia of chronic inflammation

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Category: Hematology

28. What structures do methylene blue stain?

A. DNA

B. RNA

C. Hemoglobin

D. DNA and RNA

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Category: Hematology

29. Which inclusion is seen in G6PD (glucose-6-phosphate dehydrogenase) deficiency?

A. Heinz bodies

B. Ringed sideroblasts

C. Howell jolly

D. Pappenheimer bodies

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Category: Hematology

30. Which of the following anemia is associated with dwarfism and mental retardation?

A. Diamond-Blackfan anemia

B. Fanconi anemia

C. Sideroblastic anemia

D. Aplasia

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Category: Hematology

31. Which gene mutation is associated with chronic myelogenous leukemia?

A. JAK2 oncogene

B. t(8;11)

C. t(8;14)

D. BCR/ABL oncogene

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Category: Hematology

32. The presence of the chromosomal abnormality t(15;17) with disseminated intravascular coagulation (DIC) is diagnostic of?

A. Acute myeloblastic leukemia without maturation (FAB type Ml)

B. Acute myeloblastic leukemia with maturation (FAB type M2)

C. Acute promyelocytic leukemia (FAB type M3)

D. Acute myelomonocytic leukemia (FAB type M4)

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Category: Hematology

33. Howell-Jolly bodies are composed of

A. Vitamin K

B. RNA

C. Iron granules

D. DNA

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Category: Hematology

34. What is the MCHC?


Hemoglobin	14.1 g/dL
RBC	4.12 x 10^12/L
Hematocrit	41.3%

A. 34.2g/dL

B. 34.1g/dL

C. 32.2g/dL

D. 27.2g/dL

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Category: Hematology

35. Impaired DNA metabolism is characteristic of which type of anemia?

A. Folic acid deficiency

B. Iron deficiency anemia

C. Sideroblastic anemia

D. Lead poisoning

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Category: Hematology

36. Which of the following stains is used in distinguishing acute leukemias of myeloid origin from the monocytic origin?

A. Myeloperoxidase (MPO)

B. Periodic acid-Schiff (PAS)

C. Nonspecific esterase stains

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Category: Hematology

37. Which lymphoma has Reed-Sternberg cells?

A. Hodgkin lymphoma

B. Non-Hodgkin lymphoma

C. Acute lymphocytic leukemia (CLL)

D. Chronic myelogenous leukemia (CML)

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Category: Hematology

38. Di Guglielmo syndrome is also classified as?

A. Acute megakaryocytic leukemia (AMegL; FAB M7)

B. Acute erythroleukemia; FAB M6

C. Acute myelomonocytic leukemia ;AMML; FAB M4

D. Acute promyelocytic leukemia (APL); FAB M3

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Category: Hematology

39. What is this cell?

A. Dacrocytes

B. Reticulocyte

C. Codocytes

D. Elliptocytes

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Category: Hematology

40. Increased LAP score is seen in?

A. Chronic myelogenous leukemia (CML)

B. Paroxysmal nocturnal hemoglobinuria

C. Neutrophilic leukemoid reaction

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Category: Hematology

41. What structure do methylene blue stain?

A. DNA

B. RNA

C. Hemoglobin

D. DNA and RNA

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Category: Hematology

42. Which chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

A. t(15;17)

B. t(8;11)

C. t(8;14)

D. t(11;17)

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Category: Hematology

43. Which type of hemoglobin is produced in the mesoblastic phase?

A. Portland

B. Hgb F

C. Hgb A

D. Portland, Gower I and Gower II

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Category: Hematology

44. What is the MCH?


Hemoglobin	11.1 g/dL
RBC	3.65 x 10^12/L
Hematocrit	32.5%

A. 31pg

B. 33 pg

C. 30.9pg

D. 30.4pg

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Category: Hematology

45. What is this cell?

A. Monocytes

B. Eosinophils

C. Lymphocytes

D. Basophils

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Category: Hematology

46. Basophilia is associated with?

A. Type I hypersensitivity reactions

B. Leukemoid reaction (NLR)

C. Chronic myelogenous leukemia

D. Type I hypersensitivity reactions and chronic myelogenous leukemia

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Category: Hematology

47. What is the pH of blood?

A. 7.25-7.45

B. 7.30-7.45

C. 7.32-7.49

D. 7.35-7.45

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Category: Hematology

48. Which neutrophil abnormality is caused by mutation in Lamin B receptor and characterized by the presence of bilobed neutrophils ?

A. Pelger Huet Anomaly

B. Chediak-Higashi syndrome

C. May-Hegglin anomaly

D. Chronic granulomatous disease (CGD)

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Category: Hematology

49. What does the term "anisocytosis" mean?

A. Variations in size

B. Variations in shape

C. Variation of central palor

D. Variations in color

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Category: Hematology

50. In what condition would an LAP score of 180 most likely be found?

A. Bacterial septicemia

B. paroxysmal nocturnal hemoglobinuria

C. Polycythemia vera

D. Polycythemia vera and Bacterial septicemia

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Category: Hematology

51. Hgb C Disease/Hgb CC is caused by substitution of glutamic acid with..

A. Lysine

B. Valine

C. Leucine

D. Glycine

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Category: Hematology

52. Adult hemoglobin consists of ?

A. Hgb F contains two alpha- and four beta-globin chains

B. Hgb A contains four alpha- and two beta-globin chains

C. Hgb A contains two alpha- and two beta-globin chains

D. Hgb F contains three alpha- and four beta-globin chains

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Category: Hematology

53. Which of the following differentiates non-megaloblastic macrocytic anemias from megaloblastic anemias?

A. Oval erythrocytes in non-megaloblastic macrocytic

B. Round erythrocytes in megaloblastic anemias

C. Hypersegmented neutrophil in non-megaloblastic macrocytic

D. Round erythrocytes in non-megaloblastic macrocytic

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Category: Hematology

54. A 25-year-old woman complains to his physician of extreme fatigue. Her CBC results are as follows:


WBC	6.8 x 10^9/L
RBC	3.9 x 10^12/L
Hemoglobin	9.2 g/dL
Hematocrit	30%
MCV	77fl
MCH	24 pg
MCHC	31 g/dL

Serum Iron	Ferritin	RDW	TIBC	Prussian blue stain
Decreased	Decreased	Decreased	Increased	Absent iron stores

The results of the CBC and iron studies, in this case, are most characteristic of?

A. Iron deficiency

B. Megaloblastic anemia

C. Sideroblastic anemia

D. Anemia of chronic disease

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Category: Hematology

55. Lymphocytic cell stains negative in which of the following stains?

A. Myeloperoxidase (MPO) and Sudan black B

B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS)

C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains

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Category: Hematology

56. What is the pH of blood ?

A. 7.35-7.45

B. 7.25-7.45

C. 7.30-7.45

D. 7.32-7.49

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Category: Hematology

57. Which of the following stain is used to visualize iron granules in RBCs ?

A. Wright's stain

B. Supravital stain

C. New methylene Blue

D. Prussian blue

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Category: Hematology

58. Which of the following stain is used in the diagnosis of Hairy cell leukemia?

A. Periodic acid-Schiff (PAS)

B. Nonspecific esterase stains

C. Sudan Black

D. Tartrate-resistant acid phosphatase stain (TRAP)

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Category: Hematology

59. Programmed cell death is called ?

A. Cell biopsy

B. Necrosis

C. Gangrene

D. Apoptosis

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Category: Hematology

60. Which neutrophil abnormality is associated with Vitamin B12 deficiency?

A. Hyposegmented neutrophil

B. Hypersegmented neutrophil

C. Enlarged neutrophils

D. Bilobed neutrophil

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Category: Hematology

61. What does Wright's stain consist of?

A. Methylene blue and cresyl green

B. Methylene blue and eosin

C. Methylene blue and neutral red

D. Methylene blue and Giemsa stain

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Category: Hematology

62. Which of the following characterizes sideroblastic anemia?

A. Serum iron decreased, transferrin decreased

B. Serum iron decreased, transferrin increased

C. Serum iron normal, transferrin normal

D. TIBC decreased, increased ferritin and serum iron

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Category: Hematology

63. Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

A. t(15;17); PML/RARA oncogene

B. t(8;11)

C. t(8;14)

D. t(11;17)

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Category: Hematology

64. What is the first type of blood cell produced by the developing embryo?

A. Thrombocyte

B. Granulocyte

C. Lymphocytes

D. Erythrocytes

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Category: Hematology

65. Which of the following cell markers are seen in B cell malignancy?

A. CD19, and CD20 positive

B. CD2, and CD4 positive

C. CD2, CD19, and CD20 positive

D. CD4, CD19, and CD20 positive

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Category: Hematology

66. Smudge cell is seen in which of the following malignancy?

A. Chronic lymphocytic leukemia (CLL)

B. Hairy cell leukemia (HCL)

C. Acute lymphocytic leukemia (CLL)

D. Chronic myelogenous leukemia (CML)

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Category: Hematology

67. Which of the following protein stimulates red blood cell production?

A. Erythropoietin

B. Transferrin

C. Hemopexin

D. Prealbumin

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Category: Hematology

68. Which macrocytic anemia affects the Central Nervous System?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Folate deficiency

D. Vitamin B12 deficiency

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Category: Hematology

69. Which of the following red blood cell morphology abnormalities is associated hemoglobinopathies?

A. Ovalocytes

B. Target cells

C. Echinocytes

D. Acanthocytes

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Category: Hematology

70. Which of the following characterizes Vitamin B12 deficiency Anemia?

A. Decreased methylmalonic acid (MMA), Increased homocysteine

B. Increased methylmalonic acid (MMA), Increased homocysteine

C. Decreased methylmalonic acid (MMA), Decreased homocysteine

D. Decreased methylmalonic acid (MMA), Increased homocysteine

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Category: Hematology

71. Which of the following is the most common cause of iron deficiency?

A. Bleeding

B. Increased need

C. Inadequate diet

D. Pregnancy

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Category: Hematology

72. What is the genetic translocation for FAB M2 (AML with maturation)?

A. t(15;17)

B. t(8;21)

C. t(8;14)

D. t(11;17)

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Category: Hematology

73. A sudden loss of blood from traumatic injuries is..

A. Chronic blood loss

B. Reticulocytosis

C. Acute blood loss

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Category: Hematology

74. Decrease in absolute number of neutrophils is called ?

A. Eosinophilia

B. Leukopenia

C. Neutropenia

D. Leukocytosis

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Category: Hematology

75. What is the major storage form of iron?

A. Transferrin

B. Hemosiderin

C. Ferritin

D. Hemachromatin

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Category: Hematology

76. What is the MCV?


Hemoglobin	14.9 g/dL
RBC	4.84 x 10^12/L
Hematocrit	44.4%

A. 104fL

B. 79fL

C. 91.7fl

D. 99fL

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Category: Hematology

77. What hemoglobin is predominant at birth ?

A. Portland

B. Hgb F

C. Gower I

D. Gower II

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Category: Hematology

78. A neutrophil disorder caused by mutations in the LYST gene and associated oculocutaneous albinism is ?

A. Pelger Huet Anomaly

B. Chediak-Higashi syndrome

C. May-Hegglin anomaly

D. Chronic granulomatous disease (CGD)

79 / 210

Category: Hematology

79. What does Wright's stain consist of ?

A. Methylene blue and cresyl green

B. Methylene blue and neutral red

C. Methylene blue and eosin

D. Methylene blue and Giemsa stain

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Category: Hematology

80. Which stain is used to enumerate reticulocytes ?

A. New methylene blue

B. Wright stain

C. Grams stain

D. Eosin stain

81 / 210

Category: Hematology

81. Impaired DNA metabolism is characteristic of which type of anemia?

A. Iron deficiency anemia

B. Sideroblastic anemia

C. Lead poisoning

D. Vitamin B12 deficiency

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Category: Hematology

82. Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

A. Reed-Sternberg cells

B. Mycosis fungoides

C. Sezary syndrome

D. Smudge cells

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Category: Hematology

83. What does the term "poikilocytosis" mean?

A. Variations in size

B. Variations in shape

C. Variation of central palor

D. Variations in color

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Category: Hematology

84. What is the MCV?


Hemoglobin	11.1 g/dL
RBC	3.65 x 10^12/L
Hematocrit	32.5%

A. 84fL

B. 79fL

C. 89fL

D. 92fL

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Category: Hematology

85. Which stain is used for reticulocyte count ?

A. Wright's stain

B. Supravital stain

C. New methylene Blue

D. Prussian blue

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Category: Hematology

86. Pappenheimer bodies are composed of ?

A. Vitamin K

B. RNA

C. Iron granules

D. DNA

87 / 210

Category: Hematology

87. The most common cause of aplastic anemia is?

A. Idiopathic

B. Diamond-Blackfan anemia

C. Fanconi anemia

D. Sideroblastic anemia

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Category: Hematology

88. Which of the following test is used to measure bone marrow erythropoiesis?

A. Hams Sugar test

B. Erythrocyte Sedimentation Rate

C. Reticulocyte count

D. Cell count

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Category: Hematology

89. Which of the following test is used to measure bone marrow erythropoiesis?

A. Hams Sugar test

B. Reticulocyte count

C. Erythrocyte Sedimentation Rate

D. Cell count

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Category: Hematology

90. Which erythrocyte metabolic pathway generates 2,3-bisphosphoglycerate ?

A. Embden-Meyerhof

B. Hexose monophosphate

C. Rapoport-Luebering

D. Methemoglobin reductase

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Category: Hematology

91. Which type of anemia would you see ringed sideroblasts?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

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Category: Hematology

92. Which of the following stain is used to visualize iron granules in RBCs?

A. Prussian blue

B. Wright's stain

C. Supravital stain

D. New methylene Blue

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Category: Hematology

93. Which cell type is predominant in acute lymphoblastic leukemia?

A. lymphoblasts

B. myeloblasts

C. granulocytes

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Category: Hematology

94. What red cell morphologic abnormality has evenly spaced round projections and is associated with pyruvate kinase deficiency

A. Spherocytes

B. Echinocytes

C. Dacrocytes

D. Acanthocytes

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Category: Hematology

95. Senescent RBCs are phagocytized by macrophages in the liver or spleen and removed through

A. Extravascular hemolysis

B. Intravascular hemolysis

C. Necrosis

D. Cell degeneration

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Category: Hematology

96. Which protein transports hemoglobin dimers resulting from intravascular hemolysis ?

A. Hemopexin

B. Albumin

C. Haptoglobin

D. Hemosiderin

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Category: Hematology

97. What is the MCH?


Hemoglobin	14.1 g/dL
RBC	4.12 x 10^12/L
Hematocrit	41.3%

A. 34.2pg

B. 29.2pg

C. 32.2pg

D. 27.2pg

98 / 210

Category: Hematology

98. Which stain is useful in the diagnosis of erythroleukemia (FAB M6) and acute lymphoblastic leukemia?

A. Myeloperoxidase (MPO)

B. Periodic acid-Schiff (PAS)

C. Nonspecific esterase stains

D. Sudan Black

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Category: Hematology

99. Serum ferritin is an indirect measurement of

A. Tissue iron

B. Storage iron

C. Hemoglobin iron

D. Transferrin iron

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Category: Hematology

100. Which classification is based on cellular morphology and cytochemical stain results?

A. French-American-British (FAB)

B. World Health Organization (WHO)

C. Cancer Association Method

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Category: Hematology

101. Which of the following is not classified as a myeloproliferative disorder?

A. Polycythemia vera

B. Essential thrombocythemia

C. Seizary Syndrome

D. Chronic myelogenous leukemia

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Category: Hematology

102. Which of the following acquired hemolytic disorder causes intravascular hemolysis, presents with thrombocytopenia and schistocytes in peripheral blood smear?

A. Microangiopathic hemolytic anemias (MAHAs)

B. Paroxysmal nocturnal hemoglobinuria (PNH)

C. Hemolytic uremic syndrome (HUS)

D. Thrombotic thrombocytopenic purpura (TTP)

E. All of the above

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Category: Hematology

103. What is the primary site for pre-B cell differentiation ?

A. Liver

B. Spleen

C. Thymus

D. Bone marrow

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Category: Hematology

104. What is a true increase in the number of lymphocytes called?

A. Absolute lymphopenia

B. Absolute lymphocytosis

C. Relative lymphocytosis

D. Absolute polycythemia

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Category: Hematology

105. What is this cell?

A. Dacrocytes

B. Reticulocyte

C. Target cells

D. Elliptocytes

106 / 210

Category: Hematology

106. What is the primary site of hematopoiesis in the fifth month of gestation?

A. Spleen

B. Marrow of long bones

C. Liver

D. Yolk sac

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Category: Hematology

107. What is the normal ratio of myeloid to erythroid precursors in the bone marrow (M:E ratio)?

A. 2:1

B. 3:1

C. 5:1

D. 1:1

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Category: Hematology

108. Which of the following is the most commonly used routine stain for blood smear ?

A. Prussian blue

B. Supravital stain

C. Wright's stain

D. New methylene Blue

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Category: Hematology

109. A 21-year-old woman complains to his physician of fatigue, dizziness, and craving for ice. Her results are as follows:

Based on her laboratory result, what is the cause of anemia?

WBC 4.8 x 10^9/L

RBC 3.75 x 10^12/L

Hemoglobin 9.8 g/dL

Hematocrit 29%

MCV 77.3 fL

MCHC 33.8 g/dL

Serum iron and ferritin is decreased

Elevated total iron-binding capacity (TIBC)

Blood smear shows microcytic hypochromic red blood cells

A. Anemia of Chronic Inflammation

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

110 / 210

Category: Hematology

110. Antigen-independent lymphopoiesis occurs in

A. Liver and spleen

B. Spleen and kidney

C. Peyer's patches and spleen

D. Thymus and bone marrow

111 / 210

Category: Hematology

111. What is this cell?

A. Dacrocytes

B. Schistocytes

C. Echinocytes

D. Acanthocytes

112 / 210

Category: Hematology

112. What is the oxidation state of iron in Hemoglobin ?

A. Oxide state

B. Ferrous state

C. Peroxide state

D. Ferric state

CD13, CD33 positive (myeloid) and CD14 positive (monocytes)

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Category: Hematology

113. Which of the following cell markers is positive in acute myelomonocytic leukemia (AMML; FAB M4)?

A. CD13, CD15, and CD33

B. CD13, CD33 positive and CD14 positive

C. CD45 and CD71

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Category: Hematology

114. What is the primary site of hematopoiesis in the first month of gestation?

A. Spleen

B. Marrow of long bones

C. Liver

D. Yolk sac

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Category: Hematology

115. Which hemolytic anemia occurs most often in children following E. coli infection?

A. Paroxysmal nocturnal hemoglobinuria (PNH)

B. Hemolytic uremic syndrome (HUS)

C. Microangiopathic hemolytic anemias (MAHAs)

D. Thrombotic thrombocytopenic purpura (TTP)

116 / 210

Category: Hematology

116. What is this cell multi-lobed cells called?

A. Lymphocytes

B. Segmented Neutrophils

C. Monocytes

D. Eosinophils

117 / 210

Category: Hematology

117. Which of the following inclusions is only visible with supravital stain?

A. Dohle bodies

B. Pappenheimer bodies

C. Basophilic stippling

D. Heinz bodies

118 / 210

Category: Hematology

118. Decreased haptoglobin is indicative of

A. Extravascular hemolysis

B. Intravascular hemolysis

C. Intramedullary hematopoiesis

D. Intermedullary hematopoiesis

119 / 210

Category: Hematology

119. Neutrophils with 5 or more lobes are called ?

A. Multisegmented neutrophils

B. Hypersegmented neutrophils

C. Hyposegmented neutrophils

D. Monosegmented neutrophils

120 / 210

Category: Hematology

120. Which of the following is used to differentiate leukemoid reaction from chronic myelogenous leukemia ?

A. Low Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

B. High Leukocyte Alkaline Phosphatase (LAP) score in chronic myelogenous leukemia

C. High Leukocyte Alkaline Phosphatase (LAP) score in leukemoid reaction

D. Philadelphia chromosome, t (9; 22) score in leukemoid reaction

121 / 210

Category: Hematology

121. Which of the following clinical finding is associated with Hgb SS disease?

A. Bone marrow erythroid hyperplasia

B. Decreased haptoglobin

C. Positive hemoglobin solubility

D. All of the above

122 / 210

Category: Hematology

122. Chronic myeloproliferative disorders terminate in?

A. Acute leukemia

B. Chronic leukemia

123 / 210

Category: Hematology

123. What is the primary site for pre-T cell differentiation?

A. Liver

B. Spleen

C. Thymus

D. Bone marrow

124 / 210

Category: Hematology

124. Which disorder occurs when glutamic acid is replaced by valine at position 6 on both beta chains.?

A. Hgb E

B. Hgb SC

C. Sickle Cell Disease (Hgb SS)

D. Hgb C

125 / 210

Category: Hematology

125. Which type of anemia is associated with hypersegmented neutrophils?

A. Sideroblastic anemia

B. Megaloblastic anemia

C. Microcytic anemia

D. Thalassemia

126 / 210

Category: Hematology

126. What are the stages of erythrocyte maturation from the earliest recognizable stage?

A. Pronormoblast, normoblast, Polychromatophilic normoblast Orthochromic normoblast, Reticulocyte

B. Pronormoblast, Basophilic normoblast, Polychromatophilic normoblast normoblast, Reticulocyte

C. Pronormoblast, Basophilic normoblast, Polychromatophilic normoblast, Orthochromic normoblast, Reticulocyte

D. Rubriblast, metarubricyte, reticulocyte, Basophilic normoblast

127 / 210

Category: Hematology

127. Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia?

A. Chronic lymphocytic leukemia (CLL)

B. Hairy cell leukemia (HCL)

C. Acute lymphocytic leukemia (CLL)

D. Chronic myelogenous leukemia (CML)

128 / 210

Category: Hematology

128. What is the genetic translocation in FAB L3/Burkitt lymphoma?

A. t(15;17)

B. t(8;11)

C. t(8;14); with a rearrangement of the MYC oncogene

D. t(11;17)

129 / 210

Category: Hematology

129. Which protein regulates iron homeostasis ?

A. Hemosiderin

B. Transferrin

C. Hepcidin

D. Hemopexin

130 / 210

Category: Hematology

130. What are the two primary lymphoid tissues ?

A. Spleen and liver

B. Thymus and liver

C. Bone marrow and spleen

D. Bone marrow and thymus

131 / 210

Category: Hematology

131. Which of the following disorders is associated with left shift, toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score ?

A. Basophilic stipplings

B. Chronic myelogenous leukemia

C. Neutrophilic leukemoid reaction (NLR)

D. Acute myelogenous leukemia

132 / 210

Category: Hematology

132. Which stain is useful in the diagnosis of acute monocytic leukemia (FAB M5)?

A. Myeloperoxidase (MPO)

B. Periodic acid-Schiff (PAS)

C. Nonspecific esterase stains

D. Sudan Black

133 / 210

Category: Hematology

133. Which erythrocyte metabolic pathway generates NADPH ?

A. Embden-Meyerhof

B. Hexose monophosphate

C. Rapoport-Luebering

D. Methemoglobin reductase

134 / 210

Category: Hematology

134. What is this abnormality called?

A. Chediak Higash

B. Alder Reily Anomaly

C. Leukomoid Reaction

D. Large neutrophils

135 / 210

Category: Hematology

135. Which term describes a decrease in all blood cell lines?

A. Pancytopenia

B. Cellopenia

C. Reticulocytosis

D. Nucleopenia

136 / 210

Category: Hematology

136. Which test is used to differentiate Warm autoimmune hemolytic anemia (WAIHA) from hereditary spherocytosis?

A. MCHC may be >37 g/dL

B. Increased osmotic fragility

C. Increased Bilirubin

D. Positive direct antiglobulin test (DAT)

137 / 210

Category: Hematology

137. This abnormality is caused by mutation in LYST gene, what is this cell?

A. Gaucher Disease

B. May Hegglin Anomally

C. Alder Anomaly

D. Chediak Higashi

138 / 210

Category: Hematology

138. This rod is associated with acute promyelocytic leukemia(AML). Identify the cell?

A. Howell Jolly Bodies

B. Auer rods

C. Plasma cell

D. Reactive Lymphocytes

139 / 210

Category: Hematology

139. What is this cell?

A. Macrophages

B. Monocytes

C. Plasma cell

D. Reactive Lymphocytes

140 / 210

Category: Hematology

140. What is this cell?

A. Hgb SS Crystals

B. Hgb SC Crystals

C. Hgb C Crystals

D. Hgb E Crystals

141 / 210

Category: Hematology

141. Which cell type is predominant in acute myelogeneous leukemia?

A. lymphoblasts

B. myeloblasts

C. lymphocytes

142 / 210

Category: Hematology

142. What is this cell?

A. Elliptocytes

B. Dacrocytes

C. Red blood cells

D. Spherocytes

143 / 210

Category: Hematology

143. Calculate percent transferrin

Serum iron is 22 μg/dL

TIBC is 180 μg/dL

A. 17%

B. 25%

C. 12%

D. 15%

144 / 210

Category: Hematology

144. What is the MCHC?


Hemoglobin	11.1 g/dL
RBC	3.65 x 10^12/L
Hematocrit	32.5%

A. 32.2g/dL

B. 24.2g/dL

C. 34.2g/dL

D. 36.2g/dL

145 / 210

Category: Hematology

145. An aggressive form of cutaneous T-cell lymphoma is?

A. Sezary syndrome

B. Mycosis fungoides

C. Reed-Sternberg syndrome

D. Chronic myelogenous leukemia (CML)

146 / 210

Category: Hematology

146. Which test is used to differentiate chronic myelogenous leukemia (CML) from a neutrophilic leukemoid reaction (NLR)?

A. Periodic acid-Schiff (PAS)

B. Nonspecific esterase stains

C. Sudan Black

D. Leukocyte alkaline phosphatase (LAP)

147 / 210

Category: Hematology

147. What is the primary site of hematopoiesis in the third month of gestation?

A. Spleen

B. Marrow of long bones

C. Liver

D. Yolk sac

148 / 210

Category: Hematology

148. What are the stages of erythrocyte maturation from the earliest recognizable stage ?

A. Rubriblast, Prorubricyte, rubricyte, metarubricyte, reticulocyte

B. Rubriblast, rubricyte, prorubricyte, metarubricyte, reticulocyte

C. Rubriblast, rubricyte, metarubricyte, reticulocyte

D. Rubriblast, metarubricyte, reticulocyte

149 / 210

Category: Hematology

149. Which of the following characterizes anemia of chronic inflammation?

A. Serum iron Increased, transferrin decreased, and increased ferritin

B. Serum iron decreased, transferrin decreased, and decreased ferritin

C. Serum iron increased, Increased transferrin, and decreased ferritin

D. Serum iron decreased, ferritin increased, and decreased Total Iron Binding Capacity(TIBC)

150 / 210

Category: Hematology

150. Granulocytic cells will stain positive in which of the following stains?

A. Myeloperoxidase (MPO), Sudan black B, and Specific esterase stain

B. Myeloperoxidase (MPO), Periodic acid-Schiff (PAS), and non- specific esterase stain

C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains

151 / 210

Category: Hematology

151. Which of the following disorder is associated with left shift with toxic changes to neutrophils, increased WBC count, and high Leukocyte Alkaline Phosphatase (LAP) score?

A. Basophilic stipplings

B. Neutrophilic leukemoid reaction (NLR)

C. Chronic myelogenous leukemia

D. Acute myelogenous leukemia

152 / 210

Category: Hematology

152. Total iron binding capacity (TIBC) measures

A. Amount of transferrin

B. Amount of iron that transferrin can bind

C. Hepcidin

D. Ferritin

153 / 210

Category: Hematology

153. What is an excessive accumulation of iron in body tissues called?

A. Hematoma

B. Heme toxicity

C. Hematopenia

D. Hemochromatosis

154 / 210

Category: Hematology

154. Which malignant disorder is associated with left shift with myelocytes the predominate cell?

A. Acute myelogeneous leukemia

B. Chronic myelogenous leukemia

C. Acute promyelocytic leukemia (APL); FAB M3

D. Acute megakaryocytic leukemia (AMegL; FAB M7)

155 / 210

Category: Hematology

155. The majority of iron found in an adult is a constituent of

A. Haptoglobin

B. Myoglobin

C. Hemoglobin

D. Propyria

156 / 210

Category: Hematology

156. Antigen-dependent lymphopoiesis occurs in secondary lymphoid tissue located in

A. Liver and spleen

B. Spleen and kidney

C. Peyer's patches and spleen

D. Thymus and bone marrow

157 / 210

Category: Hematology

157. Which neutrophil abnormality is caused by MYH9 gene mutation, and characterized by the presence of Dohle-like bodies, giant platelets and thrombocytopenia?

A. Pelger Huet Anomaly

B. May-Hegglin anomaly

C. Chediak-Higashi syndrome

D. Chronic granulomatous disease (CGD)

158 / 210

Category: Hematology

158. Which of the following cell type will stain negative in Myeloperoxidase (MPO) stains?

A. Granulocytic cells

B. Auer rods stain

C. Lymphocytic cells

159 / 210

Category: Hematology

159. Defective nuclear maturation commonly results in the production of red cells that are ?

A. Normocytic

B. Hypochromic

C. Macrocytic

D. Microcytic

160 / 210

Category: Hematology

160. In what condition would an LAP score of 10 most likely be found?

A. Bacterial septicemia

B. Late pregnancy

C. Polycythemia vera

D. Chronic myelogenous leukemia

161 / 210

Category: Hematology

161. What are the three stages of hematopoiesis?

A. Meroblastic phase, hepatic phase, and medullary phase

B. Mesoblastic phase, primitive phase, and medullary phase

C. Primitive phase, definitive phase and hepatic phase

D. Mesoblastic phase, hepatic phase, and medullary phase

162 / 210

Category: Hematology

162. What is an increase in the percentage of lymphocytes called ?

A. Absolute lymphopenia

B. Relative lymphocytosis

C. Absolute lymphocytosis

D. Absolute polycythemia

163 / 210

Category: Hematology

163. A block in the protoporphyrin pathway resulting in defective hemoglobin synthesis is characteristic of which type of anemia?

A. Thalassemia

B. Porphyrias

C. Iron-deficiency anemia

D. Megaloblastic anemia

164 / 210

Category: Hematology

164. Which malignant disorder is characterized by the presence of oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia and abnormal morphology associated with all cell lines ?

A. Acute erythroleukemia

B. Acute myelomonocytic leukemia

C. Acute promyelocytic leukemia (APL)

D. Myelodysplastic Syndromes (MDSs)

165 / 210

Category: Hematology

165. Which cell transports oxygen and removes metabolic waste from the body ?

A. White blood cells

B. Platelets

C. Red blood cells

D. Plasma

166 / 210

Category: Hematology

166. What red cell morphologic abnormality have unevenly pointed projections and associated with abetalipoproteinemia

A. Spherocytes

B. Echinocytes

C. Dacrocytes

D. Acanthocytes

167 / 210

Category: Hematology

167. What is this cell?

A. Macrophages

B. Hairy Cell Leukemia

C. Plasma cell

D. Lymphocytes

168 / 210

Category: Hematology

168. What is the genetic translocation in chronic myelogenous leukemia (CML)?

A. t(15;17)

B. t(9;22)

C. t(8;14); with a rearrangement of the MYC oncogene

D. t(11;17)

169 / 210

Category: Hematology

169. Identify the cell

A. Microcytic normochromic red blood cells

B. Microcytic hypochromic red blood cells

C. Macrocytic red blood cells

D. Normochromic red blood cells

170 / 210

Category: Hematology

170. Which of the following is a lipid storage disorder caused by deficiency in sphingomyelinase, associated with foamy bone marrow appearance ?

A. Niemann-Pick disease

B. Gaucher disease

C. Alder normally

D. Chronic granulomatous disease (CGD)

171 / 210

Category: Hematology

171. Which leukemia is characterized by a proliferation of megakaryoblasts and positivity for CD41, CD42, and CD61 by flow cytometry?

A. Acute erythroleukemia; FAB M6

B. Acute myelomonocytic leukemia ;AMML; FAB M4

C. Acute promyelocytic leukemia (APL); FAB M3

D. Acute megakaryocytic leukemia (AMegL; FAB M7)

172 / 210

Category: Hematology

172. Where is erythropoietin produced ?

A. Brain

B. Spleen

C. Liver

D. Kidney

173 / 210

Category: Hematology

173. Which of the following is the most commonly used routine stain for blood smear?

A. Prussian blue

B. Wright's stain

C. Supravital stain

D. New methylene Blue

174 / 210

Category: Hematology

174. Microcytic, hypochromic red cells are most often associated with impaired

A. DNA synthesis

B. Hemoglobin synthesis

C. RNA metabolism

D. Enzyme metabolism

175 / 210

Category: Hematology

175. Which hemoglobin forms are incapable of oxygen transport ?

A. Deoxyhemoglobin and carboxyhemoglobin

B. Methemoglobin and deoxyhemoglobin

C. Oxyhemoglobin and deoxyhemoglobin

D. Carboxyhemoglobin and methemoglobin

176 / 210

Category: Hematology

176. Which of the following is an acquired membrane defect in which the red cell membrane has increased sensitivity for complement binding?

A. Pyruvate kinase (PK) deficiency

B. G6PD (glucose-6-phosphate dehydrogenase) deficiency

C. Hereditary spherocytosis

D. Paroxysmal nocturnal hemoglobinuria (PNH)

177 / 210

Category: Hematology

177. What is this cell?

A. Macrophages

B. Monocytes

C. Plasma cell

D. Reactive Lymphocytes

178 / 210

Category: Hematology

178. Which type of anemia will cause iron overload?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

179 / 210

Category: Hematology

179. What substance has a greater affinity for hemoglobin than oxygen ?

A. Carbon

B. Carbon dioxide

C. Carbonmonoxide

D. Oxide

180 / 210

Category: Hematology

180. What is the expected result of a solubility test for patients with Hgb SS disease?

A. Negative

B. Positive

181 / 210

Category: Hematology

181. An increased number of immature cell types in the peripheral blood is

A. Cell apoptosis

B. Cell degeneration

C. Right shift

D. Left shift

182 / 210

Category: Hematology

182. Which hemoglobin migrates with hemoglobins A2, C, and O on alkaline hemoglobin electropheroseis?

A. Hgb F

B. Hgb C

C. Hgb SC

D. Hgb E

183 / 210

Category: Hematology

183. Which of the following stains are used to differentiate blasts of acute myelogenous leukemias (AMLs) from acute lymphoblastic leukemia (ALLs)?

A. Myeloperoxidase (MPO) and Sudan black B

B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS)

C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains

184 / 210

Category: Hematology

184. Which stain is used for reticulocyte count?

A. Prussian blue

B. Wright's stain

C. Supravital stain

D. New methylene Blue

185 / 210

Category: Hematology

185. A cutaneous lymphoma that causes skin itching and ulcerative tumor are called?

A. Mycosis fungoides

B. Reed-Sternberg syndrome

C. Waldenstrom macroglobulinemia

186 / 210

Category: Hematology

186. Impaired DNA metabolism is characteristic of which type of anemia?

A. Thalassemia

B. Sideroblastic anemia

C. Iron-deficiency anemia

D. Megaloblastic anemia

187 / 210

Category: Hematology

187. Burkitt lymphoma is associated with which of the following virus?

A. Polio Virus

B. Rotavirus

C. Coxcakie Virus

D. Epstein Barr Virus

188 / 210

Category: Hematology

188. Which gene mutation is implicated in Essential thrombocythemia (ET)?

A. JAK2 oncogene

B. t(8;11)

C. t(8;14)

D. BCR/ABL oncogene

189 / 210

Category: Hematology

189. What is the most common enzyme deficiency in Embden Meyerhof Pathway?

A. G6PD (glucose-6-phosphate dehydrogenase) deficiency

B. Hereditary spherocytosis

C. Pyruvate kinase (PK) deficiency

D. Paroxysmal nocturnal hemoglobinuria (PNH)

190 / 210

Category: Hematology

190. What is an increase in the percentage of lymphocytes called?

A. Absolute lymphopenia

B. Absolute lymphocytosis

C. Relative lymphocytosis

D. Absolute polycythemia

191 / 210

Category: Hematology

191. Which hemolytic anemia is caused due to a deficiency of the enzyme ADAMTS 13?

A. Paroxysmal nocturnal hemoglobinuria (PNH)

B. Hemolytic uremic syndrome (HUS)

C. Microangiopathic hemolytic anemias (MAHAs)

D. Thrombotic thrombocytopenic purpura (TTP)uremic syndrome (HUS)

192 / 210

Category: Hematology

192. What is this cell?

A. Basophilic stipplings

B. Reticulocyte

C. Washed red blood cells

D. Artifact

193 / 210

Category: Hematology

193. Which of the following red blood cell precursors is the last stage to undergo mitosis?

A. Band neutrophils

B. Promyelocyte

C. Myelocyte

D. Segmented neutrophils

194 / 210

Category: Hematology

194. Basophilia is associated with ?

A. Type I hypersensitivity reactions

B. Leukemoid reaction (NLR)

C. Type I hypersensitivity reactions and chronic myelogenous leukemia

D. Chronic myelogenous leukemia

195 / 210

Category: Hematology

195. Hgb D Disease is caused by substitution of glutamic acid with.

A. Lysine

B. Valine

C. Leucine

D. Glycine

196 / 210

Category: Hematology

196. Impaired release of storage iron due to increased hepcidin levels will result in ?

A. Thalassemia

B. Sideroblastic anemia

C. Anemia of Chronic Inflammation

D. Iron-deficiency anemia

197 / 210

Category: Hematology

197. Which of the following factors will result in an immediate increase in oxygen delivery to the tissues ?

A. decreased body temperature

B. low 2,3-bisphosphoglycerate (2,3-BPG) level

C. Decreased pH

D. Decreased carbon release

198 / 210

Category: Hematology

198. Which erythrocyte metabolic pathway generates adenosine triphosphate (ATP) through glycolysis?

A. Methemoglobin reductase

B. Rapoport-Luebering

C. Hexose monophosphate

D. Embden-Meyerhof

199 / 210

Category: Hematology

199. What term describes a mature red blood cell that contains iron granules ?

A. Basophillic stippling

B. Siderocyte

C. Howell Jolly

D. Ringed sideroblast

200 / 210

Category: Hematology

200. Which of the following is the major transport protein of iron ?

A. Transferrin

B. Ferritin

C. Hemosiderin

D. Haptoglobin

201 / 210

Category: Hematology

201. What is this cell?

A. Dacrocytes

B. Reticulocyte

C. Sickle Cells

D. Elliptocytes

202 / 210

Category: Hematology

202. Thalassemias are the result of a?

A. Structural defect in the globin portion of hemoglobin

B. Quantitative defect in globin-chain synthesis

C. Qualitative defect in globin-chain structure

D. Qualitative defect in heme structure

203 / 210

Category: Hematology

203. Hemoglobin A2 consists of ?

A. Two alpha- and two beta-globin chains

B. Two alpha- and four beta-globin chains

C. Two alpha- and two delta-globin chains

D. Four alpha- and two beta-globin chains

204 / 210

Category: Hematology

204. Auer rods will stain positive in which of the following stains?

A. Myeloperoxidase (MPO) and Sudan black B

B. Myeloperoxidase (MPO) and Periodic acid-Schiff (PAS)

C. Periodic acid-Schiff (PAS) and Nonspecific esterase stains

205 / 210

Category: Hematology

205. Basophilic stippling is composed of

A. Vitamin K

B. RNA

C. Iron granules

D. DNA

206 / 210

Category: Hematology

206. Which hemoglobin migrates with with hemoglobins A2, E, and O on alkaline hemoglobin electropheroseis?

A. Hgb F

B. Hgb C

C. Hgb SC

D. Hgb E

207 / 210

Category: Hematology

207. Which of the following characterizes iron deficiency anemia?

A. Decreased serum iron, increased transferrin saturation, normal ferritin

B. Increased serum iron, decreased transferrin saturation, decreased ferritin

C. Decreased serum iron, decreased ferritin and Increased TIBC

D. Increased serum transferrin, increased ferritin, and decreased Total iron binding capacity (TIBC)

208 / 210

Category: Hematology

208. Which of the following is diagnostic of Multiple myeloma?

A. "M"-spike in the gamma-globulin region in serum electrophoresis

B. Bence Jones proteins in the urine

C. Excessive production IgM (macroglobulin)

D. production of excessive IgG (macroglobulin)

E. A ,B and D

209 / 210

Category: Hematology

209. What is the process of blood cell formation called?

A. Hemochromatosis

B. Apotosis

C. Hematopoiesis

D. Mitosis

210 / 210

Category: Hematology

210. In normocytic/normochromic anemia reticulocyte is

A. Increased

B. Decreased

C. Normal

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