Myeloproliferative and Lymphoproliferative Disorders -

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This 31 multiple choice quiz will test your knowledge of myeloproliferative and lymphoproliferative leukemias.

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Myeloproliferative and Lymphoproliferative Disorders

1 / 31

Category: Hematology

1. Which test is used to differentiate chronic myelogenous leukemia (CML) from a neutrophilic leukemoid reaction (NLR)?

A. Periodic acid-Schiff (PAS)

B. Nonspecific esterase stains

C. Sudan Black

D. Leukocyte alkaline phosphatase (LAP)

2 / 31

Category: Hematology

2. Which malignant disorder is characterized by the presence of oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia and abnormal morphology associated with all cell lines ?

A. Acute erythroleukemia

B. Acute myelomonocytic leukemia

C. Acute promyelocytic leukemia (APL)

D. Myelodysplastic Syndromes (MDSs)

3 / 31

Category: Hematology

3. Which of the following stain is used in the diagnosis of Hairy cell leukemia?

A. Periodic acid-Schiff (PAS)

B. Nonspecific esterase stains

C. Sudan Black

D. Tartrate-resistant acid phosphatase stain (TRAP)

4 / 31

Category: Hematology

4. Di Guglielmo syndrome is also classified as?

A. Acute megakaryocytic leukemia (AMegL; FAB M7)

B. Acute erythroleukemia; FAB M6

C. Acute myelomonocytic leukemia ;AMML; FAB M4

D. Acute promyelocytic leukemia (APL); FAB M3

5 / 31

Category: Hematology

5. Which of the following cell markers are seen in B cell malignancy?

A. CD19, and CD20 positive

B. CD2, and CD4 positive

C. CD2, CD19, and CD20 positive

D. CD4, CD19, and CD20 positive

6 / 31

Category: Hematology

6. What is the genetic translocation for FAB M2 (AML with maturation)?

A. t(15;17)

B. t(8;21)

C. t(8;14)

D. t(11;17)

7 / 31

Category: Hematology

7. Which gene mutation is implicated in polycythemia?

A. JAK2 oncogene

B. t(8;11)

C. BCR/ABL oncogene

D. t(11;17)

8 / 31

Category: Hematology

8. What is the genetic translocation in FAB L3/Burkitt lymphoma?

A. t(15;17)

B. t(8;11)

C. t(8;14); with a rearrangement of the MYC oncogene

D. t(11;17)

9 / 31

Category: Hematology

9. Burkitt lymphoma is associated with which of the following virus?

A. Polio Virus

B. Rotavirus

C. Coxcakie Virus

D. Epstein Barr Virus

10 / 31

Category: Hematology

10. Which gene mutation is implicated in Essential thrombocythemia (ET)?

A. JAK2 oncogene

B. t(8;11)

C. t(8;14)

D. BCR/ABL oncogene

11 / 31

Category: Hematology

11. Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

A. t(15;17); PML/RARA oncogene

B. t(8;11)

C. t(8;14)

D. t(11;17)

12 / 31

Category: Hematology

12. Chronic myeloproliferative disorders terminate in?

A. Acute leukemia

B. Chronic leukemia

13 / 31

Category: Hematology

13. Which leukemia is characterized by a proliferation of megakaryoblasts and positivity for CD41, CD42, and CD61 by flow cytometry?

A. Acute erythroleukemia; FAB M6

B. Acute myelomonocytic leukemia ;AMML; FAB M4

C. Acute promyelocytic leukemia (APL); FAB M3

D. Acute megakaryocytic leukemia (AMegL; FAB M7)

14 / 31

Category: Hematology

14. Which lymphoma has Reed-Sternberg cells?

A. Hodgkin lymphoma

B. Non-Hodgkin lymphoma

C. Acute lymphocytic leukemia (CLL)

D. Chronic myelogenous leukemia (CML)

15 / 31

Category: Hematology

15. Increased LAP score is seen in?

A. Chronic myelogenous leukemia (CML)

B. Paroxysmal nocturnal hemoglobinuria

C. Neutrophilic leukemoid reaction

16 / 31

Category: Hematology

16. In what condition would an LAP score of 10 most likely be found?

A. Bacterial septicemia

B. Late pregnancy

C. Polycythemia vera

D. Chronic myelogenous leukemia

17 / 31

Category: Hematology

17. An aggressive form of cutaneous T-cell lymphoma is?

A. Sezary syndrome

B. Mycosis fungoides

C. Reed-Sternberg syndrome

D. Chronic myelogenous leukemia (CML)

18 / 31

Category: Hematology

18. Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

A. Reed-Sternberg cells

B. Mycosis fungoides

C. Sezary syndrome

D. Smudge cells

19 / 31

Category: Hematology

19. Which chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

A. t(15;17)

B. t(8;11)

C. t(8;14)

D. t(11;17)

20 / 31

Category: Hematology

20. A cutaneous lymphoma that causes skin itching and ulcerative tumor are called?

A. Mycosis fungoides

B. Reed-Sternberg syndrome

C. Waldenstrom macroglobulinemia

21 / 31

Category: Hematology

21. Which gene mutation is associated with chronic myelogenous leukemia?

A. JAK2 oncogene

B. t(8;11)

C. t(8;14)

D. BCR/ABL oncogene

22 / 31

Category: Hematology

22. What is the genetic translocation in chronic myelogenous leukemia (CML)?

A. t(15;17)

B. t(9;22)

C. t(8;14); with a rearrangement of the MYC oncogene

D. t(11;17)

CD13, CD33 positive (myeloid) and CD14 positive (monocytes)

23 / 31

Category: Hematology

23. Which of the following cell markers is positive in acute myelomonocytic leukemia (AMML; FAB M4)?

A. CD13, CD15, and CD33

B. CD13, CD33 positive and CD14 positive

C. CD45 and CD71

24 / 31

Category: Hematology

24. In Waldenstrom macroglobulinemia which immunoglobin is increasingly produced?

A. IgM

B. IgG

C. IgA

D. IgS

25 / 31

Category: Hematology

25. Which malignant disorder is associated with left shift with myelocytes the predominate cell?

A. Acute myelogeneous leukemia

B. Chronic myelogenous leukemia

C. Acute promyelocytic leukemia (APL); FAB M3

D. Acute megakaryocytic leukemia (AMegL; FAB M7)

26 / 31

Category: Hematology

26. Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia?

A. Chronic lymphocytic leukemia (CLL)

B. Hairy cell leukemia (HCL)

C. Acute lymphocytic leukemia (CLL)

D. Chronic myelogenous leukemia (CML)

27 / 31

Category: Hematology

27. Smudge cell is seen in which of the following malignancy?

A. Chronic lymphocytic leukemia (CLL)

B. Hairy cell leukemia (HCL)

C. Acute lymphocytic leukemia (CLL)

D. Chronic myelogenous leukemia (CML)

28 / 31

Category: Hematology

28. The presence of the chromosomal abnormality t(15;17) with disseminated intravascular coagulation (DIC) is diagnostic of?

A. Acute myeloblastic leukemia without maturation (FAB type Ml)

B. Acute myeloblastic leukemia with maturation (FAB type M2)

C. Acute promyelocytic leukemia (FAB type M3)

D. Acute myelomonocytic leukemia (FAB type M4)

29 / 31

Category: Hematology

29. Which of the following is not classified as a myeloproliferative disorder?

A. Polycythemia vera

B. Essential thrombocythemia

C. Seizary Syndrome

D. Chronic myelogenous leukemia

30 / 31

Category: Hematology

30. Which of the following is diagnostic of Multiple myeloma?

A. "M"-spike in the gamma-globulin region in serum electrophoresis

B. Bence Jones proteins in the urine

C. Excessive production IgM (macroglobulin)

D. production of excessive IgG (macroglobulin)

E. A ,B and D

31 / 31

Category: Hematology

31. In what condition would an LAP score of 180 most likely be found?

A. Bacterial septicemia

B. paroxysmal nocturnal hemoglobinuria

C. Polycythemia vera

D. Polycythemia vera and Bacterial septicemia

Your score is

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Which Chromosomal defects are diagnostic for acute promyelocytic leukemia (APL)?

t(15;17)

Which of the following stain is used in the diagnosis of hairy cell leukemia?

Tartrate-resistant acid phosphatase stain (TRAP)

Smudge cell is seen in which of the following malignancy?

Chronic lymphocytic leukemia (CLL)

Which of the following malignancies results in dry tape on bone marrow aspiration and also presents with pancytopenia?

Hairy cell leukemia (HCL)

Which of the following is found in biopsies of individuals with Hodgkin lymphoma?

Reed-Sternberg cells

A cutaneous lymphoma that causes skin itching and ulcerative tumors are called

Mycosis fungoides

Which gene mutation is implicated in polycythemia?

JAK2 oncogene

Which malignant disorder is characterized by anisocytosis, oval macrocytes, poikilocytosis, teardrop cells, leukoerythroblastic anemia, and abnormal morphology associated with all cell lines?

Myelodysplastic Syndromes (MDS)

Myeloproliferative and Lymphoproliferative Disorders

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