For each blood group system you must know the antigens, antibody class, phase of reactivity in vitro tests, clinical significance, and other important unique charcteristics.
Blood group
Enzyme treatment
Immunoglobulin type
Disease Association
Kell
Antigens: K (Kell), k (Cellano), Kpa, Kpb, Jsa, Jsb
No effect
IgG
McLeod phenotype
Duffy
Fya and Fyb
Dosage effect
Destroys Fya and Fyb
IgG
HTR and HDN
Fy (a-b-) phenotype: resistant to malarial infection caused by Plasmodium vivax